Author: admin

Primary Adrenal lymphoma presented with adrenal insufficiency

Posted on by

Evanthia Diamanti-Kandarakis, Pantelis Chatzismalis, Frangiskos Economou, Stefanos Lazarides, Athena Androulaki, Grigorios Kouraklis

Download PDF

We report a 71-year old man who presented with symptoms of adrenal insufficiency and large bilateral adrenal masses. Computed tomography guided FNA biopsy was not diagnostic. However, because of the rapid growth of the masses, the negative workup for primary malignancy and the strong clinical suspicion of a lymphoma, an open biopsy was performed and a B-cell lymphoma was disclosed…

A female infant with Silver Russell Syndrome, mesocardia and enlargement of the clitoris

Posted on by

Assimina Galli-Tsinopoulou, Eleftheria Emmanouilidou, Paraskevi Karagianni, Maria Grigoriadou, John Kirkos, George S. Varlamis

Download PDF

Silver Russell Syndrome (SRS) is a rare condition (1/3000 – 1/100,000 newborns). We present a female infant with SRS, cardiac malposition and asymmetric enlargement of the clitoris. She is the first child of Greek nonconsanguinous parents, born at 38 weeks gestation …

Parental involvement does not augment the effectiveness of an intense behavioral program for the treatment of childhood obesity

Posted on by

Eirini Bathrellou, Mary Yannakoulia, Katerina Papanikolaou, Artemios Pehlivanidis, Panagiota Pervanidou, Christina Kanaka-Gantenbein, Ioanna Tokou, John Tsiantis, George P. Chrousos, Labros S. Sidossis

Download PDF

OBJECTIVE: To evaluate the effectiveness of active parental involvement in a lifestyle intervention for the management of childhood obesity. DESIGN: Forty-two overweight children (32 girls and 10 boys), aged 9.2±0.2 years and with percent overweight 39.8±2.7%, were randomly allocated either to a child-and-parent group …

Parathyroid carcinoma as a challenging diagnosis: Report of three cases

Posted on by

Alfredo Campennì, Rosaria Maddalena Ruggeri, Alessandro Sindoni, Salvatore Giovinazzo, Letterio Calbo, Antonio Ieni, Maurizio Monaco, Giovanni Tuccari, Salvatore Benvenga, Sergio Baldari

Download PDF

Parathyroid carcinoma (PC) is a rare malignancy with an indolent but progressive course. This rare tumour is often difficult to diagnose preoperatively, thus limiting the efficacy of surgery. As long-term survival is largely dependent on the extent of the primary surgical resection …

Non tumoral hyperserotoninaemia responsive to octreotide due to dual polymorphism in UGT1A1 and UGT1A6

Posted on by

Anna Maladaki, Maria P. Yavropoulou, Kalliopi Kotsa, Theoni Tranga, Stelios Ventis, John G. Yovos

Download PDF

Gilbert’s syndrome is a common inherited metabolic disorder, caused by genetic aberration in the enzyme UDP-glucuronosyl-transferase 1A1 that leads to reduced glucuronidation of bilirubin. Recent advances in molecular genetics have frequently reported the concurrence of dual genetic …

Growth hormone deficiency in a patient with autoimmune polyendocrinopathy type 2

Posted on by

Asteroula Papathanasiou, Eleni Kousta, Vasiliki Skarpa, Petros Papachileos, Vasilios Petrou, Charalambos Hadjiathanasiou

Download PDF

Autoimmune polyglandular syndrome (APs) type 2 is characterized by the presence of Addison’s disease, in association with autoimmune thyroid disease and/or type 1 diabetes mellitus and is rare in children. A 12.5yr old prepubertal boy presented with symptoms related to Addison’s disease and a large goiter. He was euthyroid with positive thyroid antibodies, low cortisol, aldosterone and very high adrenocorticotropin …

Hypokalemic paralysis following administration of intravenous methylprednisolone in a patient with Graves’ thyrotoxicosis and ophthalmopathy

Posted on by

Stelios Tigas, Petros Papachilleos, Nikolaos Ligkros, Maria Andrikoula, Agathocles Tsatsoulis

Download PDF

Glucocorticoids are commonly used in the treatment of patients with thyroid disorders, in particular Graves’ ophthalmopathy. Thyrotoxic hypokalemic periodic paralysis (TPP) is an infrequent but potentially serious condition characterised by recurrent episodes of weakness associated with hypokalemia …

Severe hypothyroidism due to autoimmune thyroiditis in a child: a one-year follow-up

Posted on by

Francesco Vierucci, Graziano Cesaretti

Download PDF

Autoimmune thyroiditis is considered to be the most common autoimmune condition, with a female preponderance of 2:1. While its overall prevalence peaks in adulthood, autoimmune thyroiditis may affect children and adolescents, particularly during early to mid-puberty …

