The Influence of Serum Cortisol Levels on Growth Hormone Responsiveness to GH-Releasing Hormone Plus GH-Releasing Peptide-6 in Patients with Hypocortisolism

Sandra Pekic, Mirjana Doknic, Marina Djurovic, Svetozar Damjanovic, Milan Petakov1 Dragana Miljic, Carlos Dieguez, Felipe F Casanueva, Vera Popovic

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The aim of this study was to evaluate the influence of circulating cortisol levels on the somatotroph responsiveness to the most potent stimuli of growth hormone (GH) secretion, the GHRH+GHRP-6 test. We studied 12 patients with hypocortisolism (10 with Addison’s disease and 2 with isolated ACTH deficiency) before and after glucocorticoid (GC) replacement therapy and compared …