Treatment of advanced neuroendocrine tumours with the radiolabelled somatostatin analogue octreotide

Gregory A. Kaltsas, Zoe Stefanidou, Dimitris Papadogias, Ashley B. Grossman

Neuroendocrine tumours (NET) have a particular tendency to express functional receptors and/or uptake mechanisms. Radionuclides, such as 111In-pentetreotide, a somatostatin analogue, which bind to somatostatin receptors, present an imaging modality that has been used for both the diagnosis and staging of NET…

Structure-function relationships of glycoprotein hormones; lessons from mutations and polymorphisms of the thyrotrophin and gonadotrophin subunit genes

Maria Alevizaki1, Ilpo Huhtaniemi2 1Endocrine Unit, Department of Medical Therapeutics, Athens University School of Medicine, Athens, Greece, and 2Institute of Reproductive and Developmental Biology, Imperial College Medical Faculty, London, U.K. Abstract The pituitary glycoprotein hormones thyrotrophin (thyroid-stimulating hormone, TSH), lutrophin (luteinising hormone, LH) and follitrophin (follicle-stimulating hormone, FSH), as well as the placental choriongonadotrophin (human Read More

Dyslipidemia in patients with thyroid disorders

Evagelos N Liberopoulos, Moses S Elisaf Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece Abstract Thyroid disorders are known to influence lipid metabolism and are common in dyslipidemic patients. Overt and subclinical hypothyroidism have an adverse effect on the serum lipid profile that may predispose to the development of atherosclerotic disease. Although Read More

Leptin, nutrition and reproduction: new insights

Vera Popovic1, Felipe F. Casanueva2 1Institute of Endocrinology,Diabetes and Metabolic Diseases, University Clinical Center, Belgrade, Serbia and 2Department of Medicine, Endocrinology Section, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain Abstract Recent data suggest that in addition to leptin’s role in conveying signals of the amount of energy stores to the central nervous system, Read More

Pitutaty insufficiency. Diagnosis masked by a toxic thyroid adenoma

Maria Alevizaki1,2, Lia-Angela Moulopoulos3, Emily Mantzos1, Demetrios A. Koutras1,2 Endocrine Units, “Evgenidion” Hospital1, Department of Clinical Therapeutics2, ALEXANDRA Hospital, and 3Dept of Roentgenology, Athens University School of Medicine, 11528 Athens, Greece Abstract A patient with undiagnosed pituitary insufficiency who also had a toxic thyroid adenoma is presented. The T3 secreted by the adenoma apparently corrected Read More

β-thalassemia and gonadal axis: a cross-sectional, clinical study in a Greek population

John Papadimas, Dimitrios G. Goulis, Eudokia Mandala, George Georgiadis, Vassiliki Zournatzi, Basil C. Tarlatzis, John N. Bontis Unit of Reproductive Endocrinology, 1st Department of Obstetrics & Gynecology, Hippocration General Hospital, Aristotle University of Thessaloniki, 546 42 Thessaloniki, Greece Abstract β-thalassemia (β-thal) is characterized by disturbances of the reproductive system. The aim of the present study Read More

Differentiated thyroid cancer in Greece: 1963-2000. Relation to demographic and environmental factors

Ioannis Ilias1, Maria Alevizaki1, Elli Lakka-Papadodima2, Demetrios A. Koutras1 1Department of Clinical Therapeutics, “Alexandra” Hospital & Endocrine Unit, “Evgenidion” Hospital, Athens University School of Medicine, 2Endocrine Clinic, “Athens Polyclinic” Hospital, Athens, Greece Abstract Thyroid cancer (TC) is a relatively rare neoplasia, accounting for 0.35%-0.38% of total deaths due to cancer in Greece. Environmental/nutritional factors are Read More

Compensatory adrenal growth in relation to stress of surgery and estradiol in adult male rats

Nicholas Bikas, Joan Gribisi, Joan Messari and Anastasia Sfikakis

ACTH infusion at the time of unilateral adrenalectomy inhibits the early rapid compensatory growth (CAG) in the remaining adrenal. We examined the hypothesis that different duration of surgery and/or the enhanced response to the stress of surgery, induced by estradiol treatment, might modify CAG. Adult male rats untreated …

Endemic Goiter – an update

Demetrios A. Koutras

“Goiter” means thyroid enlargement, and “endemic” means frequent in a certain locality. The problem is from what volume and up a thyroid is considered to be large enough as to be classified as goiter and also from what prevalence and up an area is considered to be endemic. It is obvious that by playing with these definitions one may increase or decrease …