Polycystic Ovary Syndrome: The influence of environmental and genetic factors

Evanthia Diamanti-Kandarakis, Christina Piperi, Georgia Argyrakopoulou, Jiovanna Spina, Lambrini Papanastasiou, Angeliki Bergiele, Dimitrios Panidis

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Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder characterized by hyperandrogenemia, hyperinsulinemia, insulin resistance, and chronic anovulation. It is the most common endocrine disorder in women of reproductive age with an enigmatic pathophysiologic and molecular basis. The high prevalence of affected …

The combined effect of MC4R and FTO risk alleles on childhood obesity in Greece

Natalia Lazopoulou, Eleana Gkioka, Ioanna Ntalla, Panagiota Pervanidou, Alexandra-Maria Magiakou, Eleftheria Roma-Giannikou, George P. Chrousos, Ioannis Papassotiriou, George Dedoussis, Christina Kanaka-Gantenbein

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OBJECTIVE: Single nucleotide polymorphism (SNP) risk alleles of obesogenic genes, such as the fat mass and obesity-associated protein (FTO) and the melanocortin-4 receptor (MC4R) gene, have been described in both paediatrics and adult populations …