Margarita Vlassi, Maria Gazouli, George Paltoglou, Panagiotis Christopoulos, Lina Florentin, Georgia Kassi, George Mastorakos
OBJECTIVE: To investigate the association between Gestational Diabetes Mellitus (GDM) and the variants rs10830963 and rs1387153 in the MTNR1B locus in a sample of the Greek population. DESIGN: One hundred seventy-five unrelated pregnant Greek women …
Eugen Melcescu, Michael Griswold, Lianbin Xiang, Sheila Belk, Denise Montgomery, Marilyn Bray, Kevin S. Del Ben, Gabriel I. Uwaifo, Gailen D. Marshall, Christian A. Koch
OBJECTIVE: Polymorphisms (SNP) in the glucocorticoid receptor (GR) gene can alter sensitivity to glucocorticoids. Previous studies of the N363S and BclI SNP in the GR gene have shown a metabolic syndrome phenotype in mostly non-African populations. The obesity phenotype of African Americans …
Vittoria Rufini, Giorgio Treglia, Germano Perotti, Alessandro Giordano
Cristiano Roberto Grimaldi Barcellos, Michelle Patrocínio Rocha, Sylvia Asaka Yamashita Hayashida, Wagner Silva Dantas, Viviane dos Reis Vieira Yance, José Antonio Miguel Marcondes
OBJECTIVE: The aim of this study was to evaluate the influence of polycystic ovary syndrome (PCOS) and obesity on circulating markers of low-grade inflammation—tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)—in young women without major cardiovascular (CV) risk factors …
Konstantinos Makrilakis, Sofia Grammatikou, Stavros Liatis, Meropi Kontogianni, Despoina Perrea, Charilaos Dimosthenopoulos, Kalliopi-Anna Poulia, Nicholas Katsilambros
OBJECTIVE: The aim of the present study was to evaluate the effectiveness of a non-intensive, community-based, lifestyle intervention program on the prevalence of metabolic syndrome (MS), in individuals at high risk for development of type 2 diabetes …
Kleopatra Alexiadou, Alexander Kokkinos, Stavros Liatis, Despoina Perrea, Nicholas Katsilambros, Nicholas Tentolouris
OBJECTIVE. Previous data suggest that apelin and visfatin play a role in metabolism and glucose homeostasis. The aim of the present study was to determine differences in plasma apelin and visfatin concentrations between healthy subjects and patients with type 1 diabetes mellitus …
Mojca Jensterle, Nika Aleksandra Kravos, Marija Pfeifer, Tomaz Kocjan, Andrej Janez
OBJECTIVE: The long-acting glucagon-like peptide 1 receptor agonist liraglutide is linked to progressive and sustained weight loss in obese people with diabetes. However, its efficacy and safety in women with polycystic ovary syndrome (PCOS) has not yet been addressed …
Panagiota Pervanidou, Giorgos Chouliaras, Athanassios Akalestos, Despoina Bastaki, Filia Apostolakou, Ioannis Papassotiriou, George P. Chrousos
OBJECTIVE: Childhood obesity and the Metabolic Syndrome (MetS) are associated with an increased risk for early onset endothelial dysfunction and atherosclerosis. Placental growth factor (PlGF), a member of the vascular endothelial growth factor family, plays an important role in atherosclerosis by stimulating angiogenesis …
Odysseas Gregoriou,George Christodoulakos, Charalambos Siristatidis, Socrates Conidaris, Evangelia Kouskouni, George Creatsas
Objective: The purpose of this study was to examine the effects of Hormone Replacement Therapy (HRT) on plasma lipoprotein levels, bone mass and the endometrium. Methods: Thirty healthy women were enrolled in the study for climacteric symptoms and received a combination of 17β-estradiol and norethisterone acetate continuously for 2 years …
Duntas L.1, Boutsiadis A.1, Loukari E.1, Mantzou E.1, Pitsouni E.2 1Endocrine Unit, Evgenidion Hospital, University of Athens, Greece, 2Biomedical Laboratory, Evgenidion Hospital, University of Athens,Greece Abstract Objective and Aim: Selenium supplementation can decrease anti-TPO levels in patients with autoimmune thyroiditis (AIT. This study was performed to evaluate the relationship between serum selenium concentrations and the Read More
Mansour Siavash, Ammar Hassanzadeh Keshteli, Mahin Hashemipour, Masoud Amini
OBJECTIVE: Iodine Deficiency (ID) was for years considered a contributing factor for endemic goiter in Iran. The present study was conducted to assess the goiter prevalence and iodine status in schoolchildren of Isfahan 16 years after the initiation of salt iodization in Iran …
Lundh C.1, Lindencrona U.1, Himmelman J.1, Lundström A.1, Berg G.2, Forssell-Aronsson E.1 1Dept. of Radiation Physics, University of Gothenburg, Göteborg, Sweden, 2Dept. of Oncology, University of Gothenburg, Göteborg, Sweden Abstract Thyroid stunning is discussed mainly regarding thyroid carcinoma patients undergoing radioiodine treatment. Attempts have been made to identify the highest absorbed dose that does not Read More
George Koukoulis, Antonis Polymeris, Ioanna Tzavara, Dimitrios Pappas, Nicke Thalassinos
