Sodium Iodide Symporter (NIS) and Thyroid

Christine Spitzweg, John C. Morris

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Active transport of iodide into the thyroid gland is a crucial and rate-limiting step in the biosynthesis of thyroid hormones which play an important role in the metabolism, growth and maturation of a variety of organ systems, in particular the nervous system1. Although, iodide transport into the thyroid gland has been known …

Glucocortidoid sensitivity assessed in peripheral blood cells do not correlate with the feedback sensitivity of the hypothalamo-pituitary adrenal AXIS

Dimitra Vasiliadi, Yannis Gratsias, Stylianos Tsagarakis, Eythimia Botoula, Panagiotis Trivizas, Nick Thalassinos, Paraskevi Moutsatsou

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Glucocorticoids (GC) affect virtually all organ systems, acting mainly via the glucocorticoid receptor (GR). The immune system is the best characterized tissue for assessing GC sensitivity. It is well established that the immune system GC sensitivity varies widely between normal subjects …

Ketogenic diet and testosterone increase: Is the increased cholesterol intake responsible? To what extent and under what circumstances can there be benefits?

Heitor Oliveira Santos

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The new study by Jacob Wilson et al. demonstrated that a nutritional intervention based on the ketogenic diet (KD) in resistance-trained athletes of college age showed an increase of total testosterone compared to individuals who followed a Western diet (WD) protocol with the same resistance training. The total testosterone increase in the KD group …

Pycnodysostosis: Toulouse-Lautrec’s and Aesop’s disease?

Christos S. Bartsocas

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Among the several causes of short stature is pycnodysostosis, also known as “Toulouse-Lautrec’s disease”. Robert Weismann-Netter is credited with the first description of the disorder which later became known as pycnodysostosis. Only a few, however, know that pycnodysostosis was also possibly Aesop’s disease …

European Thyroid Association guidelines in comparison with the American Thyroid Association and Endocrine Society practice guidelines for the screening and treatment of hypothyroidism during pregnancy

Gesthimani Mintziori, Dimitrios G. Goulis

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It is with great interest that we read the detailed and well enunciated comparison between the American Thyroid Association (ATA) and the Endocrine Society (ES) practice guidelines for the screening and treatment of hypothyroidism during pregnancy that was published in the last issue of Hormones …