Journal Articles

Treatment of recurrent gastrointestinal haemorrhage in a patient with von Willebrand’s disease with administration of octreotide LAR and propranolol

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Napoleon Krikis, Konstantinos Tziomalos, Vasilios Perifanis, Sofia Vakalopoulou, Asterios Karagiannis, Vasilia Garypidou, Fedon Harsoulis

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We report a patient with von Willebrand’ s disease who had had recurrent and life-threatening bleeding from the gastrointestinal tract. Despite extensive investigation, no apparent cause of haemorrhage was identified. He was successfully treated with combined administration of octreotide LAR (long-acting release) and propranolol. This is the first report on the successful use of octreotide LAR in a patient with von Willebrand’ s disease…

Comparison of two fixed activities of radioiodine therapy (370 vs. 555 MBq) in patients with Graves’ disease

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Andrew Collier, Sujoy Ghosh, Mario Hair, Iqbal Malik, Jim McGarvie

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OBJECTIVE: Radioiodine therapy is the most commonly used therapy for patients with Graves’ disease (GD) in the United Kingdom. It is considered safe, effective and relatively inexpensive. The aim of our study was to examine the outcome of 131Iodine therapy in patients with GD when two different activities of 131Iodine were used …

First trimester maternal BMI is a positive predictor of cord blood c-peptide levels while maternal visfatin levels is a negative predictor of birth weight

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Georgios Valsamakis, Dimitrios C. Papatheodorou, Alexandra Margeli, Vassilios Bakoulas, Efthymios Kapantais, Ioannis Papassotiriou, George Creatsas, Sudhesh Kumar, George Mastorakos

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OBJECTIVE: The role of first trimester maternal body mass index (BMI) and adipocytokines in cord blood c-peptide and birth weight in pregnancy was investigated. DESIGN: Seventy non-diabetic pregnant Caucasian women were recruited …

Insulin resistance in pheochromocytoma improves more by surgical rather than by medical treatment

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Evanthia Diamanti-Kandarakis, Evangelia Zapanti, Maria-Helen Peridis, Panayiotis Ntavos, George Mastorakos

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Pheochromocytoma, a neuroendocrine tumor, is often associated with hyperglycemia. To investigate the underlying pathogenetic mechanisms, five patients (3 women and 2 men, aged 49±2.5, mean±SD) with benign adrenal pheochromocytoma were studied with an oral glucose tolerance test (OGTT) and the euglycaemic clamp technique …

TSH suppressive therapy: An overview of long-term clinical consequences

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David S. Cooper

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An overview of long-term clinical consequences of TSH suppressive therapy provides evidence that serum TSH levels should be maintained at levels <0.1 mU/l in high-risk (stage III and IV) patients, whereas lower-risk patients should be allowed to have their TSH levels rise into the normal range after residual disease has been ruled out …

Endothelial progenitor cells as a cardiometabolic risk factor marker in prediabetes

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Angeliki Angelidi, Andreas Melidonis, Ioannis Protopsaltis, Theodoros N. Sergentanis, Angelos Gritzapis, Ioannis Kornezos, Theofanis Economopoulos, George Dimitriadis, Eleni Boutati, Sotirios A. Raptis

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OBJECTIVE: Endothelial progenitor cells (EPCs) have recently been considered as a potential novel marker of vascular integrity, atherosclerosis and cardiovascular risk. This study was performed to investigate the main determinants of EPC levels in individuals with prediabetes …

Ectopic thyroid tissue in the lower neck with a coexisting normally located multinodular goiter. Brief literature review

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Eleni Kousta, Konstantinos Konstantinidis, Christina Michalakis, George E. Theodoropoulos, Michalis Vorias, Michalis Georgiou, George Sambalis

Ectopic thyroid tissue in the lower neck with a coexisting normally located multinodular goiter is a rare entity. We present a 27-year old asymptomatic woman with a recent history of a painless mass in the left side of her lower neck. Thyroid function tests were normal. An ultrasound of her neck showed a multinodular goiter and a 3.4 cm solid mass in the left lower cervical area…

Iodine content of thyroglobulin in NOD.H2h4 mice developing iodine-accelerated autoimmune thyroiditis

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Panayota Kolypetri, Natasha A. Noel, Karen A. Carayanniotis, George Carayanniotis

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OBJECTIVE: In NOD.H2h4 mice, high dietary iodine intake has been known to cause Iodine-accelerated Spontaneous Autoimmune Thyroiditis (ISAT) via an unknown mechanism. The aim of the study was to examine whether the NOD.h4 genetic background predisposes to enhanced iodine organification in thyroglobulin …

A novel succinate dehydrogenase type B mutation in an Iranian family. Its genetic and clinical evaluation

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Ali A. Ghazi, Ali Mosaddegh Khah, Fereshteh Kamani, Khandan Zare, Alireza Sadeghipour, Mehdi Hedayati, Marjan Zarif Yeganeh, Treena Cranston, Ashley Grossman

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Succinate Dehydrogenase-B (SDH-B) gene mutations constitute one of the most frequent forms of hereditary paragangliomas (PGL). Genetic study is advised in all cases for the evaluation of tumour behaviour, the selection of optimal management and the surveillance of the first degree relative …

