Is the 250 μg ACTH test a useful tool for the diagnosis of central hypoadrenalism in adult patients with pituitary disorders?

Emanuele Ferrante, Valentina Morelli, Claudia Giavoli, Giovanna Mantovani, Elisa Verrua, Elisa Sala, Elena Malcmiodi, Silvia Bergamaschi, Eriselda Profka,  Elisa Cairoli, Serena Palmieri, Iacopo Chiodini, Andrea-Gerardo Lania, Anna Spada, Paolo Beck-Peccoz

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OBJECTIVE: The diagnosis of hypothalamic-pituitary-adrenal insufficiency (HPAI) is a major clinical challenge. The gold standard procedure remains insulin tolerance test (ITT). This study aimed to evaluate the usefulness of standard-dose corticotrophin stimulation test (SDCT) in diagnosing HPAI …