Irene Vourliotaki, Ingrid Elizabeth Bonapart, Catherine Stamataki, Eva-Maria Tsapakis, Catherine Saridaki
Dopamine agonists are the drugs of choice in the treatment of prolactinomas, the most common type of pituitary adenomas. However, up to 25% of prolactinomas do not respond to these drugs and alternative treatments have to be considered. We describe a 37-year old female with a microprolactinoma who, although having received all available formulations of dopamine agonists …
Alevizaki M.1, Saltiki K.2, Voidonikola P.3, Anastasiou E.2, Stamatelopulos K.3, Papamichael Ch.3 1Endocrine Unit, Evgenidion Hospital, Athens University School of Medicine, Greece, 2Dept Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, Greece., 3Vascular Laboratory, Dept of Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine Abstract Objectives: Overt hypothyroidism has been associated with arterial Read More
Master A.1, Piekielko-Witkowska A.1, Poplawski P.1, Lampkowska J.1, Wojcicka A.1, Brozda I.1, Tanski Z.2, Williams G.R. 3, Nauman A.1 1Medical Center of Postgraduate Education, Department of Biochemistry and Molecular Biology, Warsaw, Poland, 2Province Hospital, Department of Urology, Ostroleka, Poland, 3Molecular Endocrinology Group, Imperial College London, MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK Abstract Background Read More
Duntas L.1, Boutsiadis A.1, Loukari E.1, Mantzou E.1, Pitsouni E.2 1Endocrine Unit, Evgenidion Hospital, University of Athens, Greece, 2Biomedical Laboratory, Evgenidion Hospital, University of Athens,Greece Abstract Objective and Aim: Selenium supplementation can decrease anti-TPO levels in patients with autoimmune thyroiditis (AIT. This study was performed to evaluate the relationship between serum selenium concentrations and the Read More
Son E.J., Kim E.K., Kwak J.Y., Hong S.W., Chang H.S. Yonsei University, College of Medicine, Seoul, Korea Abstract Objective: The purpose of this study was to assess the positive predictive value of the suspicious sonographic features of solid nodules of the thyroid. Materials and Methods: We evaluated 594 sonographically detected nodules on which the fine Read More
Lundh C.1, Lindencrona U.1, Himmelman J.1, Lundström A.1, Berg G.2, Forssell-Aronsson E.1 1Dept. of Radiation Physics, University of Gothenburg, Göteborg, Sweden, 2Dept. of Oncology, University of Gothenburg, Göteborg, Sweden Abstract Thyroid stunning is discussed mainly regarding thyroid carcinoma patients undergoing radioiodine treatment. Attempts have been made to identify the highest absorbed dose that does not Read More
Jeong J.Y.1, Kim W.G.1, Kim T.Y.1, Kim E.Y.1, Gong G.2, Hong S.J.3, Kim T.M.4, Kim W.B.1, Shong Y.K.1 1Department of Internal Medicine, Asan Medical Center/ University of Ulsan College of Medicine, Seoul, Korea, 2Department of Pathology, Asan Medical Center University of Ulsan College of Medicine, Seoul, Korea, 3Department of Surgery, Asan Medical Center University of Read More
Leonidas H. Duntas
The introduction of synthetic levothyroxine (LT4) in the late 60’s for treatment of hypothyroidism radically changed the therapeutic approach for patients with thyroid failure, enabling a more physiologic, dose-related treatment. Subsequently, the availability of LT4 preparations at a variety of doses led to an even more precise and individualized treatment schedule. Concomitantly, the acquired knowledge that …
Themistoklis Mikos, Konstantinos Pantazis, Dimitrios G. Goulis, Nikolaos Maglaveras, John N. Bontis, John Papadimas
OBJECTIVE: Data Mining is a relatively new field of Medical Informatics. The aim of this study was to compare Data Mining diagnosis with clinical diagnosis by applying a Data Miner (DM) to a clinical dataset of infertile men with azoospermia. DESIGN: One hundred and forty-seven azoospermic men were clinically classified into four groups …
