Testicular leydig cell tumor presenting as primary infertility

Athina Markou, Justin Vale, Bhumita Vadgama, Marjori Walker, Stephen Franks

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A 29-year old male and his wife presented with an 18 month history of primary infertility. History and initial investigations suggested no major female pathologic component but a semen analysis revealed azoospermia. There was no history of any sexual dysfunction and neither partner was receiving any medication …

Homeostasis. The Ancient Greek Origin of a Modern Scientific Principle

Theano D. Kontopoulou, Spyros G. Marketos

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Many medical terms have a long history. They are first introduced as a concept and later acquire their proper name. In this article we trace the origin of the term homeostasis, which in modern medicine means the complex balance and the constancy of all aspects of body function and the coordinated regulation of its component fluids and cells…

Pituitary insufficiency. Diagnosis masked by a toxic thyroid adenoma

Maria Alevizaki, Lia-Angela Moulopoulos, Emily Mantzos, Demetrios A. Koutras

A patient with undiagnosed pituitary insufficiency who also had a toxic thyroid adenoma is presented. The T3 secreted by the adenoma apparently corrected the secondary thyroid failure, but also aggravated the secondary adrenal failure and almost precipitated adrenal crisis. The diagnostic work-up in such an unusual co-existence is discussed…

Endocrine terminology in Corpus Hippocraticum “In memory of Professor D.G. Ikkos”

Effie Poulakou-Rebelakou, Spyros G. Marketos

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Many Greek and Latin medical terms are in use on account of the fact that modern day Western conventional medicine originates in Greek and Roman anti-quity. The writings of Hippocrates and Galen, as well as of Celsus and Plinius…

Primary malignant fibrous histiocytoma on the thyroid

Fotini Malandrinou, Sofia Tseleni-Balafouta, Nicolaos Kakaviatos, Panagiotis Singhellakis

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A 42-year old white female with a primary Malignant Fibrous Histiocytoma (MFH) is described. The patient was examined for a “cold” nodule of the thyroid diagnosed five years previously. The patient had been on L-thyroxine therapy for three years which was discontinued by the patient 18 months prior to the present visit …

Pycnodysostosis: Toulouse-Lautrec’s and Aesop’s disease?

Christos S. Bartsocas

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Among the several causes of short stature is pycnodysostosis, also known as “Toulouse-Lautrec’s disease”. Robert Weismann-Netter is credited with the first description of the disorder which later became known as pycnodysostosis. Only a few, however, know that pycnodysostosis was also possibly Aesop’s disease …