The role of iodine in the evolution of thyroid disease in Greece: from endemic goiter to thyroid autoimmunity

Stelios Fountoulakis, George Philippou, Agathocles Tsatsoulis

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The thyroid gland is dependent on dietary iodine for the production of thyroid hormones, normal iodine requirement being about 150-200μg/day. Long-term deficiency in iodine intake is associated with the development of goiter. When the prevalence of goiter in a population rises above 5-10%, the problem is considered endemic …

Autoimmunity in differentiated thyroid cancer: Significance and related clinical problems

Ulla Feldt-Rasmussen, Åse Krogh Rasmussen

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Coexistence of differentiated thyroid cancer (DTC) and thyroid autoimmune diseases could represent a mere coincidence due to the frequent occurrence of autoimmunity, but there may also be a pathological and causative link between the two conditions. The coincidence of DTC with Hashimoto’s disease has been variably reported …

Epidemiological characteristics of children with autoimmune thyroid disease

Vasiliki Skarpa, Eleni Κousta, Athanasia Tertipi, Konstantinos Anyfandakis, Marina Vakaki, Maria Dolianiti, Aspasia Fotinou, Asteroula Papathanasiou

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OBSECTIVE: Chronic autoimmune thyroiditis (AT) is the most common cause of thyroid disease in children. The aim of the study was to define the epidemiological clinical and laboratory characteristics of children and adolescents with AT. DESIGN: Various parameters including thyroid ultrasonography of 228 children and adolescents …

Thyroid diseases during pregnancy: A number of important issues

Gerasimos Krassas, Spyridon N. Karras, Nikolaos Pontikides

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The most common thyroid diseases during pregnancy are hyper- and hypothyroidism and their variants including isolated hypothyroxinemia (hypo-T4), autoimmune thyroid disease (AITD) and different types of goiter. AITD represents the main cause of hypothyroidism during pregnancy ranging in prevalence between 5 and 20% …

Autoimmune thyroiditis in children and adolescents with type 1 diabetes mellitus is associated with elevated IgG4 but not with low vitamin D

Korcan Demir, Mehmet Keskin, Yιlmaz Kör, Murat Karaoğlan, Özlem Gümüştekin Bülbül

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OBJECTIVE: To assess levels of vitamin D and of immunoglobulin G subclasses in children and adolescents with type 1 Diabetes Mellitus with or without autoimmune thyroiditis. DESIGN: Among 213 patients with type 1 diabetes, the cases with thyroid-specific autoantibodies …

Relationship between serum zinc levels, thyroid hormones and thyroid volume following successful iodine supplementation

Sibel Ertek, Arrigo FG Cicero, Oya Caglar, Gurbuz Erdogan

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OBJECTIVE: Zinc is essential for many biochemical processes and also for cell proliferation. Thyroid hormones influence zinc metabolism by affecting zinc absorption and excretion. Additionally, zinc deficiency affects thyroid function. The aim of the present study was to evaluate a possible association of zinc levels with thyroid volume …

Severe hypothyroidism due to autoimmune thyroiditis in a child: a one-year follow-up

Francesco Vierucci, Graziano Cesaretti

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Autoimmune thyroiditis is considered to be the most common autoimmune condition, with a female preponderance of 2:1. While its overall prevalence peaks in adulthood, autoimmune thyroiditis may affect children and adolescents, particularly during early to mid-puberty …