Mansour Siavash, Ammar Hassanzadeh Keshteli, Mahin Hashemipour, Masoud Amini
OBJECTIVE: Iodine Deficiency (ID) was for years considered a contributing factor for endemic goiter in Iran. The present study was conducted to assess the goiter prevalence and iodine status in schoolchildren of Isfahan 16 years after the initiation of salt iodization in Iran …
Antonio J. Amor, Irene Halperin, Rocίo Alfayate, Victoria M. Borrás, Arancha Escribano, Cintia González, Antonio Gutirrez, Montserrat Mauri, Pilar Pérez, Antonio Picό, Irene Vourliotaki, Josep Oriola
OBJECTIVE: The aim of the study was to describe the clinical, biochemical, and genetic features of a sample of Mediterranean patients with RTH (resistance to thyroid hormone) due to mutations in TRβ (thyroid hormone receptor beta) referred to our institution during the last 15 years …
Tommaso Aversa, Mariacarolina Salerno, Giorgio Radetti, Maria Felicia Faienza, Lorenzo Iughetti, Andrea Corrias, Barbara Predieri, Alessandro Mussa, Silvestro Mirabelli, Filippo De Luca, Malgorzata Wasniewska
BACKGROUND: Studies concerning presentation and evolution over time of Hashimoto’s thyroiditis (HT) in children with Down’s syndrome (DS) are few, are based on limited study populations and do not include control HT groups without DS. The aim of this multicenter study was to shed further light on the relationships between DS and HT in childhood …
Djuro Macut, Ivana Božić Antić, Jelica Bjekić-Macut, Dimitrios Panidis, Konstantinos Tziomalos, Danijela Vojnović Milutinović, Olivera Stanojlović, Biljana Kastratović-Kotlica, Milan Petakov, Nataša Milić
OBJECTIVE: There is a need for a simple and accurate method for the assessment of cardiovascular risk in polycystic ovary syndrome (PCOS). Lipid accumulation product (LAP) is based on the assessment of waist circumference and serum triglycerides that yield an estimation of lipid overaccumulation. We aimed to determine whether LAP is associated with metabolic syndrome (MetS) in Caucasian women with PCOS …
Biljana Nedeljkovic Beleslin, Jasmina Ciric, Milos Zarkovic, Mirjana Stojkovic, Slavica Savic, Miroslav Knezevic, Branislav Stankovic, Bozo Trbojevic
OBJECTIVE: Glucocorticoids (GC) are the treatment of choice for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still . The aim of the present study was to analyze the efficacy and tolerability of combined parenteral GC pulse therapy followed by oral GC in the interpulse period …
Dimitrios G. Goulis, Paris Polychronou, Themistokis Mikos, Grigorios Grimbizis, Sriridon Gerou, Vassiliki Pavlidou, Athanasios Papanikolaou, Basil C. Tarlatzis, Ioannis N. Bontis, Ioannis Papadimas
Objective: Inhibin-B (Inh-B) is produced by Sertoli cells and controls Follicle Stimulating Hormone (FSH) secretion through a negative feedback mechanism. The primary aim of this study was to compare Ιnh-B with FSH as predictors of the recovery of sperm in testicular fine needle aspirate in men with azoospermia …
Mirjam Christ-Crain, Christian Meier, Peter Huber, Henryk Zulewski, Jean-Jacques Staub, Beat Müller
Background: In overt hypothyroidism (OH) anemia is common, while less frequently basophilia has been described. In subclinical hypothyroidism (SCH), however, data on the distribution of peripheral blood cells are lacking. Therefore, we evaluated the effects of L-T4 replacement therapy on peripheral blood elements in female patients with SCH before and after restoration …
Bayrak E., Serter R., Donderici O. ?nternal Medicine Ankara Education and Research Hospital Ankara Turkey Abstract Introduction: Papillary tumors are the most common while medullary thyroid cancer (MTC) is the third most common of all thyroid cancers. We report a case of papillary thyroid carcinoma (PTC) in the right thyroid lobe together with coexistent MTC Read More
