Oncogene-induced senescence in pituitary adenomas and carcinomas

Krystallenia I. Alexandraki, Mohammed Munayem Khan, Harvinder S. Chahal, Nadezhda S. Dalantaeva, Giampaolo Trivellin, Dan M. Berney, Philippe Caron, Vera Popovic, Marija Pfeifer, Suzanne Jordan, Márta Korbonits, Ashley B. Grossman

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OBJECTIVE: The model of “oncogene-induced senescence” (OIS), resulting in cell-proliferation arrest, has recently been suggested as a possible explanation for the non-progression of pituitary tumours to malignancy. The aim of the study was to compare the expression …

What causes a prolactinoma to be aggressive or to become a pituitary carcinoma?

Jana Phillips, Honey E. East, Sarah E. French, Eugen Melcescu, Robert D. Hamilton, William C. Nicholas, Jonathan F. Fratkin, Andrew D. Parent, Gustavo Luzardo, Christian A. Koch

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INTRODUCTION: Malignant prolactinoma is an exceedingly rare endocrine tumor and cannot be diagnosed on histological grounds alone. Similarly to other neuroendocrine tumors such as pheochromocytoma, the mitoses index, Ki-67, p53, and others are utilized in helping understand …