Journal Articles

Preoperative imaging and localization of small sized insulinoma with EUS-guided fine needle tattoing: a case report

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George N. Zografos, Alexandra Stathopoulou, George Mitropapas, John Karoubalis, George Kontogeorgos, Gregory Kaltsas, George Piaditis, George I. Papastratis

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We report a case of an insulinoma that was not identified on either Computerized Tomography (CT) scan and Magnetic Resonance Imaging (MRI). Endoscopic ultrasonography (EUS) revealed a small insulinoma located at the body of the pancreas, which was histologically confirmed. The patient underwent a laparotomy but no tumour was identified either on palpation or with intra-operative ultrasound …

Severity of coronary artery disease in postmenopausal diabetic women

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Katerina Saltiki, Adrianna Cimponeriu, Kyriaki Lili, Melpomeni Peppa, Eleni Anastasiou, Maria Alevizaki

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Objective: Coronary artery disease (CAD) risk increases in women after the menopause. The aim of this study was to determine the effect of diabetes on the severity of CAD in postmenopausal women undergoing coronary angiography. Design: 180 postmenopausal women underwent coronary angiography for suspected CAD …

Gonadotroph pituitary macroadenoma inducing ovarian hyperstimulation syndrome: successful response to octreotide therapy

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Olga Karapanou, Marinella Tzanela, Nikolaos Tamouridis, Stylianos Tsagarakis

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We report a young woman with spontaneous ovarian hyperstimulation syndrome (OHSS), headaches, visual field defect and pituitary macroadenoma. She underwent transsphenoidal surgery with remission of OHSS. Immunohistochemical staining was positive for β-FSH and β-LH …

Bone mineral status and metabolism in patients with Williams-Beuren syndrome

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Stefano Stagi, Cristina Manoni, Perla Scalini, Francesco Chiarelli, Alberto Verrotti, Cecilia Cecchi, Elisabetta Lapi, Sabrina Giglio, Silvia Romano, Maurizio de Martino

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OBJECTIVE: To evaluate bone mineral status and metabolism in a cohort of patients with Williams-Beuren syndrome (WBS). PATIENTS: Thirty-one children (15 females, 16 males; mean age 9.6±2.74 years) and 10 young adults (6 females, 4 males; mean age 21.4±5.11 years) with WBS were cross-sectionally evaluated and compared with two age-, sex-, and body-size-matched paediatric …

Langerhans’ cell histiocytosis in an adult patient manifested as recurrent skull lesions and Diabetes Insipidus

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Polyzois Makras, Dimitris Papadogias, Chrysoula Samara, Athanasios Zetos, Gregory Kaltsas, George Piaditis, Antony C Chu

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We describe a 57-year old female with the diagnosis of skull and meningeal Langerhans’ cell histiocytosis who was treated with the combination of azathioprine and methotrexate. Although the skull lesions improved considerably on this regimen, the patient developed diabetes insipidus while the anterior pituitary function remained intact…

The response of corticotropin and adrenal steroids to desmopressin stimulation in patients with various forms of hypercortisolism

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Eugenia I. Marova, Nikolay P. Goncharov, Galina S. Kolesnikova, Svetlana D. Arapova, Anastasiya M. Lapshina

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OBJECTIVE: The purpose of this study was to evaluate the direct action of desmopressin (agonist of vasopressin) on the hypophysis and the three zones of the adrenal cortex in patients with different forms of hypercortisolism. DESIGN: Forty-three patients with hypercortisolism—21 with Cushing’s disease (14 females, 7 males), 11 with extrapituitary …

Sex steroids and personality traits in the middle luteal phase of healthy normally menstruating young professional women

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Pavlina D. Avgoustinaki, Effrosyni Mitsopoulou, Gregorios Chlouverakis, Theoni Triantafillou, Maria Venihaki, Sofia Koukouli, Andrew N. Margioris

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OBJECTIVE: Sex steroids affect human behavior. The aim of the present study was to determine the associations, if any, between the circulating levels of gonadal and adrenal sex steroids in the mid luteal phase (21st day of a normal menstrual cycle, MC) of young professional …

Calcium homeostasis in women with non-metastatic breast cancer with osteoporosis after a single dose of denosumab: a pilot study

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Konstantinos Toulis, Paschalia Iliadou, Stylianos Mandanas, Polyzo Kazila, Efterpi Margaritidou, Konstantinos Georgopoulos, Kalliopi Pazaitou-Panayiotou

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Along with achieving a reduction in the incidence of osteoporotic fractures, denosumab (a human monoclonal antibody against the receptor activator of nuclear factor kappa-B ligand (RANKL) causes conformational changes in the calcium-sensing receptor (CaSR), leading to parathyroid hormone exocytosis …

The role of Hemochromatosis C282Y and H63D mutations in the development of type 2 diabetes mellitus in Greece

