Journal Articles
High density lipoprotein is positively correlated with the changes in circulating total adiponectin and high molecular weight adiponectin during dietary and fenofibrate treatment
Georgios A. Christou, Constantinos C. Tellis, Moses S. Elisaf, Alexandros D. Tselepis, Dimitrios N. Kiortsis
OBJECTIVE: The investigation of the relationship between high density lipoprotein (HDL) and adiponectin. DESIGN: Thirty-seven obese or overweight [body mass index ≥27 Kg/m2], hypertriglyceridemic patients underwent one of the following interventions for 3 months …
Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values
Marianna Katrinaki, Marilena Kampa, Andrew Margioris, Elias Castanas, Niki Malliaraki
OBJECTIVE: The determination of the normal range of 25-hydroxyvitamin D [25-(OH)D], though currently based on suppression of PTH levels, still remains a controversial issue. The 25-(OH)D levels exhibit gender and seasonal variability, the latter attributed in part to changes of insolation. DESIGN: The aim of this cross-sectional study was to estimate the levels of 25-(OH)D on the island of Crete …
Chronic autoimmune thyroid disease in children and adolescents in the years 1999-2004 in Lower Silesia, Poland
Teresa Zak, Anna Noczýnska, Renata Wasikowa, Urszula Zaleska-Dorobisz, Anna Golenko
The aim of the study was to analyze data related to chronic autoimmune thyroid disease at diagnosis and at follow-up of children and adolescents in Lower Silesia in the years 1999-2004. Age, gender, incidence of thyroid disease in the family, clinical presentation, hormonal findings, levels of thyroid antibodies, results of ultrasonography, and fine needle aspiration biopsy (FNAB) were recorded …
Stimulation of the hypothalamic-pituitary-adrenal axis with corticotropin releasing hormone in patients with psoriasis
Evangelos Karanikas, Faidon Harsoulis, Ioannis Giouzepas, Ioannis Griveas
OBJECTIVE: Psychocutaneous diseases constitute a large proportion of psychosomatic disorders, with psoriasis being one of the most typical cases. Though alteration of Hypothalamic-Pituitary-Adrenal (HPA) axis function has been suggested as underlying several psychiatric disorders and psychosomatic diseases, there is little evidence of reduced response of the HPA axis in psoriasis after psychosocially …
Muscle strength and bone in healthy women: effect of age and gonadal status
Cristiana Cipriani, Elisabetta Romagnoli, Vincenzo Carnevale, Ida Raso, Addolorata Scarpiello, Maurizio Angelozzi, Andrea Tancredi, Stefania Russo, Federica De Lucia, Jessica Pepe, Salvatore Minisola
OBJECTIVE: The aim of this work was to examine the effects of age and menopause on muscle strength and on the muscle-bone interaction. DESIGN: One hundred ninety-four healthy women (mean age 49.8 ± 12.6 SD years) were assessed …
Low vitamin D status is associated with hypothyroid Hashimoto’s thyroiditis
Dohee Kim
OBJECTIVE: The association of low vitamin D status with autoimmune thyroid disease (AITD), which includes Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), is controversial. The aim of this study was to investigate the correlation between vitamin D insufficiency and AITD, HT, and GD. DESIGN: Our cross-sectional study included patients …
R831X mutation of the androgen receptor gene in an adolescent with Complete Androgen Insensitivity Syndrome and bilateral testicular hamartomata
Dimitrios G. Goulis, Paschalia K. Iliadou, Athanasios Papanicolaou, Ioannis Georgiou, Anthi Chatzikyriakidou, Spiridon Gerou, Ioannis N. Bontis, Ioannis Papadimas
An 18-year old, phenotypically female individual was examined for primary amenorrhea. Three months before her referral, the patient underwent surgery and a pelvic mass was removed. The physical examination revealed normal female external genitalia, normal breast development, sparse pubic hair and absence of axillary hair…
IGF-I generation test in prepubertal children with Noonan syndrome due to mutations in the PTPN11 gene
Silvano Bertelloni, Giampiero I. Baroncelli, Eleonora Dati, Silvia Ghione, Fulvia Baldinotti, Benedetta Toschi, Paolo Simi
