Tag: Diagnosis

Thyroid Nodules 2006: Managing what has been known for over 50 years

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Jeffrey R. Garber

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The 50th anniversary of the publication of Mortensen, Woolner and Bennet’s paper entitled Gross and microscopic findings in clinically normal thyroid glands has just passed. 1 Their paper reported that at autopsy at the Mayo Clinic approximately half of those not known to have thyroid disease pre-mor­tem had thyroid nodules …

Central precocious puberty due to hypothalamic hamartoma in neurofibromatosis type 1

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Emanuele Bartolini, Stefano Stagi, Perla Scalini, Andrea Bianchi, Antonio Ciccarone, Mario Mascalchi

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In neurofibromatosis type 1 (NF1), Central Precocious Puberty (CPP) occurs almost invariably in association with optic pathway tumors, usually pilocytic astrocytoma. However, at times the aetiology remains. On the other hand, in the general population CPP develops due to an underlying hypothalamic hamartoma in up to 10% of patients. To the best of our knowledge, CPP due to hypothalamic hamartomas in NF1 has been reported only once in the literature …