The “homeostasis hormone” and its CRF1 receptor. From structure to function

Hesham Fahmy, Katerina Spyridaki, Bhimanna Kuppast, George Liapakis

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The maintenance of homeostasis is a basic prerequisite for life, ensuring the stability of our body in response to external or internal stimuli (stressful stimuli). The maintenance of homeostasis requires alterations in the function of the endocrine system …

Corticotropin-releasing factor (CRF) system localization in human fetal heart

Efterpi Chouridou, Maria Lambropoulou, Maria Koureta, Christina Zarouchlioti, Ioanna Balgouranidou, Evangelia Nena, Nikolaos Papadopoulos, Ekaterini Chatzaki

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OBJECTIVE: The corticotropin-releasing factor (CRF) family consists of the neuropeptides CRF, Ucn I, II and III and the binding sites CRFR1, CRFR2 and CRF-BP. It regulates stress response and the homeostasis of an organism. In this study, we examined the presence of the CRF system in the human hearts of normal and pathological fetuses. DESIGN: Heart tissues from 40 archival human fetuses were divided …