BACKGROUND: Short stature represents one of the main features of children with Noonan syndrome. The reason for impaired growth remains largely unknown. OBJECTIVE: To assess GH and IGF1 secretion in children with Noonan syndrome …
Factors influencing the outcome of microsurgical transsphenoidal surgery for pituitary adenomas: A study on 184 patients
Kostas I. Lampropoulos, George Samonis, Panagiotis Nomikos
OBJECTIVE: Evaluation of factors influencing the outcome of microsurgical transsphenoidal surgery in patients harbouring pituitary adenomas as well as of the efficacy and safety of this procedure. DESIGN: A total of 184 consecutive patients with pituitary adenomas …
Clinical utility of FDG-PET for diagnosis of adrenal mass: a large single-center experience
Allison Pitts, Grace Ih, Meng Wei, Deepti Dhall, Nicholas N. Nissen, Alan Waxman, Run Yu
OBJECTIVE: To examine the clinical utility of 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) for diagnosing whether an adrenal mass is malignant, in contemporary clinical practice. DESIGN: Retrospective medical record review of patients from 2 databases at a large hospital …
A novel mutation of the calcium-sensing receptor gene in a German subject with familial hypocalciuric hypercalcemia and primary hyperparathyroidism
Marios Papadakis, Natalie Meurer, Theodora Margariti, Anke Meyer, Norbert Weyerbrock, Cornelia Dotzenrath
OBJECTIVE: The coexistence of familial hypocalciuric hypercalcemia (FHH) and primary hyperparathyroidism (PHPT) is extremely rare. Genetic evidence has demonstrated a causal relationship between FHH and the presence of inactivating mutations in the calcium-sensing receptor gene …
A SOX3 (Xq26.3-27.3) duplication in a boy with growth hormone deficiency, ocular dyspraxia, and intellectual disability: A long-term follow-up and literature review
Stefano Stagi, Elisabetta Lapi, Marilena Pantaleo, Giovanna Traficante, Sabrina Giglio, Salvatore Seminara, Maurizio de Martino
OBJECTIVE:SOX3 is located on the long arm of the X chromosome (Xq27.1) and both the under- and over-expression of this gene have been reported in cases of hypopituitarism with or without intellectual disabilities. Nevertheless, only a few cases have as yet been extensively described …
Effect of hyperglycemia and hyperinsulinemia on glutathione peroxidase activity in non-obese women with polycystic ovary syndrome
Ana Savic-Radojevic, Ivana Bozic Antic, Vesna Coric, Jelica Bjekic-Macut, Tanja Radic, Milos Zarkovic, Tatjana Djukic, Marija Pljesa-Ercegovac, Dimitrios Panidis, Ilias Katsikis, Tatjana Simic, Djuro Macut
OBJECTIVE: In order to gain deeper insight into molecular mechanisms underlying oxidative stress (OS) and its relation to insulin resistance and hyperandrogenemia, plasma markers of OS and antioxidant glutathione-peroxidase (GPX) activity were studied in non-obese polycystic ovary syndrome (PCOS) women via the oral glucose tolerance test …
Gonadotropin releasing hormone analog treatment in children with congenital adrenal hyperplasia complicated by central precocious puberty
Ayla Güven, Ayşe Nurcan Cebeci, Suna Hancili
OBJECTIVE: Congenital adrenal hyperplasia (CAH) can be complicated by central precocious puberty (CPP) in children, which may compromise final height. We aimed to evaluate the effect of gonadotropin-releasing hormone analog (GnRHa) therapy on growth in children with CAH …
Impact of cancer and cancer treatment on male fertility
Ioannis Vakalopoulos, Petros Dimou, Ioannis Anagnostou, Theodosia Zeginiadou
While cancer, and especially testicular cancer and Hodgkin’s disease, affects male fertility in many ways, the current increase of survival of male cancer patients of reproductive age or earlier has emerged as a new challenge to their subsequent ability to father children. Cancer treatments, including surgery, radiotherapy and chemotherapy …
Validity and reliability of the Greek version of the Diabetic Foot Ulcer Scale – Short Form (DFS-SF)
Nick Kontodimopoulos, Anastasia Veniou, Nicholas Tentolouris, Dimitris Niakas
OBJECTIVE: Diabetic foot ulcer is a critical and costly complication of diabetes mellitus. The aim of this study was to assess the psychometric properties of the Greek version of the diabetic foot ulcer scale – short form (DFS-SF). DESIGN: A sample of patients with diabetic foot ulcer (N=110) was surveyed with the DFS-SF …
