Proust-Lemoine E.1, D’ Herbomez M.2, Marchandise X.2, Wémeau J.L.1 1Clinique Endocrinologique Marc Linquette, Lille Hospital, 2Service de Medecine Nucleaire, Hopital Roger Salengro, Lille Abstract Several mechanisms, such as subacute thyroiditis, acquired organification trouble, or massive thyroid destruction, may explain precocious hypothyroidism after radioiodine treatment in Graves disease (GD) … Our purpose was to improve its Read More
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HSP90 INHIBITION AS A NOVEL THERAPEUTIC APPROACH FOR THE TREATMENT OF AGGRESSIVE THYROID CARCINOMAS
McMillin W.D.1, Kotoula V.2, Negri J.1, Hayden P.1, Koletsa T.2, Mitsiades S.C.1, Mitsiades N.1, 3 1Department of Medical Oncology, Dana Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston MA, USA, 2Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece, 3Memorial Sloan Kettering Cancer Center, New York, USA Abstract Context: Read More
Ghrelin and leptin levels in relation to puberty and reproductive function in patients with beta-thalassemia
Ghollam-Reza Moshtaghi-Kashanian, Fakhrolmulok Razavi
OBJECTIVE: Recently published animal studies indicate that leptin and ghrelin play a role in puberty initiation and progress as well as in reproduction. The aim of our study was to evaluate the relation of these two hormones to the pubertal maturity and fertility status in patients with β-thalassemia …
Peculiarities of presentation and evolution over time of Hashimoto’s thyroiditis in children and adolescents with Down’s syndrome
Tommaso Aversa, Mariacarolina Salerno, Giorgio Radetti, Maria Felicia Faienza, Lorenzo Iughetti, Andrea Corrias, Barbara Predieri, Alessandro Mussa, Silvestro Mirabelli, Filippo De Luca, Malgorzata Wasniewska
BACKGROUND: Studies concerning presentation and evolution over time of Hashimoto’s thyroiditis (HT) in children with Down’s syndrome (DS) are few, are based on limited study populations and do not include control HT groups without DS. The aim of this multicenter study was to shed further light on the relationships between DS and HT in childhood …
Stimulation of the hypothalamic-pituitary-adrenal axis with corticotropin releasing hormone in patients with psoriasis
Evangelos Karanikas, Faidon Harsoulis, Ioannis Giouzepas, Ioannis Griveas
OBJECTIVE: Psychocutaneous diseases constitute a large proportion of psychosomatic disorders, with psoriasis being one of the most typical cases. Though alteration of Hypothalamic-Pituitary-Adrenal (HPA) axis function has been suggested as underlying several psychiatric disorders and psychosomatic diseases, there is little evidence of reduced response of the HPA axis in psoriasis after psychosocially …
Modulation of monocytic lipopolysaccharide-induced tissue factor expression and tumor necrosis factor alpha release by estrogen and calcitriol
George Vlotides, Roland Gaertner, Matthias W.A. Angstwurm
OBJECTIVE: Modulatory effects of estrogens on both the immune and the coagulation system are only partially understood. In severe infections high estrogen levels have been observed both in men and postmenopausal women and are associated with increased mortality. Monocyte-derived tissue factor (TF) expression can activate the coagulation system and worsen the course of severe infection…
Stature of early Europeans
Michael Hermanussen
The ancestors of modern Europeans arrived in Europe at least 40,000 years before present. Pre-glacial maximum Upper Palaeolithic males (before 16,000 BC) were tall and slim (mean height 179 cm, estimated average body weight 67 kg), while the females were comparably small and robust (mean height 158 cm, estimated average body weight 54 kg) …
Complications and risk factors related to the extent of surgery in thyroidectomy. Results from 2,043 procedures
Stavros N. Karamanakos, Kostas B. Markou, Konstantinos Panagopoulos, Dionisios Karavias, Constantinos E. Vagianos, Chrisoula D. Scopa, Vassiliki Fotopoulou, Anna Liava, Konstantinos Vagenas
OBJECTIVE: To evaluate the rate of complications and the risk factors in relation to the extent of surgery in patients undergoing thyroidectomy in a tertiary university center. DESIGN: Data were collected retrospectively from 2,043 consecutive patients who underwent thyroid surgery for various thyroid diseases at the University Hospital of Patras …
Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values
Marianna Katrinaki, Marilena Kampa, Andrew Margioris, Elias Castanas, Niki Malliaraki
OBJECTIVE: The determination of the normal range of 25-hydroxyvitamin D [25-(OH)D], though currently based on suppression of PTH levels, still remains a controversial issue. The 25-(OH)D levels exhibit gender and seasonal variability, the latter attributed in part to changes of insolation. DESIGN: The aim of this cross-sectional study was to estimate the levels of 25-(OH)D on the island of Crete …
Low vitamin D status is associated with hypothyroid Hashimoto’s thyroiditis
Dohee Kim
OBJECTIVE: The association of low vitamin D status with autoimmune thyroid disease (AITD), which includes Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), is controversial. The aim of this study was to investigate the correlation between vitamin D insufficiency and AITD, HT, and GD. DESIGN: Our cross-sectional study included patients …
Effect of Restoration of Euthyroidism on Peripheral Blood Cells and Erythropoietin in Women with Subclinical Hypothyroidism
Mirjam Christ-Crain, Christian Meier, Peter Huber, Henryk Zulewski, Jean-Jacques Staub, Beat Müller
Background: In overt hypothyroidism (OH) anemia is common, while less frequently basophilia has been described. In subclinical hypothyroidism (SCH), however, data on the distribution of peripheral blood cells are lacking. Therefore, we evaluated the effects of L-T4 replacement therapy on peripheral blood elements in female patients with SCH before and after restoration …
Hypogonadism as a possible link between metabolic diseases and erectile dysfunction in aging men
Giovanni Corona, Silvia Bianchini, Alessandra Sforza, Linda Vignozzi, Mario Maggi
There is evidence demonstrating that sexual complaints represent the most specific symptoms associated with late onset hypogonadism, while central obesity is the most specific sign. In obese men, hypogonadism can further worsen the metabolic profile and increase abdominal fat …
Roles of Protein Kinase A (PKA) and PKC on Corticotropin-Releasing Hormone (CRH)-Induced Elevation of Cytosolic Calcium from Extra- and Intra-cellular Sources
Irini Dermitzaki, Christos Tsatsanis, Vassiliki-Ismini Alexaki, Elias Castanas, Andrew N. Margioris
Corticotropin-releasing hormone (CRH) affects cytosolic calcium ion levels. The aim of the present work was to examine the role of protein kinase A (PKA)- and PKC-dependent signalling pathways in mediating the effect of CRH on calcium ion influx (from extra-cellular sources) and calcium ion mobilization (from intra-cellular stores)…
Ghrelin and growth hormone serum levels during the clonidine test in children with short stature and variable growth hormone status
Charilaos Stylianou, Assimina Galli-Tsinopoulou, Maria G. Grammatikopoulou, George Koliakos, George Varlamis
Objective: The exact role of ghrelin in the control of growth hormone (GH) secretion has not been completely clarified as yet. The aim of the present study was 1) to investigate the effect of a substance promoting GH secretion (clonidine) on ghrelin levels in children with short stature with growth hormone deficiency (GHD) and normal growth hormone …
Laron syndrome. First report from Greece
Assimina Galli-Tsinopoulou, Sanda Nousia-Arvanitakis, Ioannis Tsinopoulos, Christos Bechlivanides, Orit Shevah, Zvi Laron
Laron-type dwarfism is an autosomal recessive disorder caused by deletions or mutations of the growth hormone receptor gene. It is characterized by high circulating levels of growth hormone (GH) and low levels of insulin-like growth factor I (IGF-I). Patients are refractory to both endogenous and exogenous GH, and present severe growth retardation and obesity …
Identification of four novel mutations in the thyroid hormone receptor-β gene in 164 Spanish and 2 Greek patients with resistance to thyroid hormone
Antonio J. Amor, Irene Halperin, Rocίo Alfayate, Victoria M. Borrás, Arancha Escribano, Cintia González, Antonio Gutirrez, Montserrat Mauri, Pilar Pérez, Antonio Picό, Irene Vourliotaki, Josep Oriola
OBJECTIVE: The aim of the study was to describe the clinical, biochemical, and genetic features of a sample of Mediterranean patients with RTH (resistance to thyroid hormone) due to mutations in TRβ (thyroid hormone receptor beta) referred to our institution during the last 15 years …
