Structure-function relationships of glycoprotein hormones; lessons from mutations and polymorphisms of the thyrotrophin and gonadotrophin subunit genes

Maria Alevizaki, Ilpo Huhtaniemi

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The pituitary glycoprotein hormones thyrotrophin (thyroid-stimulating hormone, TSH), lutrophin (luteinising hormone, LH) and follitrophin (follicle-stimulating hormone, FSH), as well as the placental choriongonadotrophin (human chorionic gonadotrophin, hCG) are composed of a common α-subunit and a specific β-subunit, coupled by noncovalent interactions …

A case of Dyke-Davidoff-Masson syndrome associated with central hypothyroidism and secondary adrenal insufficiency

Jong Wook Kim, Eun Sook Kim, Woojun Kim, Young Do Kim, Eun Young Mo, Sung Dae Moon, Je Ho Han

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A diagnosis of central hypothyroidism (CH) can be missed easily or delayed without a high index of suspicion due to normal or slightly altered thyroid stimulating hormone (TSH) levels during the initial screening test for thyroid dysfunction …

Isolated idiopathic central hypothyroidism in an adult, possibly caused by Thyrotropin Releasing Hormone (TRH) deficiency

Alma Prieto-Tenreiro, Patricia Diaz-Guardiola

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Central Hypothyroidism (Central H) is mainly due to acquired lesions, either in the pituitary, the hypothalamus or both, and in such cases it is usually associated with deficient secretion of other pituitary hormones. Isolated central hypothyroidism (I Central H) remains a very rare disease. By the use of the serum Thyroid Stimulating Hormone …