Stress neuropeptides in the human endometrium: Paracrine effects on cell differentiation and apoptosis

Achille Gravanis, Antonis Makrigiannakis, Ekaterini Chatzaki, Emmanuel Zoumakis, Christos Tsatsanis, Andrew N. Margioris

Human endometrium exhibits characteristics of a neuroendocrine-like stress organ in addition to its classical role as the main target of ovarian steroid hormones. Indeed, the epithelial cells of human endometrium express the stress-associated neuropeptide genes corticotropin-releasing hormone (CRH), proopiomelanocortin, proenkephalin and prodynorphin…

Continuous combined replacement therapy in postmenopausal women: effect on plasma lipoproteins, bone mass and the endometrium

Odysseas Gregoriou,George Christodoulakos, Charalambos Siristatidis, Socrates Conidaris, Evangelia Kouskouni, George Creatsas

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Objective: The purpose of this study was to examine the effects of Hormone Replacement Therapy (HRT) on plasma lipoprotein levels, bone mass and the endometrium. Methods: Thirty healthy women were enrolled in the study for climacteric symptoms and received a combination of 17β-estradiol and norethisterone acetate continuously for 2 years …