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Ioannis G Habeos, Agathoklis Psyrogiannis, Venetsana Kyriazopoulou, A Psilopanagiotou, Athanasios G Papavassiliou, Apostolos G Vagenakis

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Several authors have suggested a positive association between diabetes type 2 (DM2) and the C282Y and H63D mutations of the hereditary hemochromatosis gene but others have disputed it. There are also papers reporting an increased iron load in diabetes type 2 and a possible association with the pathogenesis of the disease …

Alterations of coagulation in metformin intoxication

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Baris Akinci, Serkan Yener, Goksel Bengi, Sena Yesil

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It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and after recovery…

Prediction of maternal and neonatal adverse outcomes in pregnant women treated for hypothyroidism

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Maria K. Poulasouchidou, Dimitrios G. Goulis, Pavlos Poulakos, Gesthimani Mintziori, Apostolos Athanasiadis, Grigorios Grimbizis, Basil C. Tarlatzis

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OBJECTIVE: To examine whether the concentrations of maternal serum TSH and free thyroxine (fT4) through pregnancy, the presence of thyroid autoimmunity (TAI) or the dose of levo-thyroxine (LT4) replacement can predict the occurrence of maternal or fetal/neonatal complications in pregnant women …

Which type 2 diabetes mellitus patients should be screened for subclinical Cushing’s syndrome?

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Güven Barış Cansu, Sevgi Atılgan, Mustafa Kemal Balcı, Ramazan Sarı, Sebahat Özdem, Hasan Ali Altunbaş

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OBJECTIVE: Diabetes or impaired glucose tolerance are common in patients with Cushing’s syndrome (CS). In this study we investigated the incidence of subclinical Cushing’s syndrome (SCS) in type 2 diabetic patients with poor and good metabolic control and the relationship between blood glucose and cortisol levels. DESIGN: A total of 400 type 2 diabetes mellitus (T2DM) patients (Group A, HbA1c ≥8%, n=250; Group B, HbA1c ≤6.5%, n=150) were included in the study …

A unique case of a benign adrenocortical tumor with triple secretion of cortisol, androgens, and aldosterone. Development of multiple sclerosis after surgical removal of the tumor

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Athina Markou, Kaity Tsigou, Dimitrios Papadogias, Kostas Kossyvakis, Kyriakos Vamvakidis, Theodora Kounadi, George Piaditis

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We present a 39-year old female with a benign adrenal tumor characterized by autonomous secretion of cortisol, androgens, and aldosterone. The patient presented with a 4-year history of hypertension and severe hirsutism. Baseline investigations revealed elevated testosterone, androstendione, and 17OH progesterone with normal levels of dehydroepiandrosterone sulfate…

Sociodemographic, ethnic and dietary factors associated with childhood obesity in Thessaloniki, Northern Greece

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Maria Hassapidou, Sousana K. Papadopoulou, Athanasios Frossinis, Ioannis Kaklamanos, Themistoklis Tzotzas

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OBJECTIVE: To investigate sociodemographic, ethnic and dietary factors associated with the development of childhood obesity. DESIGN: 276 children, aged 8-12 years, randomly selected from seven schools in Thessaloniki, Northern Greece, participated in the study. 13% of the children were immigrants from neighboring Balkan countries and ex-Soviet Union countries …

Salivary cortisol day curves in assessing glucocorticoid replacement therapy in Addison’s disease

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Lisanne Smans, Eef Lentjes, Ad Hermus, Pierre Zelissen

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OBJECTIVE: Patients with Addison’s disease require lifelong treatment with glucocorticoids. At present, no glucocorticoid replacement therapy (GRT) can exactly mimic normal physiology. As a consequence, under- and especially overtreatment can occur. Suboptimal GRT may lead to various side effects …

Adverse effects of androgen deprivation therapy in patients with prostate cancer: focus on metabolic complications

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Vasileios Tzortzis, Michael Samarinas, Ioannis Zachos, Athanasios Oeconomou, Louis L. Pisters, Alexandra Bargiota
 

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Prostate cancer is the most common cancer among men and androgen deprivation therapy (ADT) is the most effective treatment for this disease. The cornerstone of the treatment of prostate cancer is inhibition of testosterone production which interrupts testosterone-induced growth of the prostate tumor. The dramatic decrease in testosterone levels …

Growth hormone deficiency associated with moyamoya disease in a 16 year-old boy

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Maria Kalina, Barbara Kalina-Faska, Katarzyna Wojaczynska-Stanek, Ewa Malecka-Tendera, Elzbieta Marszal

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Moyamoya disease is a rare cerebrovascular disorder which, according to a few literature reports, can coexist with hypothalamic-pituitary dysfunction. We report a 16 year-old boy referred to our Department because of short stature and headaches. He additionally, at admission, presented discrete facial dysmorphy, bruxism, luxation of temporomandibular joint …

Laparoscopic sleeve gastrectomy in morbidly obese patients. Technique and short term results

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Andreas Kiriakopoulos, Christos Varounis, Dimitrios Tsakayannis, Dimitrios Linos

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Objective: To evaluate the efficacy of Laparoscopic Sleeve Gastrectomy (LSG) as a definitive procedure for morbidly obese patients. Design: This constitutes a prospective study carried out in a tertiary care private hospital and included 15 morbidly obese patients who underwent LSG …

Association of physical activity and sedentary lifestyle patterns with obesity and cardiometabolic comorbidities in Greek adults: Data from the National Epidemiological Survey

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Maria Hassapidou, Sousana K. Papadopoulou, George Vlahavas, Efthymios Kapantais, Daphne Kaklamanou, Ioannis Pagkalos, Myrto Kaklamanou, Themistoklis Tzotzas

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OBJECTIVE: To investigate the association between physical activity (PA) and sedentary lifestyle (SL) patterns with overweight (OW), obesity (OB), abdominal obesity (AO) and cardiometabolic comorbidities in Greek adults based on data from the National Epidemiological Survey for the prevalence of obesity …

Regulation of basal metabolic rate in uncomplicated pregnancy and in gestational diabetes mellitus

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Eleftheria Taousani, Dimitra Savvaki, Efrosini Tsirou, Pavlos Poulakos, Gesthimani Mintziori, Menelaos Zafrakas, Basil C. Tarlatzis, Dimitrios Vavilis, Dimitrios G. Goulis

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Basal metabolic rate (BMR) is one of the major components of total energy expenditure (TEE). It is affected by various factors, such as body weight, body composition, age, race/ethnicity, gender, biochemical parameters, physical activity, and health status. Gestational diabetes mellitus (GDM) is the most common metabolic disorder during pregnancy and it increases the risk for health complications …

Growth without growth hormone (GH): A case report

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Polyzois Makras, Dimitris Papadogias, Grigoris Kaltsas, Nikolaos Kaklas, Georgios Piaditis

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Growth without growth hormone (GH) has occasionally been described in patients with organic pituitary pathology, and even more rarely in patients with idiopathic pituitary hormone deficiency. The mechanism of growth without GH remains a mystery. We describe a 17-year old male who grew 38.5 cm in height over a 7-year period, despite the fact that he had established panhypopituitarism…

Thyroid lymphoma: a rare tumor requiring combined management

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Luca Foppiani, Vincenzo Secondo, Anselmo Arlandini, Paolo Quilici, Manlio Cabria, Patrizia Del Monte

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Thyroid lymphoma is a rare disease which occurs mainly in elderly females. Most patients with thyroid lymphoma have Chronic Lymphocytic Thyroiditis (CLT), suggesting a role of chronic antigen stimulation in the development of the disease. We present two cases of thyroid Diffuse Large B-cell Lymphoma (DLBCL) diagnosed after surgery …

Results of the Thyroid Cancer Alliance international patient/survivor survey: Psychosocial/informational support needs, treatment side effects and international differences in care

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Rita Banach, Beate Bartès, Kate Farnell, Harald Rimmele, Joan Shey, Susanne Singer, Frederik A. Verburg, Markus Luster, for the Thyroid Cancer Alliance

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OBJECTIVE: To comprehensively assess the experience of a large, diverse cohort and identify potential care improvements, the Thyroid Cancer Alliance, an international patient/survivor group coalition, surveyed thyroid cancer patients/survivors worldwide …

Prevalence, pathogenesis and management of prediabetes and type 2 diabetes mellitus in patients with polycystic ovary syndrome

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Sofia Lazaridou, Konstantinos Dinas, Konstantinos Tziomalos

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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. PCOS is not only the leading cause of anovulatory infertility but is also associated with an array of metabolic disorders, among which impaired glucose metabolism has been a topic of intense research. The aim of the present narrative review is to summarize the findings of the studies that have evaluated the prevalence and incidence of prediabetes and type 2 diabetes mellitus …

The Influence of Serum Cortisol Levels on Growth Hormone Responsiveness to GH-Releasing Hormone Plus GH-Releasing Peptide-6 in Patients with Hypocortisolism

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Sandra Pekic, Mirjana Doknic, Marina Djurovic, Svetozar Damjanovic, Milan Petakov1 Dragana Miljic, Carlos Dieguez, Felipe F Casanueva, Vera Popovic

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The aim of this study was to evaluate the influence of circulating cortisol levels on the somatotroph responsiveness to the most potent stimuli of growth hormone (GH) secretion, the GHRH+GHRP-6 test. We studied 12 patients with hypocortisolism (10 with Addison’s disease and 2 with isolated ACTH deficiency) before and after glucocorticoid (GC) replacement therapy and compared …