Intramuscular administration of ACTH1-24 vs. 24-hour blood sampling in the assessment of adrenocortical function

Salvatore Alesci, Ioannis Ilias, Emmanuil Souvatzoglou, Alan G. Harris, Philip W. Gold, Alejandro R. Ayala, George P. Chrousos

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The standard intravenous short Synacthen® test (SSST) has long been accepted as one of the most reliable diagnostic tests of adrenocortical insufficiency. Intramuscular (i.m.) administration of ACTH obviates the need of venous cannulation and can be used as an alternative to the intravenous test …