Edward M. Brown
The system that regulates extracellular calcium (Ca2+o) homeostasis maintains a nearly constant level of Ca2+o so as to ensure the availability of calcium for its numerous intra- and extracellular roles. The molecular cloning and characterization of a G protein-coupled, Ca2+o-sensing receptor has elucidated the mechanism through which parathyroid cells …
Salvatore Maria Corsello, Rosa Maria Paragliola, Pietro Locantore, Francesca Ingraudo, Maria Pia Ricciato, Carlo Antonio Rota, Paola Senes, Alfredo Pontecorvi
Zoledronic acid is a newly FDA-approved bisphosphonate for the treatment of hypercalcemia of malignancy. Although the safety and efficacy of this drug in treating hypercalcemia associated with hyperparathyroidism have not yet been established in clinically controlled trials, its off-label use is not uncommon …