Human kallikrein 10 in surgically removed human pituitary adenomas

Fabio Rotondo, Antonio Di Ieva, Kalman Kovacs, Michael D. Cusimano, Luis V. Syro, Eleftherios P. Diamandis, George M. Yousef

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OBJECTIVE: Human kallikrein-like peptidase 10 (KLK10), a serine protease, plays an important role in the regulation of cell proliferation and tumor growth. In this work, we investigated KLK10 immunoexpression in various types of surgically removed human pituitary tumors …

Effect of Temozolomide in a patient with recurring oncocytic gonadotrophic pituitary adenoma

Luis V. Syro, Bernd W. Scheithauer, Leon D. Ortiz, Camilo E. Fadul, Eva Horvath, Fabio Rotondo, Kalman Kovacs

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The patient was a 70-year-old man with a recurrent pituitary tumor. Three surgeries were performed but the tumor recurred. Based on histologic, immunohistochemical and ultrastructural studies, the diagnosis of oncocytic gonadotrophic pituitary adenoma was made. The tumor was a macroadenoma partly immunopositive for LH …