Oncogene-induced senescence in pituitary adenomas and carcinomas

Krystallenia I. Alexandraki, Mohammed Munayem Khan, Harvinder S. Chahal, Nadezhda S. Dalantaeva, Giampaolo Trivellin, Dan M. Berney, Philippe Caron, Vera Popovic, Marija Pfeifer, Suzanne Jordan, Márta Korbonits, Ashley B. Grossman

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OBJECTIVE: The model of “oncogene-induced senescence” (OIS), resulting in cell-proliferation arrest, has recently been suggested as a possible explanation for the non-progression of pituitary tumours to malignancy. The aim of the study was to compare the expression …