Genetics and Hormones in Testicular Descent*

Marko Kaleva and Jorma Toppari

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Testicular descent is an essential part of normal male sexual development. Any anomaly that disrupts normal testicular descent will be clinically evident as cryptorchidism. Several factors, such as Hoxa-10, epidermal growth factor (EGF), calcitonin gene-related peptide (CGRP), and hormones, especially androgens and insulin-like factor 3

Steroid hormones interrelationships in the metabolic syndrome: An introduction to the ponderostat hypothesis

Marià Alemany

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The clairvoyant early implication of sex hormones in the characterization of the metabolic syndrome (MS) was detected early, and in accordance with the well-known sex-related main patterns of fat deposition in obesity: gynoid and android …

The endocrinology of baldness

Menelaos L. Batrinos

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Male pattern baldness, scientifically known as androgenetic alopecia (AGA), is a very common condition, universally prevalent, which progresses with aging. The loss of scalp hair of any degree both in men and women is a cause of considerable psychological distress …

Strong and positive association of Endothelin-1 with AGEs in PCOS: A causal relationship or a bystander?

Christakou Charikleia, Economou Frangiskos, Livadas Sarantis, Piperi Christina, Adamopoulos Christos, Marinakis Evangelos, Diamanti-Kandarakis Evanthia

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OBJECTIVE: Advanced glycation end products (AGEs) activate the intracellular Nuclear Factor-κB pathway in endothelial cells, leading to production of endothelin-1 (ET-1), a peptide which causes endothelial dysfunction. The aim of the present study was to assess ΕΤ-1 and AGEs levels in women with polycystic ovary syndrome …

Associations of menstrual cycle irregularities with age, obesity and phenotype in patients with polycystic ovary syndrome

Dimitrios Panidis, Konstantinos Tziomalos, Efstathios Papadakis, Panagiotis Chatzis, Eleni A. Kandaraki, Elena A. Tsourdi, Djuro Macut, Jelica Bjekic-Macut, Apostolos Marthopoulos, Ilias Katsikis

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OBJECTIVE: Limited data suggest that menstrual cycle abnormalities are more pronounced in younger and more obese patients with polycystic ovary syndrome (PCOS). We aimed to evaluate the association between menstrual cycle pattern and age, obesity and PCOS phenotype in a large population of women with PCOS …