Gemma Sesmilo, Irene Halperin, Manuel Puig-Domingo
Brain injury (BI), both head trauma (TBI) and subarachnoid hemorrage (SAH), has consistently been recognized as an important cause of pituitary dysfunction.1 Different studies have estimated that 20-50% of patients who have suffered BI will develop some degree of hypopituitarism.1-9 The high incidence of BI ranks it as potentially the most important cause of hypothalamic-pituitary dysfunction…
Orsolya Nemes, Noemi Kovacs, Endre Czeiter, Peter Kenyeres, Zita Tarjanyi, Laszlo Bajnok, Andras Buki, Tamas Doczi, Emese Mezosi
OBJECTIVE: There is increasing awareness among physicians of the risks of traumatic brain injury (TBI)-induced hypopituitarism. We have assessed the prevalence and risk factors of post-traumatic hypopituitarism by analyzing the TBI database of the University of Pecs …
Vladimir Jovanovic, Sandra Pekic, Marko Stojanovic, Goran Tasic, Branko Djurovic, Ivan Soldatovic, Mirjana Doknic, Dragana Miljic, Marina Djurovic, Milica Medic-Stojanoska, Vera Popovic
OBJECTIVE: Subarachnoid hemorrhage (SAH) is a recently identified risk factor for hypopituitarism, particularly growth hormone (GH) and corticotrophins deficiencies. The aim of our study was to identify possible predictor(s) for neuroendocrine dysfunction in SAH survivors. DESIGN: Pituitary function was evaluated in 93 patients …
Mirjana Doknic, Sandra Pekic, Milorad Civcic, Vera Popovic
CONTEXT: Congenital hypopituitarism is a syndrome which is associated with single or multiple pituitary hormone deficiencies. Mutations in a number of developmental genes have been linked to combined pituitary hormone deficiencies, the most common being mutation in the pituitary …
Maria Andrikoula, Amalia Sertedaki, Sofia Andrikoula, Catherine Dacou-Voutetakis, Agathocles Tsatsoulis
PROP-1 gene mutations have been reported as a cause of combined pituitary hormone deficiency. Physical and hormonal phenotypes of affected individuals are variable. We report a 63-year-old female who presented with osteoporosis
Guo-li Du, Zhong-hua Liu, Min Chen, Rui Ma, Sheng Jiang, Miriguli Shayiti, Jun Zhu, Aibibai Yusufu
OBJECTIVE: To evaluate the clinical and hormonal characteristics of patients with Sheehan’s syndrome in Xinjiang, China. METHODS: 97 cases diagnosed as Sheehan’s syndrome in our hospital from 1999 to 2013 were retrospectively reviewed …