Comments on gestational diabetes mellitus: from pathophysiology to clinical practice

Pavlos Poulakos, Gesthimani Mintziori, Efrosini Tsirou, Eleftheria Taousani, Dimitra Savvaki, Vikentia Harizopoulou, Dimitrios G. Goulis

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Gestational diabetes mellitus (GDM) is a topic of major interest, as it affects up to 16% of pregnant women and may lead to adverse pregnancy outcomes, which, however, are preventable by appropriate treatment. The aim of the present study was to discuss basic concepts and to critically appraise recent updates on practical issues …

Thyroid Nodules 2006: Managing what has been known for over 50 years

Jeffrey R. Garber

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The 50th anniversary of the publication of Mortensen, Woolner and Bennet’s paper entitled Gross and microscopic findings in clinically normal thyroid glands has just passed. 1 Their paper reported that at autopsy at the Mayo Clinic approximately half of those not known to have thyroid disease pre-mor­tem had thyroid nodules …

Ectopic thyroid: etiology, pathology and management

Nasiru Akamnu Ibrahim, Idowu Olusegun Fadeyibi

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Ectopic thyroid refers to the presence of thyroid tissue in locations other than the normal anterior neck region between the second and fourth tracheal cartilages. It is the most frequent form of thyroid dysgenesis, accounting for 48-61% of the cases.1 Prevalence of this condition is reported to be between 1 per 100,000-300,000 persons …

Subclinical Cushing’s syndrome: Current concepts and trends

George N. Zografos, Iraklis Perysinakis, Evangeline Vassilatou

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Clinically inapparent adrenal masses which are incidentally detected have become a common problem in everyday practice. Approximately 5-20% of adrenal incidentalomas present subclinical cortisol hypersecretion which is characterized by subtle alterations of the hypothalamic-pituitary-adrenal …

More on the management of lateral neck ectopic thyroid tissue

Rafael Denadai, Luίs Ricardo Martinhão Souto

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We read with interest the review article by Ibrahim and Fadeyibi and have the following comments regarding the evaluation of lesions in ectopic thyroid. Although the authors point out that fine needle aspiration cytology (FNAC) is important when malignancy is suspected …

Central precocious puberty due to hypothalamic hamartoma in neurofibromatosis type 1

Emanuele Bartolini, Stefano Stagi, Perla Scalini, Andrea Bianchi, Antonio Ciccarone, Mario Mascalchi

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In neurofibromatosis type 1 (NF1), Central Precocious Puberty (CPP) occurs almost invariably in association with optic pathway tumors, usually pilocytic astrocytoma. However, at times the aetiology remains. On the other hand, in the general population CPP develops due to an underlying hypothalamic hamartoma in up to 10% of patients. To the best of our knowledge, CPP due to hypothalamic hamartomas in NF1 has been reported only once in the literature …