Increased placental growth factor (PlGF) concentrations in children and adolescents with obesity and the metabolic syndrome

Panagiota Pervanidou, Giorgos Chouliaras, Athanassios Akalestos, Despoina Bastaki, Filia Apostolakou, Ioannis Papassotiriou, George P. Chrousos

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OBJECTIVE: Childhood obesity and the Metabolic Syndrome (MetS) are associated with an increased risk for early onset endothelial dysfunction and atherosclerosis. Placental growth factor (PlGF), a member of the vascular endothelial growth factor family, plays an important role in atherosclerosis by stimulating angiogenesis …

Microvessel density and VEGF expression in pituitaries of pregnant women

Fabio Rotondo, Angelo Rotondo, Mark Jentoft, Bernd W. Scheithauer, Luis V. Syro, Jorge H. Donado, James E. Tarara, Kalman Kovacs

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OBJECTIVE: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprolactinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor …