β-thalassemia and gonadal axis: a cross-sectional, clinical study in a Greek population

John Papadimas, Dimitrios G. Goulis, Eudokia Mandala, George Georgiadis, Vassiliki Zournatzi, Basil C. Tarlatzis, John N. Bontis

β-thalassemia (β-thal) is characterized by disturbances of the reproductive system. The aim of the present study was: 1) to assess the hypothalamic _ pituitary – gonadal axis in patients with β-thal in relation to their phenotype and 2) to determine prognostic features of current gonadal status. We studied 135 patients (67 males and 68 females) with β-thal through history…

Pubertal arrest due to Zn deficiency The effect of zinc supplementation

Zuleyha Karaca, Fatih Tanriverdi, Selim Kurtoglu, Serife Tokalioglu, Kursad Unluhizarci, Fahrettin Kelestimur

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The Prasad S yndrome is characterized by iron deficiency anemia, hepatosplenomegaly, skin changes, hypogonadism, dwarfism and geophagia. Hypogonadism is a major manifestation of zinc (Zn) deficiency in both humans and animals. T he mechanism of hypogonadism caused by Zn deficiency has not been clarified…