Radioactivity and thyroid cancer*

Christopher Reiners

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There is no evidence that natural radiation (cosmic radiation or from natural radioiosotopes) increases the risk for thyroid diseases. Moreover, while it has been proven that exposure to external medical radiation or to external and internal radiation by atomic bomb explosions leads to an increased risk for thyroid cancer …

Differentiated thyroid cancer in children and adults: same or distinct disease?

Barbara Jarzab, Daria Handkiewicz-Junak

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Differentiated thyroid cancer (Dtc) is a rare disease, especially in children. Differences in the biology and clinical course of Dtc in children, when compared with adults, may be related both to pathogenesis as well as to clinical outcome of the disease. In childhood, the thyroid gland exhibits higher susceptibility to the carcinogenetic …

Ten-Year obesity and overweight prevalence in Greek children: A systematic review and meta-analysis of 2001-2010 data

Eleni P. Kotanidou, Maria G. Grammatikopoulou, Bessie E. Spiliotis, Christina Kanaka-Gantenbein, Maria Tsigga, Assimina Galli-Tsinopoulou

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OBJECTIVE: While the US today has the highest rates worldwide of obesity, Europe, and particularly Southern Europe, is catching up fast. The aim of this study was to report the prevalence of obesity in Greek children, aged 1-12 years. DESIGN: A systematic review—including all studies published in English and Greek …

Thyroid carcinoma in children and adolescents. Presentation, clinical course, and outcome of therapy in 23 children and adolescents in Northern Greece

Kalliopi Pazaitou-Panayiotou, Athina Kaprara, Maria Boudina, Eleni Georgiou, Apostolos Drimonitis, Ekaterini Raptou, Grammati Galaktidou, Iraklis Vainas

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OBJECTIVE: To define clinical presentation, surgical complications, follow-up characteristics, and survival of 23 children and adolescents with thyroid carcinoma. DESIGN: Retrospective analysis of data of 23 children and adolescents with thyroid carcinoma cared for in the Theagenion Cancer Hospital, Thessaloniki…

Decreased circulating 25-(OH) Vitamin D concentrations in obese female children and adolescents: Positive associations with Retinol Binding Protein-4 and Neutrophil Gelatinase-associated Lipocalin

Dimitra Metheniti, Sophia Sakka, Maria Dracopoulou, Alexandra Margeli, Ioannis Papassotiriou, Christina Kanaka-Gantenbein, George P. Chrousos, Panagiota Pervanidou

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OBJECTIVE: Hypovitaminosis D has been associated with adult as well as childhood obesity. Retinol-binding-protein-4 (RBP-4) and Neutrophil Gelatinase-associated Lipocalin (NGAL) are altered in obese individuals. The aim of this study was to examine circulating 25-(OH) Vitamin D (25-(OH) D) concentrations …

Increased placental growth factor (PlGF) concentrations in children and adolescents with obesity and the metabolic syndrome

Panagiota Pervanidou, Giorgos Chouliaras, Athanassios Akalestos, Despoina Bastaki, Filia Apostolakou, Ioannis Papassotiriou, George P. Chrousos

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OBJECTIVE: Childhood obesity and the Metabolic Syndrome (MetS) are associated with an increased risk for early onset endothelial dysfunction and atherosclerosis. Placental growth factor (PlGF), a member of the vascular endothelial growth factor family, plays an important role in atherosclerosis by stimulating angiogenesis …

Increased prevalence of growth hormone deficiency in patients with vernal keratoconjuntivitis; An interesting new association

Stefano Stagi, Neri Pucci, Laura di Grande, Cinzia de Libero, Roberto Caputo, Stefano Pantano, Salvatore Seminara, Maurizio de Martino, Elio Novembre

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INTRODUCTION: Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis that mainly affects children living in temperate areas. The notable difference between genders and VKC’s resolution with puberty have persistently suggested a role of hormonal factors in VKC development. …

Sociodemographic, ethnic and dietary factors associated with childhood obesity in Thessaloniki, Northern Greece

Maria Hassapidou, Sousana K. Papadopoulou, Athanasios Frossinis, Ioannis Kaklamanos, Themistoklis Tzotzas

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OBJECTIVE: To investigate sociodemographic, ethnic and dietary factors associated with the development of childhood obesity. DESIGN: 276 children, aged 8-12 years, randomly selected from seven schools in Thessaloniki, Northern Greece, participated in the study. 13% of the children were immigrants from neighboring Balkan countries and ex-Soviet Union countries …

Auxologic parameters and response to 2-year therapy with recombinant human growth hormone in growth hormone deficient children with an ectopic posterior pituitary

Maria Kalina, Barbara Kalina-Faska, Katarzyna Gruszczyńska, Jan Baron, Anita Cisowska, Karolina Morawiec, Paulina Biel-Lewandowska, Ewa Małecka-Tendera

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BACKGROUND: Structural defects of the hypothalamic-pituitary area in MRI are suggested as being a more accurate marker of growth hormone deficiency (GHD) than laboratory assays. OBJECTIVE: To compare auxological characteristics in GHD children with normal pituitary (NP) function and with ectopic posterior pituitary (EPP) …

Monitoring of lipodystrophic and metabolic abnormalities in HIV-1 infected children on antiretroviral therapy

Vana Spoulou, Christina Kanaka-Gantenbein, Irini Bathrellou, Stefano Mora, Glyceria Mostrou, Lambros Sidossis, George Chrousos, Maria Theodoridou

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OBJECTIVE: Few studies have thus far assessed body composition by dual energy X-ray absorptrometry (DXA) in children with HIV, primarily because reference data for normally growing children and adolescents are not available. Our study aimed at evaluating body composition in children with HIV and their relatiοn to serum lipids and glucose homeostasis …

Normal lumbar bone mineral density in optimally treated children and young adolescents with β-thalassaemia major

Athanasios Christoforidis, Eirini Kazantzidou, Ioanna Tsatra, Haido Tsantali, George Koliakos, Emmanouil Hatzipantelis, George Katzos, Miranda Athanassiou-Metaxa

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OBJECTIVE: Osteopenia/osteoporosis of multi-factorial pathogenetic mechanism is reported to be a significant cause of morbidity in adult patients with β-thalassaemia major. Even in young patients, decreased Bone Mineral Density (BMD) values are a consistent finding in the literature. This study was performed in order to assess BMD …

Internalizing and externalizing problems in obese children and adolescents: associations with daily salivary cortisol concentrations

Panagiota Pervanidou, Despoina Bastaki, Giorgos Chouliaras, Katerina Papanikolaou, Christina Kanaka-Gantenbein, George Chrousos

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OBJECTIVE: Pediatric obesity commonly co-exists with emotional and behavioral disorders, while disturbed cortisol concentrations have been reported in both obese and chronically stressed individuals with anxiety and/or depression. We investigated the prevalence of internalizing and externalizing problems …

Parental involvement does not augment the effectiveness of an intense behavioral program for the treatment of childhood obesity

Eirini Bathrellou, Mary Yannakoulia, Katerina Papanikolaou, Artemios Pehlivanidis, Panagiota Pervanidou, Christina Kanaka-Gantenbein, Ioanna Tokou, John Tsiantis, George P. Chrousos, Labros S. Sidossis

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OBJECTIVE: To evaluate the effectiveness of active parental involvement in a lifestyle intervention for the management of childhood obesity. DESIGN: Forty-two overweight children (32 girls and 10 boys), aged 9.2±0.2 years and with percent overweight 39.8±2.7%, were randomly allocated either to a child-and-parent group …