Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis

George Carayanniotis

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Increased iodide intake has been linked to the development of hypothyroidism and/or autoimmune thyroiditis in humans and animals, but the mechanisms involved remain poorly understood. Increased ingestion of iodide is likely to have pleiotropic effects on either metabolic or immunological processes. Within the latter domain, recent interest has been focused on two areas …

Iodine content of thyroglobulin in NOD.H2h4 mice developing iodine-accelerated autoimmune thyroiditis

Panayota Kolypetri, Natasha A. Noel, Karen A. Carayanniotis, George Carayanniotis

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OBJECTIVE: In NOD.H2h4 mice, high dietary iodine intake has been known to cause Iodine-accelerated Spontaneous Autoimmune Thyroiditis (ISAT) via an unknown mechanism. The aim of the study was to examine whether the NOD.h4 genetic background predisposes to enhanced iodine organification in thyroglobulin …

Thyroid tuberculosis

Konstantinos Terzidis, Panagoula Tourli, Erasmia Kiapekou, Maria Alevizaki

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Although the association of thyroid disorders with tuberculosis has been known for a long time, the diagnosis of thyroid tuberculosis is rare. Differential diagnosis can be very difficult without fine needle aspiration. The clinical course of the disease may resemble toxic goiter or acute thyroiditis or may follow a subacute or chronic pattern without specific symptomatology…