Clinical Case Seminar. Peculiar prolactinomas in patients with pituitary developmental gene mutations: from an adult endocrinologist perspective
Mirjana Doknic, Sandra Pekic, Milorad Civcic, Vera Popovic
CONTEXT: Congenital hypopituitarism is a syndrome which is associated with single or multiple pituitary hormone deficiencies. Mutations in a number of developmental genes have been linked to combined pituitary hormone deficiencies, the most common being mutation in the pituitary …
Type 2 diabetes mellitus is associated with obesity, smoking and low socioeconomic status in large and representative samples of rural, urban, and suburban adult Greek populations
Nicholas Tentolouris, Alexandros Andrianakos, Georgios Karanikolas, Dimitrios Karamitsos, Panagiotis Trontzas, Petros Krachtis, Fotis Christoyannis, Elpiniki Tavaniotou, Zouboulio Nikolia, Evaggelia Kaskani, Leonidas Kontelis, Petros P. Sfikakis
OBJECTIVE: In this cross-sectional epidemiologic study we examined the association between type 2 diabetes mellitus and demographic, clinical, and socioeconomic parameters in large rural, urban and suburban populations of adult Greeks. DESIGN: Of the total target adult population …
Increased prevalence of growth hormone deficiency in patients with vernal keratoconjuntivitis; An interesting new association
Stefano Stagi, Neri Pucci, Laura di Grande, Cinzia de Libero, Roberto Caputo, Stefano Pantano, Salvatore Seminara, Maurizio de Martino, Elio Novembre
INTRODUCTION: Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis that mainly affects children living in temperate areas. The notable difference between genders and VKC’s resolution with puberty have persistently suggested a role of hormonal factors in VKC development. …
Insulin resistance, growth factors and cytokine levels in overweight women with breast cancer before and after chemotherapy
Eftychia Chala, Christos Manes, Helias Iliades, Georgios Skaragkas, Despina Mouratidou, Efthymios Kapantais
OBJECTIVE: To evaluate insulin values, insulin resistance, growth factors and cytokine levels in women suffering from breast cancer and the effect of chemotherapy on these parameters. DESIGN: In a prospective study, glucose and insulin values were determined in ten previously undiagnosed diabetic postmenopausal women with stage IV breast cancer (hepatic metastases excluded) during an oral glucose tolerance test …
Combined therapy with L-Thyroxine and L-Triiodothyronine compared to L-Thyroxine alone in the treatment of primary hypothyroidism
Valentine V. Fadeyev, Tatyana B. Morgunova, Galina A. Melnichenko, Ivan I. Dedov
Objective: The objective of this study was to compare various parameters in patients with hypothyroidism receiving either monotherapy with L-Thyroxine (L-T4) or combination therapy with L-T4 and L-Triiodothyronine (L-T3). Design: We conducted a randomized, controlled trial in 36 premenopausal women with hypothyroidism …
The associations of polymorphisms of TSH receptor and thyroid hormone receptor genes with L-thyroxine treatment in hypothyroid patients
Sayer I. Al-Azzam, Karem H. Alzoubi, Omar Khabour, Ola Al-Azzeh
OBJECTIVE: To investigate the possible association between response to levothyroxine (L-T4) doses in hypothyroid patients and variation in thyroid stimulating hormone receptor (TSHR) gene and thyroid hormone receptor (THRα) gene …
Multiple pituitary hormone abnormalities, fever, behavioral problems, seizures and apnoic spells in a 6-year old girl
Kyriaki Karavanaki, Andriani Divoli, Mehul Dattani, George Briassoulis, Virginia Theodorou, Vasiliki Hatzara, Spyros Avlonitis
A 6-year old girl was examined having two years previously presented a transient Cushing’s syndrome, followed by recurrent hyponatremia, attributed to inappropriate ADH secretion (SIADH). The brain MRI showed no abnormalities on repeated examinations, except for a suggestion of empty sella syndrome. During the past two years she also presented recurrent episodes of a prolonged febrile illness of unknown origin…