Luca Foppiani, Vincenzo Secondo, Anselmo Arlandini, Paolo Quilici, Manlio Cabria, Patrizia Del Monte
Thyroid lymphoma is a rare disease which occurs mainly in elderly females. Most patients with thyroid lymphoma have Chronic Lymphocytic Thyroiditis (CLT), suggesting a role of chronic antigen stimulation in the development of the disease. We present two cases of thyroid Diffuse Large B-cell Lymphoma (DLBCL) diagnosed after surgery …
Rita Banach, Beate Bartès, Kate Farnell, Harald Rimmele, Joan Shey, Susanne Singer, Frederik A. Verburg, Markus Luster, for the Thyroid Cancer Alliance
OBJECTIVE: To comprehensively assess the experience of a large, diverse cohort and identify potential care improvements, the Thyroid Cancer Alliance, an international patient/survivor group coalition, surveyed thyroid cancer patients/survivors worldwide …
Sofia Lazaridou, Konstantinos Dinas, Konstantinos Tziomalos
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. PCOS is not only the leading cause of anovulatory infertility but is also associated with an array of metabolic disorders, among which impaired glucose metabolism has been a topic of intense research. The aim of the present narrative review is to summarize the findings of the studies that have evaluated the prevalence and incidence of prediabetes and type 2 diabetes mellitus …
Sandra Pekic, Mirjana Doknic, Marina Djurovic, Svetozar Damjanovic, Milan Petakov1 Dragana Miljic, Carlos Dieguez, Felipe F Casanueva, Vera Popovic
The aim of this study was to evaluate the influence of circulating cortisol levels on the somatotroph responsiveness to the most potent stimuli of growth hormone (GH) secretion, the GHRH+GHRP-6 test. We studied 12 patients with hypocortisolism (10 with Addison’s disease and 2 with isolated ACTH deficiency) before and after glucocorticoid (GC) replacement therapy and compared …
Nectaria Xita, Leandros Lazaros, Ioannis Georgiou, Agathocles Tsatsoulis
OBJECTIVE: Insulin resistance is a key factor in the pathogenesis of polycystic ovary syndrome (PCOS). Peroxisome proliferator-activated-receptor-γ (PPAR-γ) has been implicated in insulin resistance and adiposity. The aim of the study was to investigate the possible involvement of the Pro12Ala polymorphism …
Wei Wang, Xiaobo Yang, Jianbo Liang, Ming Liao, Haiying Zhang, Xue Qin, Linjian Mo, Wenxin Lv, Zengnan Mo
Previous studies have suggested that testosterone levels are linked to a variety of diseases, such as cardiovascular disease, type-2 diabetes, the metabolic syndrome, erectile dysfunction, depression, stroke and osteoporosis. Since cigarette smoking is a major health problem and highly prevalent among men …
Stefano Stagi, Cristina Manoni, Valentina Cirello, Danila Covelli, Sabrina Giglio, Francesco Chiarelli, Salvatore Seminara, Maurizio de Martino
The syndrome of resistance to thyroid hormone (RTH) is characterized by elevated serum free thyroid hormones (FT4 and FT3) in the presence of unsuppressed TSH levels, reflecting resistance to the normal negative feedback mechanisms in the hypothalamus and pituitary …
Alessandro Sindoni, Fausto Famà, Maria Gioffre-Florio, Sergio Baldari
It was with great interest that we read the article titled “Neoadjuvant therapy for advanced pancreatic neuroendocrine tumors: an emerging treatment modality?” by I. Perysinakis et al published in the first issue of 2016 of the Journal …
Maria Kalina, Barbara Kalina-Faska, Katarzyna Gruszczyńska, Jan Baron, Anita Cisowska, Karolina Morawiec, Paulina Biel-Lewandowska, Ewa Małecka-Tendera
BACKGROUND: Structural defects of the hypothalamic-pituitary area in MRI are suggested as being a more accurate marker of growth hormone deficiency (GHD) than laboratory assays. OBJECTIVE: To compare auxological characteristics in GHD children with normal pituitary (NP) function and with ectopic posterior pituitary (EPP) …
Antonio Picarelli, Marco Di Tola, Fabio Tabacco, Mariacatia Marino, Raffaele Borghini, Tania D’Amico, Carla Lubrano, Patrizia Gargiulo
OBJECTIVE: The management of obesity, apart from exercise, mainly involves a calorie restriction regimen. A pharmaceutical treatment is often used to improve patient compliance and diet effectiveness, although several side-effects have previously been described …
Nikolaos D. Roupas, Irene Mamali, Spyros Maragkos, Lydia Leonidou, Anastasia K. Armeni, George K. Markantes, Athanasios Tsekouras, George C. Sakellaropoulos, Kostas B. Markou, Neoklis A. Georgopoulos
OBJECTIVE: To evaluate the effect of prolonged intensive aerobic exercise and acute energy deficit (180 km ultra-marathon race) on serum leptin, adiponectin, resistin and visfatin levels and their association and interaction with serum cortisol and insulin levels in highly trained ultra-endurance runners …
Ioanna Zografou, Christos Sampanis, Eugenia Gkaliagkousi, Fotios Iliadis, Athanasios Papageorgiou, Panagiotis Doukelis, Konstantinos Vogiatzis, Stella Douma
OBJECTIVE: To evaluate the effect of dipeptidyl-peptidase-4 (DPP-4) inhibitor vildagliptin on high sensitivity C-reactive protein (hsCRP) and arterial stiffness (AS) in patients with type 2 diabetes (T2DM). DESIGN: Sixty-four drug-naive diabetic patients, with inadequate glycemic control …
Leonidas H. Duntas
With this original description of a case of hyperthyroidism and exophthalmous, the German physician Carl Adolph von Basedow masterfully described a disorder characterized by a triad of hyperthyroidism, goiter and exophthalmous in a publication that included three cases …
