Ghollam-Reza Moshtaghi-Kashanian, Fakhrolmulok Razavi
OBJECTIVE: Recently published animal studies indicate that leptin and ghrelin play a role in puberty initiation and progress as well as in reproduction. The aim of our study was to evaluate the relation of these two hormones to the pubertal maturity and fertility status in patients with β-thalassemia …
George Ioannidis, Melpomeni Peppa, Phivi Rontogianni, Michael Callifronas, Christos Papadimitriou, Georgia Chrysanthopoulou, Lambros Anthopoulos, Matina Kesse, Nicolaos Thalassinos
People with diabetes mellitus type 2 (DM2) have a greater risk for premature morbidity and mortality due to cardiovascular disease than the general population: cardiovascular disease accounts for 75% of deaths in this population group. We examined whether or not the association of clinical cardiovascular risk factors (RF) with both …
Mansour Siavash, Ammar Hassanzadeh Keshteli, Mahin Hashemipour, Masoud Amini
OBJECTIVE: Iodine Deficiency (ID) was for years considered a contributing factor for endemic goiter in Iran. The present study was conducted to assess the goiter prevalence and iodine status in schoolchildren of Isfahan 16 years after the initiation of salt iodization in Iran …
Menelaos L. Batrinos
It is now well established that hyperprolactinaemia is not rare and in the majority of cases is caused by a pituitary tumor, a prolactinoma. However, despite a plethora of relevant publications there are still certain questions that have not been adequately addressed: 1. What is the upper normal level of serum prolactin beyond which the condition should be characterized as hyperprolactinaemia …
Bayrak E., Serter R., Donderici O. ?nternal Medicine Ankara Education and Research Hospital Ankara Turkey Abstract Introduction: Papillary tumors are the most common while medullary thyroid cancer (MTC) is the third most common of all thyroid cancers. We report a case of papillary thyroid carcinoma (PTC) in the right thyroid lobe together with coexistent MTC Read More
Giovanni Corona, Silvia Bianchini, Alessandra Sforza, Linda Vignozzi, Mario Maggi
There is evidence demonstrating that sexual complaints represent the most specific symptoms associated with late onset hypogonadism, while central obesity is the most specific sign. In obese men, hypogonadism can further worsen the metabolic profile and increase abdominal fat …
Maria G. Grammatikopoulou, Eleni P. Kotanidou, Anastasia G. Markaki, Charilaos Stylianou, Assimina Galli-Tsinopoulou, Maria Tsigga, Maria Hassapidou
OBJECTIVE: The aim of the present study was to evaluate by pooled and sensitivity analyses all available data on adolescent overweight/obesity in Cyprus. DESIGN: A thorough literature search determined the studies to be examined using Cypriot adolescent samples …
Maria P. Yavropoulou, Panagoulia Kollia, Dimitris Chatzidimitriou, Stavroula Samara, Lemonia Skoura, John G. Yovos
Osteoporosis is a common disease with a strong genetic component. Several studies have reported the vitamin D receptor (VDR), collagen type I (COL1A1), and LDL receptor-related protein 5 (LRP5) genes as the most likely candidates. However, most of the studies have been carried out in postmenopausal women and older men and show inconsistent results …
Dimitrios G. Goulis, Paschalia K. Iliadou, Athanasios Papanicolaou, Ioannis Georgiou, Anthi Chatzikyriakidou, Spiridon Gerou, Ioannis N. Bontis, Ioannis Papadimas
An 18-year old, phenotypically female individual was examined for primary amenorrhea. Three months before her referral, the patient underwent surgery and a pelvic mass was removed. The physical examination revealed normal female external genitalia, normal breast development, sparse pubic hair and absence of axillary hair…
Silvano Bertelloni, Giampiero I. Baroncelli, Eleonora Dati, Silvia Ghione, Fulvia Baldinotti, Benedetta Toschi, Paolo Simi
BACKGROUND: Short stature represents one of the main features of children with Noonan syndrome. The reason for impaired growth remains largely unknown. OBJECTIVE: To assess GH and IGF1 secretion in children with Noonan syndrome …
Kostas I. Lampropoulos, George Samonis, Panagiotis Nomikos
OBJECTIVE: Evaluation of factors influencing the outcome of microsurgical transsphenoidal surgery in patients harbouring pituitary adenomas as well as of the efficacy and safety of this procedure. DESIGN: A total of 184 consecutive patients with pituitary adenomas …
Allison Pitts, Grace Ih, Meng Wei, Deepti Dhall, Nicholas N. Nissen, Alan Waxman, Run Yu
OBJECTIVE: To examine the clinical utility of 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) for diagnosing whether an adrenal mass is malignant, in contemporary clinical practice. DESIGN: Retrospective medical record review of patients from 2 databases at a large hospital …
Marios Papadakis, Natalie Meurer, Theodora Margariti, Anke Meyer, Norbert Weyerbrock, Cornelia Dotzenrath