Atrial Natriuretic Peptide (ANP) is a hormone produced by cardiac atrial myocytes. Thyroid hormones may affect its release. The aim of this study was to analyze the effect of hyper and hypothyroidism on the secretion of ANP and its relationship with the changes of the renin-angiotensin-aldosterone system. Plasma ANP concentration as well as plasma renin activity (PRA) and aldosterone …
Jeong J.Y.1, Kim W.G.1, Kim T.Y.1, Kim E.Y.1, Gong G.2, Hong S.J.3, Kim T.M.4, Kim W.B.1, Shong Y.K.1 1Department of Internal Medicine, Asan Medical Center/ University of Ulsan College of Medicine, Seoul, Korea, 2Department of Pathology, Asan Medical Center University of Ulsan College of Medicine, Seoul, Korea, 3Department of Surgery, Asan Medical Center University of Read More
Fotini Psychou, Polyxeni Nicolaidou, Helen Georgouli, Maria Maniati-Christidis, Catherine Dacou-Voutetakis
We report a boy with pseudohypoparathyroidism (PHP), hypothyroidism and low growth hormone (GH) values with no response to growth hormone releasing hormone (GHRH). He presented at age 17 mo because of developmental delay. He had the typical features (short stature, obesity, round face, brachydactyly) of Albright’s hereditary osteodystrophy (AHO) …
McMillin W.D.1, Kotoula V.2, Negri J.1, Hayden P.1, Koletsa T.2, Mitsiades S.C.1, Mitsiades N.1, 3 1Department of Medical Oncology, Dana Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston MA, USA, 2Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece, 3Memorial Sloan Kettering Cancer Center, New York, USA Abstract Context: Read More
Master A.1, Piekielko-Witkowska A.1, Poplawski P.1, Lampkowska J.1, Wojcicka A.1, Brozda I.1, Tanski Z.2, Williams G.R. 3, Nauman A.1 1Medical Center of Postgraduate Education, Department of Biochemistry and Molecular Biology, Warsaw, Poland, 2Province Hospital, Department of Urology, Ostroleka, Poland, 3Molecular Endocrinology Group, Imperial College London, MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK Abstract Background Read More
Vassiliki Syriou, Anestis Moisidis, Nikolaos Tamouridis, Krystallenia I. Alexandraki, Margarita Anapliotou
We present a 73-year-old man with isolated adrenocorticotropic hormone deficiency and “flexion contractures” syndrome along with a review of the relevant literature. The patient initially presented anorexia, vomiting, arthralgias, malaise, and weight loss, which progressively deteriorated during the subsequent 6 months. He was admitted to the hospital with fever, confusion, severe cachexia, sinus tachycardia, low blood pressure …
Olga Papalou, Sarantis Livadas, Athanasios Karachalios, Nikoleta Tolia, Panayiotis Kokkoris, Konstantinos Tripolitakis, Evanthia Diamanti-Kandarakis
Castagna M. G., Cipri C., Tala H., Fioravanti C., Pasqui L., Sestini F., Brilli L. Belardini V., Ghezzi M., Pacini F. Department of Internal Medicine, Endocrinology, Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Italy Abstract Recently, two different ultrasensitive serum Tg assays with low functional sensitivity (FS) (0.11 ng/ml Tg Access Read More
Proust-Lemoine E.1, D’ Herbomez M.2, Marchandise X.2, Wémeau J.L.1 1Clinique Endocrinologique Marc Linquette, Lille Hospital, 2Service de Medecine Nucleaire, Hopital Roger Salengro, Lille Abstract Several mechanisms, such as subacute thyroiditis, acquired organification trouble, or massive thyroid destruction, may explain precocious hypothyroidism after radioiodine treatment in Graves disease (GD) … Our purpose was to improve its Read More
Leonidas H. Duntas
The introduction of synthetic levothyroxine (LT4) in the late 60’s for treatment of hypothyroidism radically changed the therapeutic approach for patients with thyroid failure, enabling a more physiologic, dose-related treatment. Subsequently, the availability of LT4 preparations at a variety of doses led to an even more precise and individualized treatment schedule. Concomitantly, the acquired knowledge that …
Alevizaki M.1, Saltiki K.2, Voidonikola P.3, Anastasiou E.2, Stamatelopulos K.3, Papamichael Ch.3 1Endocrine Unit, Evgenidion Hospital, Athens University School of Medicine, Greece, 2Dept Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, Greece., 3Vascular Laboratory, Dept of Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine Abstract Objectives: Overt hypothyroidism has been associated with arterial Read More
Michael Hermanussen
The ancestors of modern Europeans arrived in Europe at least 40,000 years before present. Pre-glacial maximum Upper Palaeolithic males (before 16,000 BC) were tall and slim (mean height 179 cm, estimated average body weight 67 kg), while the females were comparably small and robust (mean height 158 cm, estimated average body weight 54 kg) …
Bayrak E., Serter R., Donderici O. ?nternal Medicine Ankara Education and Research Hospital Ankara Turkey Abstract Introduction: Papillary tumors are the most common while medullary thyroid cancer (MTC) is the third most common of all thyroid cancers. We report a case of papillary thyroid carcinoma (PTC) in the right thyroid lobe together with coexistent MTC Read More