Irini Dermitzaki, Christos Tsatsanis, Vassiliki-Ismini Alexaki, Elias Castanas, Andrew N. Margioris
Corticotropin-releasing hormone (CRH) affects cytosolic calcium ion levels. The aim of the present work was to examine the role of protein kinase A (PKA)- and PKC-dependent signalling pathways in mediating the effect of CRH on calcium ion influx (from extra-cellular sources) and calcium ion mobilization (from intra-cellular stores)…
Ioanna Dimopoulou, Marinella Tzanela, Dimitra Vassiliadi, Irini Mavrou, Petros Kopterides, Stylianos Orfanos, Anastasia Kotanidou, Styliani Kontogiannopoulou, Spyridon Vasdekis, Iraklis Tsangaris, Apostolos Armaganidis, Anastasios Macheras, Ioannis Ilias, Georgia Kostopanagiotou, Stylianos Tsagarakis
OBJECTIVE: Perioperative pituitary-adrenal responses after major abdominal surgery have not been well characterized. The aim of the present study was to further clarify perioperative pituitary-adrenal responses. DESIGN: Thirty-six patients (20 men), aged 68±10 years (mean±SD), undergoing major abdominal operations were studied …
Godlewska M.1, Gora M.1, 2, Krasuska W.1, Banga J.P.3, Gardas A.1 1Department of Biochemistry and Molecular Biology, Medical Centre of Postgraduate Education, Warsaw, Poland, 2Department of Genetics, Institute of Biochemistry and Biophysics PAS, Warsaw, Poland, 3Division of Gene and Cell Based Therapy, King’s College London School of Medicine, London, UK Abstract The major target autoantigen Read More
Mirmiran P. Salarkia N., Hedayati M., Azizi F. Endocrine Research Center, National Nutrition and Food Technology Research Institute, Shaheed Beheshti University and Medical Services, Tehran, Iran Abstract Objective: The purpose of this study was to evaluate the effect of 10 years iodine supplementation on the IDD impact indicators in the iodine deficient schoolchildren of villages Read More
Van der Deure W., Peeters R., Visser T. Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands Abstract As a prerequisite for intracellular processes like deiodination, sulfoconjugation or binding to the thyroid hormone (TH) receptor, TH is actively transported across the cell membrane by TH transporters. Several proteins can facilitate this transport, such Read More
Castagna M. G., Cipri C., Tala H., Fioravanti C., Pasqui L., Sestini F., Brilli L. Belardini V., Ghezzi M., Pacini F. Department of Internal Medicine, Endocrinology, Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Italy Abstract Recently, two different ultrasensitive serum Tg assays with low functional sensitivity (FS) (0.11 ng/ml Tg Access Read More
Teresa Zak, Anna Noczýnska, Renata Wasikowa, Urszula Zaleska-Dorobisz, Anna Golenko
The aim of the study was to analyze data related to chronic autoimmune thyroid disease at diagnosis and at follow-up of children and adolescents in Lower Silesia in the years 1999-2004. Age, gender, incidence of thyroid disease in the family, clinical presentation, hormonal findings, levels of thyroid antibodies, results of ultrasonography, and fine needle aspiration biopsy (FNAB) were recorded …
George Ioannidis, Melpomeni Peppa, Phivi Rontogianni, Michael Callifronas, Christos Papadimitriou, Georgia Chrysanthopoulou, Lambros Anthopoulos, Matina Kesse, Nicolaos Thalassinos
People with diabetes mellitus type 2 (DM2) have a greater risk for premature morbidity and mortality due to cardiovascular disease than the general population: cardiovascular disease accounts for 75% of deaths in this population group. We examined whether or not the association of clinical cardiovascular risk factors (RF) with both …