OBJECTIVE: The coexistence of familial hypocalciuric hypercalcemia (FHH) and primary hyperparathyroidism (PHPT) is extremely rare. Genetic evidence has demonstrated a causal relationship between FHH and the presence of inactivating mutations in the calcium-sensing receptor gene …
Stefano Stagi, Elisabetta Lapi, Marilena Pantaleo, Giovanna Traficante, Sabrina Giglio, Salvatore Seminara, Maurizio de Martino
OBJECTIVE:SOX3 is located on the long arm of the X chromosome (Xq27.1) and both the under- and over-expression of this gene have been reported in cases of hypopituitarism with or without intellectual disabilities. Nevertheless, only a few cases have as yet been extensively described …
Nick Kontodimopoulos, Anastasia Veniou, Nicholas Tentolouris, Dimitris Niakas
OBJECTIVE: Diabetic foot ulcer is a critical and costly complication of diabetes mellitus. The aim of this study was to assess the psychometric properties of the Greek version of the diabetic foot ulcer scale – short form (DFS-SF). DESIGN: A sample of patients with diabetic foot ulcer (N=110) was surveyed with the DFS-SF …
Ioannis Vakalopoulos, Petros Dimou, Ioannis Anagnostou, Theodosia Zeginiadou
While cancer, and especially testicular cancer and Hodgkin’s disease, affects male fertility in many ways, the current increase of survival of male cancer patients of reproductive age or earlier has emerged as a new challenge to their subsequent ability to father children. Cancer treatments, including surgery, radiotherapy and chemotherapy …
Ana Savic-Radojevic, Ivana Bozic Antic, Vesna Coric, Jelica Bjekic-Macut, Tanja Radic, Milos Zarkovic, Tatjana Djukic, Marija Pljesa-Ercegovac, Dimitrios Panidis, Ilias Katsikis, Tatjana Simic, Djuro Macut
OBJECTIVE: In order to gain deeper insight into molecular mechanisms underlying oxidative stress (OS) and its relation to insulin resistance and hyperandrogenemia, plasma markers of OS and antioxidant glutathione-peroxidase (GPX) activity were studied in non-obese polycystic ovary syndrome (PCOS) women via the oral glucose tolerance test …
Stefano Stagi, Neri Pucci, Laura di Grande, Cinzia de Libero, Roberto Caputo, Stefano Pantano, Salvatore Seminara, Maurizio de Martino, Elio Novembre
INTRODUCTION: Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis that mainly affects children living in temperate areas. The notable difference between genders and VKC’s resolution with puberty have persistently suggested a role of hormonal factors in VKC development. …
Mirjana Doknic, Sandra Pekic, Milorad Civcic, Vera Popovic
CONTEXT: Congenital hypopituitarism is a syndrome which is associated with single or multiple pituitary hormone deficiencies. Mutations in a number of developmental genes have been linked to combined pituitary hormone deficiencies, the most common being mutation in the pituitary …
Ayla Güven, Ayşe Nurcan Cebeci, Suna Hancili
OBJECTIVE: Congenital adrenal hyperplasia (CAH) can be complicated by central precocious puberty (CPP) in children, which may compromise final height. We aimed to evaluate the effect of gonadotropin-releasing hormone analog (GnRHa) therapy on growth in children with CAH …
Nicholas Tentolouris, Alexandros Andrianakos, Georgios Karanikolas, Dimitrios Karamitsos, Panagiotis Trontzas, Petros Krachtis, Fotis Christoyannis, Elpiniki Tavaniotou, Zouboulio Nikolia, Evaggelia Kaskani, Leonidas Kontelis, Petros P. Sfikakis
OBJECTIVE: In this cross-sectional epidemiologic study we examined the association between type 2 diabetes mellitus and demographic, clinical, and socioeconomic parameters in large rural, urban and suburban populations of adult Greeks. DESIGN: Of the total target adult population …
Anastasios Papadimitriou, Dimitrios Chiotis, Georgios Tsiftis, Maria Hatzisimeon, Maria Maniati, Xenofon Krikos, Anastasia Tzonou, Catherine Dacou-Voutetakis
Statural growth is dependent on hereditary and environmental factors, i.e disease, nutrition. The improvement of socioeconomic conditions that took place during the 20th century resulted in a secular trend towards greater height and earlier sexual maturation. Greek society has changed dramatically from a mainly agricultural society …
Rita Banach, Beate Bartès, Kate Farnell, Harald Rimmele, Joan Shey, Susanne Singer, Frederik A. Verburg, Markus Luster, for the Thyroid Cancer Alliance
OBJECTIVE: To comprehensively assess the experience of a large, diverse cohort and identify potential care improvements, the Thyroid Cancer Alliance, an international patient/survivor group coalition, surveyed thyroid cancer patients/survivors worldwide …
Baris Akinci, Serkan Yener, Goksel Bengi, Sena Yesil
It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and after recovery…
Maria Hassapidou, Sousana K. Papadopoulou, Athanasios Frossinis, Ioannis Kaklamanos, Themistoklis Tzotzas
OBJECTIVE: To investigate sociodemographic, ethnic and dietary factors associated with the development of childhood obesity. DESIGN: 276 children, aged 8-12 years, randomly selected from seven schools in Thessaloniki, Northern Greece, participated in the study. 13% of the children were immigrants from neighboring Balkan countries and ex-Soviet Union countries …