Familial paraganglioma: A novel presentation of a case and response to therapy with radiolabelled MIBG

Posted on by

Justin K. Lawrence, Eamonn R. Maher, Richard Sheaves, Ashley B. Grossman

Download PDF

Phaeochromocytomas (PC) and paragangliomas are disorders of the sympatho-adrenomedullary system. They are chromaffin-containing neuroendocrine tumors of neural crest origin that contain catecholamine-secreting granules: they arise from either the adrenal medulla (phaeochromocytomas) or from extra-adrenal neural crest derivatives e.g. the sympathetic chain (paragangliomas)…

The differential impact of volatile and intravenous anaesthetics on stress response in the swine

Posted on by

Georgia Kostopanagiotou, Konstantinos Kalimeris, Kalliopi Christodoulaki, Constantinos Nastos, Nikolaos Papoutsidakis, Cleanthi Dima, Charalampos Chrelias, Ageliki Pandazi, Iordanis Mourouzis, Constantinos Pantos

Download PDF

OBJECTIVE: To compare the effects of various anaesthetics on stress response in the presence and absence of surgical stimulation. DESIGN: Twenty-nine pigs scheduled to undergo surgical central vein catheter placement were randomly allocated to receive only sedation with ketamine-midazolam (group SHAM, n=5) or general anaesthesia …

Papillary thyroid cancer in a struma ovarii: a report of a rare case

Posted on by

Eleonora Monti, Lorenzo Mortara, Simonetta Zupo, Mariella Dono, Francesco Minuto, Mauro Truini, Mehrdad Naseri, Massimo Giusti

Download PDF

After removal of an ovarian mass in a 43-year-old woman, a struma ovarii was diagnosed. Within this teratoma, a papillary thyroid cancer was found. The tumor was negative for BRAF, NRAS, KRAS, PIK3CA and c-KIT mutations on molecular analysis …

A novel truncating AIP mutation, p.W279*, in a familial isolated pituitary adenoma (FIPA) kindred

Posted on by

Güven Barış Cansu, Bengür Taşkıran, Giampaolo Trivellin, Fabio R. Faucz, Constantine A. Stratakis

Download PDF

Familial isolated pituitary adenomas (FIPA) constitute 2-3% of pituitary tumours. AIP is the most commonly mutated gene in FIPA. We herein report a novel germline mutation of the AIP gene in a family with FIPA. We present two patients, a father and his 12-year-old daughter, diagnosed clinically and using laboratory measures with acromegaly-gigantism …

Case Report: Primary pituitary non-Hodgkin’s lymphoma developed following surgery and radiation of a pituitary macroadenoma

Posted on by

Labrini Papanastasiou, Theodora Pappa, Aikaterini Dasou, Efi Kyrodimou, George Kontogeorgos, Christianna Samara, Panagiotis Bacaracos, Athanasios Galanopoulos, George Piaditis

Download PDF

OBJECTIVE: Primary central nervous system (CNS) non-Hodgkin’s lymphoma is a rarely encountered clinical entity. Here we present a case of a primary CNS diffuse large B-cell non-Hodgkin’s lymphoma developed on a previously operated and irradiated pituitary macroadenoma. DESIGN-RESULTS: A 60-year-old woman presented with muscle weakness …

Baubo: a Case of Ambiguous Genitalia in the Eleusinian Mysteries

Posted on by

Neoklis A. Georgopoulos, George A. Vagenakis, Apostolos L. Pierris

Download PDF

In an Orphic account of the constitutive mythology of the Eleusinian Mysteries, there occurs the relation of a remarkable tale of sacred obscenity. The Baubo affair is pivotal for a more in-depth understanding of the symbolism involved in the most awesome mysteric cult of the ancient Greek world …

Adiponectin levels may help assess the clinical repercussions of obesity irrespective of body mass index

Posted on by

Eirini Dermitzaki, Pavlina D. Avgoustinaki, Eirini C. Spyridaki, Panagiotis Simos, Niki Malliaraki, Maria Venihaki, Christos Tsatsanis, Andrew N. Margioris

Download PDF

OBJECTIVE: Adiponectin is the major product of adipose tissue. The aim of this study was to associate adiponectin levels with adipose tissue and metabolic indices. DESIGN: Plasma samples of 274 non-diabetic volunteers were collected to evaluate for adiponectin, inflammatory markers, insulin and lipid parameters. Body fat composition was measured by DEXA. RESULTS: As expected, adiponectin levels correlated with body mass index (BMI) …

Which is the best predictor of thyroid cancer: thyrotropin, thyroglobulin or their ratio?

