Compensatory adrenal growth in relation to stress of surgery and estradiol in adult male rats

Nicholas Bikas, Joan Gribisi, Joan Messari and Anastasia Sfikakis

ACTH infusion at the time of unilateral adrenalectomy inhibits the early rapid compensatory growth (CAG) in the remaining adrenal. We examined the hypothesis that different duration of surgery and/or the enhanced response to the stress of surgery, induced by estradiol treatment, might modify CAG. Adult male rats untreated …

Pituitary-adrenal responses following major abdominal surgery

Ioanna Dimopoulou, Marinella Tzanela, Dimitra Vassiliadi, Irini Mavrou, Petros Kopterides, Stylianos Orfanos, Anastasia Kotanidou, Styliani Kontogiannopoulou, Spyridon Vasdekis, Iraklis Tsangaris, Apostolos Armaganidis, Anastasios Macheras, Ioannis Ilias, Georgia Kostopanagiotou, Stylianos Tsagarakis

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OBJECTIVE: Perioperative pituitary-adrenal responses after major abdominal surgery have not been well characterized. The aim of the present study was to further clarify perioperative pituitary-adrenal responses. DESIGN: Thirty-six patients (20 men), aged 68±10 years (mean±SD), undergoing major abdominal operations were studied …

Laparoscopic vs. open abdominal surgery in male pigs: Marked differences in cortisol and catecholamine response depending on the size of surgical incision

Angeliki Krikri, Vasileios Alexopoulos, Emmanouil Zoumakis, Paraskevas Katsaronis, Evangelos Balafas, Gregory Kouraklis, Panagiotis E. Karayannacos, George P. Chrousos, Gregory Skalkeas

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OBJECTIVE: Minimally invasive operations, such as laparoscopic cholecystectomy and adrenalectomy, result in a more rapid recovery of normal function, less physiological disturbances and less stress to the organism than similar open operations. The purpose of this study was to determine the stress response associated …