Contribution of endocrine parameters in predicting outcome of multiple trauma patients in an intensive care unit
Ioannis Ilias, Konstantinos Stamoulis, Apostolos Armaganidis, Panagiotis Lyberopoulos, Marinella Tzanela, Stylianos Orfanos, Maria Theodorakopoulou, Stylianos Tsagarakis, Ioanna Dimopoulou
OBJECTIVE: To evaluate whether tentative prognostic models for intensive care unit survival of multiple trauma patients could be improved by including endocrine parameters. DESIGN: Prospective study. Patients: Eighty-three male and 11 female multiple trauma patients…
Data on pubertal development in Greek boys. A longitudinal study
Kyratsoula Pantsiotou
OBJECTIVE: Longitudinal data on boys’ puberty evolution are not available in Greece and very few such studies have been reported world-wide. We present data from a longitudinal study on height, weight, BMI and age at the different pubertal stages in Greek boys. DESIGN: At the start of the study 204 prepubertal boys aged 8-10 years …
The interrelationship of serum 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in pregnancy at term: a meta-analysis
Peter D. Papapetrou
OBJECTIVE: To assess the relationship between circulating 25(OH)D, 1,25(OH)2D, and 24,25(OH)2D in pregnancy at term, and to test the hypothesis that serum 25(OH)D and 24,25(OH)2D are repressed by high serum 1,25(OH)2D levels …
The estrogen receptor: two or more molecules, multiple variants, diverse localizations, signaling and functions. Are we undergoing a paradigm-shift as regards their significance in breast cancer?
Marilena Kampa, Vassiliki Pelekanou, George Notas, Efstathios N. Stathopoulos, Elias Castanas
White blood cells levels and PCOS: direct and indirect relationship with obesity and insulin resistance, but not with hyperandogenemia
Olga Papalou, Sarantis Livadas, Athanasios Karachalios, Nikoleta Tolia, Panayiotis Kokkoris, Konstantinos Tripolitakis, Evanthia Diamanti-Kandarakis
Muscle strength and bone in healthy women: effect of age and gonadal status
Cristiana Cipriani, Elisabetta Romagnoli, Vincenzo Carnevale, Ida Raso, Addolorata Scarpiello, Maurizio Angelozzi, Andrea Tancredi, Stefania Russo, Federica De Lucia, Jessica Pepe, Salvatore Minisola
OBJECTIVE: The aim of this work was to examine the effects of age and menopause on muscle strength and on the muscle-bone interaction. DESIGN: One hundred ninety-four healthy women (mean age 49.8 ± 12.6 SD years) were assessed …
Plasma Interleukin-6 levels, glutathione peroxidase and isoprostane in obese women before and after weight loss. Association with cardiovascular risk factors
Maria Bougoulia, Athanassios Triantos, George Koliakos
OBJECTIVE: To evaluate the levels of Interleukin-6 (IL-6), glutathione peroxidase and isoprostane in obese women and their association with markers of cardiovascular risk factors before and after weight loss. DESIGN: 36 healthy obese women of reproductive age (group A: age (mean ±SD) 35.4 ± 9.2 years, Body Mass Index (BMI) 38.5±7 kg/m2) and 30 healthy, normal weight women …
Early microvascular and macrovascular dysfunction is not accompanied by structural arterial injury in polycystic ovary syndrome
Krystallenia Alexandraki, Athanasios D. Protogerou, Theodoros G. Papaioannou, Christina Piperi, George Mastorakos, John Lekakis, Dimitrios Panidis, Evanthia Diamanti-Kandarakis
OBJECTIVE: During the last decade cardiovascular risk factors and endothelial dysfunction have been shown to be present early in life in women with Polycystic Ovary Syndrome (PCOS). The aim of the present study was a global assessment of abnormalities in the arterial bed of young women with PCOS by non-invasive, reproducible methods…
Neuroendocrine dysfunction in patients recovering from subarachnoid hemorrhage
Vladimir Jovanovic, Sandra Pekic, Marko Stojanovic, Goran Tasic, Branko Djurovic, Ivan Soldatovic, Mirjana Doknic, Dragana Miljic, Marina Djurovic, Milica Medic-Stojanoska, Vera Popovic
OBJECTIVE: Subarachnoid hemorrhage (SAH) is a recently identified risk factor for hypopituitarism, particularly growth hormone (GH) and corticotrophins deficiencies. The aim of our study was to identify possible predictor(s) for neuroendocrine dysfunction in SAH survivors. DESIGN: Pituitary function was evaluated in 93 patients …