George N. Koukoulis, Christina Sakka, Fotis Katsaros, Maria Goutou, Sofia Tsirona, Efthimia Tsiapali, Aristea Piterou, Ioannis Stefanidis, Nikolaos Stathakis
OBJECTIVE: To investigate the prevalence of obesity in adults of a large region of Central Greece. DESIGN: The target group was adults aged 18 to 79 years who were residents of the region of Thessaly for at least one year. A sample of 852 individuals stratified for sex and age were included. Each subject underwent a thorough physical examination and body mass index …
Mohsen Taghizadeh, Zatolla Asemi
OBJECTIVE: The aim of this study was to determine the effects of synbiotic food consumption on glycemic status and serum high sensitivity C-reactive protein (hs-CRP) levels of Iranian pregnant women. DESIGN: This randomized placebo-controlled clinical trial was performed among 52 pregnant women …
Menalaos L. Batrinos
Many ancients held various beliefs about the supernatural virtues of certain numbers. In ancient Greece, the school of Pythagoras (590 BC) taught the doctrine of the numerical essence of natural events. In accordance with this theory, the number 7 was considered a sacred number and thus vital to human life…
Rosaria M. Ruggeri, Giovanni Smedile, Francesca Granata, Marcello Longo, Salvatore Cannaíò, Nicholas J. Sarlis, Francesco Trimarchi, Salvatore Benvenga
OBJECTIVE. Hypopituitarism is a recognized complication of Traumatic Brain Injury (TBI). Resolution of established anterior pituitary hormones deficiency is rare. CASE REPORT. A woman was initially presented at the age of 22 years with amenorrhoea. Two years earlier she had been involved in a car accident with consequent TBI …
Natalia Lazopoulou, Eleana Gkioka, Ioanna Ntalla, Panagiota Pervanidou, Alexandra-Maria Magiakou, Eleftheria Roma-Giannikou, George P. Chrousos, Ioannis Papassotiriou, George Dedoussis, Christina Kanaka-Gantenbein
OBJECTIVE: Single nucleotide polymorphism (SNP) risk alleles of obesogenic genes, such as the fat mass and obesity-associated protein (FTO) and the melanocortin-4 receptor (MC4R) gene, have been described in both paediatrics and adult populations …
Katherine E. Akester, Noel Somasundaram, Salvador Diaz-Cano, Ashley B. Grossman
Most clinicians assume that a thyroid mass which appears to be malignant is most likely a tumour arising from thyroid cells. We present a case where the thyroid malignancy was associated with a degree of systemic clinical and biochemical disturbance which suggested alternative diagnoses, and in which fine-needle aspiration revealed that the patient had a thyroid lymphoma …
Edavan P. Praveen, Bindu Kulshreshtha, Madan L. Khurana, Jayaprakash Sahoo, Nandita Gupta, Guresh Kumar, Ariachery C. Ammini, Rajech Knadgawat
Objective: Offspring of type 2 diabetics have an increased risk of dyslipidemia, glucose intolerance and obesity. The aim of this study was to assess the lipid levels in the offspring of diabetics with normal glucose tolerance and normal body weight. Design: Normal weight offspring of patients with type 2 diabetes mellitus (DM) who had normal glucose tolerance …
Silvia Santos-Palacios, Antonio Brugos-Larumbe, Francisco Guillén-Grima, Ane Garmendia-Madariaga, Juan C. Galofré
OBJECTIVE: In the last few years a number of studies have found that metformin has a thyrotropin (TSH)-lowering effect in patients with type 2 diabetes (DM2) and that this effect disappears after discontinuation of the drug. Initial studies were carried out in hypothyroid patients on levothyroxine (LT4) treatment …
Irene V. Lambrinoudaki, Olga D. Daskalaki, Stathis A. Thomopoulos, Panayiotis Schinochoritis, Argyris B. Argyropoulos
A 26-year old symptom-free woman was admitted to our Clinic for evaluation of hyperprolactinemia. The patient, who had normal menstrual cycles, was found accidentally to have a cystic adnexal mass and was placed on oral contraceptives (OC) for 3 months. During the first OC-cycle a bilateral breast nipple discharge was noticed and an elevated serum prolactin (PRL) was detected (2.7 nmol/l) …
Vana Spoulou, Christina Kanaka-Gantenbein, Irini Bathrellou, Stefano Mora, Glyceria Mostrou, Lambros Sidossis, George Chrousos, Maria Theodoridou
OBJECTIVE: Few studies have thus far assessed body composition by dual energy X-ray absorptrometry (DXA) in children with HIV, primarily because reference data for normally growing children and adolescents are not available. Our study aimed at evaluating body composition in children with HIV and their relatiοn to serum lipids and glucose homeostasis …
Dimitrios Panidis, Konstantinos Tziomalos, Efstathios Papadakis, Panagiotis Chatzis, Eleni A. Kandaraki, Elena A. Tsourdi, Djuro Macut, Jelica Bjekic-Macut, Apostolos Marthopoulos, Ilias Katsikis
OBJECTIVE: Limited data suggest that menstrual cycle abnormalities are more pronounced in younger and more obese patients with polycystic ovary syndrome (PCOS). We aimed to evaluate the association between menstrual cycle pattern and age, obesity and PCOS phenotype in a large population of women with PCOS …
Evangeline Vassilatou, Panayiotis Schinochoritis, Stamatina Marioli, Ioanna Tzavara
A 21-year old man, complaining of headaches and fatigue, with a negative past medical history and a normal clinical examination, underwent a hormonal investigation which revealed hyper-prolactinemia and intact pituitary-gonadal axis. Drug-induced hyperprolactinemia was excluded …