Posted on by

Pinar Yazici, Mehmet Mihmanli, Emre Bozkurt, Feyza Yener Ozturk, Mehmet Uludag

Download PDF

OBJECTIVE: Since documented incidence of thyroid cancer has been rising over time, in part due to incidental small papillary cancer, several studies have been carried out to investigate the role of possible serum markers of thyroid cancer prior to surgery. DESIGN: Prospective cohort study. AIM: To investigate the role of thyroglobulin (Tg), thyrotropin (TSH) and the TSH:Tg, Tg:TSH ratio in the preoperative diagnosis of thyroid cancer …

Sequential treatment with teriparatide and strontium ranelate in a postmenopausal woman with atypical femoral fractures after long-term bisphosphonate administration

Posted on by

Kalliopi Lampropoulou-Adamidou, Symeon Tournis, Alexia Balanika, Ioulia Antoniou, Ioannis P. Stathopoulos, Christos Baltas, Ioannis K. Triantafillopoulos, Nikolaos A. Papaioannou

Download PDF

OBJECTIVE: Despite the existence of numerous case series, no evidenced-based medical management for atypical fractures associated with bisphosphonate (BP) treatment has been established. DESIGN: We report the outcome of teriparatide (TRP) administration followed …

Diabetic retinopathy: An historical assessment

Posted on by

George Kalantzis, Michael Angelou, Effie Poulakou-Rebelakou

Download PDF

Diabetic retinopathy is a microvascular complication of diabetes mellitus and is a significant cause of new-onset blindness. Diabetic macular changes in the form of yellowish spots and full or partial thickness extravasations through the retina were observed for the first time by Eduard Jäger. In 1855, he published “Beiträge zur Pathologie des Auges” where he included his fundus paintings…

Aggressive silent corticotroph adenoma progressing to pituitary carcinoma. The role of temozolomide therapy

Posted on by

Olga Moshkin, Luis V. Syro, Bernd W. Scheithauer, Leon D. Ortiz, Camilo E. Fadul, Humberto Uribe, Ricardo Gonzalez, Michael Cusimano, Eva Horvath, Fabio Rotondo, Kalman Kovacs

Download PDF

Temozolomide (TMZ) has recently been recommended as a novel approach in the management of aggressive pituitary tumors. Herein, we present the case of a 43-year-old man with a 20-year history of silent subtype 2 pituitary corticotroph adenoma. Nine surgical resections and radiotherapy had failed to provide a cure. Morphological evaluation of the tumor revealed …

A novel mutation in the NR0B1 (DAX1) gene in a large family with two boys affected by congenital adrenal hypoplasia

Posted on by

Aleksandra Rojek, Maciej Flader, Elzbieta Malecka, Marek Niedziela

Download PDF

OBJECTIVE: X-linked Adrenal Hypoplasia Congenita (AHC) is a rare disorder caused by mutations in NR0B1 (DAX1) gene. DESIGN: We present two boys (cousins) with AHC who came to our attention at the age of 10 days and 15 days, respectively, in a life-threatening state …

The Hippocratic Spirit

Posted on by

George K. Daikos

Download PDF

The Hippocratic medical school (the medical school of Kos) was not an isolated phenomenon but the evolution and consequence of previous ideas and practices derived from many older sources. Hippocratic medicine1-3 replaced the theurgical and hieratic medicine, succeeding to and evolving from the medicine of the Minoan civilization of Crete …

A thymic carcinoid tumour causing Zollinger-Ellison and Cushing’s syndromes due to ectopic ACTH and gastrin secretion

Posted on by

Noel P. Somasundaram, Chaminda Garusinghe, Dan Berney, Ashley B. Grossman

Download PDF

Cushings’s syndrome due to ectopic adrenocorticotrophin (ACTH) secretion was first described nearly a century ago by Hurst Brown. Bronchial carcinomas, usually bronchial carcinoids, were the first to be described and continue to be the leading cause of the ectopic ACTH syndrome …

Thyroid tuberculosis

Posted on by

Konstantinos Terzidis, Panagoula Tourli, Erasmia Kiapekou, Maria Alevizaki

Download PDF

Although the association of thyroid disorders with tuberculosis has been known for a long time, the diagnosis of thyroid tuberculosis is rare. Differential diagnosis can be very difficult without fine needle aspiration. The clinical course of the disease may resemble toxic goiter or acute thyroiditis or may follow a subacute or chronic pattern without specific symptomatology…

Predictors of amputation in diabetics with foot ulcer: Single center experience in a large Turkish cohort

Posted on by

Sena Yesil, Baris Akinci, Serkan Yener, Firat Bayraktar, Ozalp Karabay, Hasan Havitcioglu, Nur Yapar, Atay Atabey5 Yasin Kucukyavas, Abdurrahman Comlekci, Sevinc Eraslan

Download PDF

OBJECTIVE: Prediction of diabetic foot ulcer outcome may be helpful for clinicians in optimizing and individualizing management strategy. The aim of the present study was to examine the possibility of predicting the outcome of patients with diabetic foot ulcers by using easily assessed clinical and laboratory parameters at baseline …