High rates of obesity prevalence in adults living in Central Greece: Data from the ARGOS Study

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George N. Koukoulis, Christina Sakka, Fotis Katsaros, Maria Goutou, Sofia Tsirona, Efthimia Tsiapali, Aristea Piterou, Ioannis Stefanidis, Nikolaos Stathakis

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OBJECTIVE: To investigate the prevalence of obesity in adults of a large region of Central Greece. DESIGN: The target group was adults aged 18 to 79 years who were residents of the region of Thessaly for at least one year. A sample of 852 individuals stratified for sex and age were included. Each subject underwent a thorough physical examination and body mass index …

Effects of synbiotic food consumption on glycemic status and serum hs-CRP in pregnant women: a randomized controlled clinical trial

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Mohsen Taghizadeh, Zatolla Asemi

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OBJECTIVE: The aim of this study was to determine the effects of synbiotic food consumption on glycemic status and serum high sensitivity C-reactive protein (hs-CRP) levels of Iranian pregnant women. DESIGN: This randomized placebo-controlled clinical trial was performed among 52 pregnant women …

The significance of the number seven in ancient Greece and its relation to Endocrinology

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Menalaos L. Batrinos

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Many ancients held various beliefs about the supernatural virtues of certain numbers. In ancient Greece, the school of Pythagoras (590 BC) taught the doctrine of the numerical essence of natural events. In accordance with this theory, the number 7 was considered a sacred number and thus vital to human life…

Spontaneous recovery from isolated post-traumatic central hypogonadism in a woman

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Rosaria M. Ruggeri, Giovanni Smedile, Francesca Granata, Marcello Longo, Salvatore Cannaíò, Nicholas J. Sarlis, Francesco Trimarchi, Salvatore Benvenga

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OBJECTIVE. Hypopituitarism is a recognized complication of Traumatic Brain Injury (TBI). Resolution of established anterior pituitary hormones deficiency is rare. CASE REPORT. A woman was initially presented at the age of 22 years with amenorrhoea. Two years earlier she had been involved in a car accident with consequent TBI …

The combined effect of MC4R and FTO risk alleles on childhood obesity in Greece

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Natalia Lazopoulou, Eleana Gkioka, Ioanna Ntalla, Panagiota Pervanidou, Alexandra-Maria Magiakou, Eleftheria Roma-Giannikou, George P. Chrousos, Ioannis Papassotiriou, George Dedoussis, Christina Kanaka-Gantenbein

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OBJECTIVE: Single nucleotide polymorphism (SNP) risk alleles of obesogenic genes, such as the fat mass and obesity-associated protein (FTO) and the melanocortin-4 receptor (MC4R) gene, have been described in both paediatrics and adult populations …

Cancer in the thyroid is not always thyroid cancer

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Katherine E. Akester, Noel Somasundaram, Salvador Diaz-Cano, Ashley B. Grossman

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Most clinicians assume that a thyroid mass which appears to be malignant is most likely a tumour arising from thyroid cells. We present a case where the thyroid malignancy was associated with a degree of systemic clinical and biochemical disturbance which suggested alternative diagnoses, and in which fine-needle aspiration revealed that the patient had a thyroid lymphoma …

Low HDL-cholesterol among normal weight, normoglycemic offspring of individuals with type 2 diabetes mellitus

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Edavan P. Praveen, Bindu Kulshreshtha, Madan L. Khurana, Jayaprakash Sahoo, Nandita Gupta, Guresh Kumar, Ariachery C. Ammini, Rajech Knadgawat

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Objective: Offspring of type 2 diabetics have an increased risk of dyslipidemia, glucose intolerance and obesity. The aim of this study was to assess the lipid levels in the offspring of diabetics with normal glucose tolerance and normal body weight. Design: Normal weight offspring of patients with type 2 diabetes mellitus (DM) who had normal glucose tolerance …

Does metformin have a “buffer effect” on serum TSH levels in euthyroid diabetic patients?

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Silvia Santos-Palacios, Antonio Brugos-Larumbe, Francisco Guillén-Grima, Ane Garmendia-Madariaga, Juan C. Galofré

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OBJECTIVE: In the last few years a number of studies have found that metformin has a thyrotropin (TSH)-lowering effect in patients with type 2 diabetes (DM2) and that this effect disappears after discontinuation of the drug. Initial studies were carried out in hypothyroid patients on levothyroxine (LT4) treatment …

Severe resistant hypoglycemia in a patient with a pancreatic neuroendocrine tumor on sunitinib treatment

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Athanasios Fountas, Stelios Tigas, Zoe Giotaki, Dimitrios Petrakis, George Pentheroudakis, Agathocles Tsatsoulis

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OBJECTIVE: Sunitinib is a tyrosine kinase inhibitor used in the therapy of pancreatic neuroendocrine tumors (PNETs), metastatic renal cancer and gastrointestinal stromal tumors. We describe a patient with PNET who presented with severe hypoglycemia following sunitinib administration …

Autonomic nervous system and cardiovascular risk assessment during one year of growth hormone (GH) replacement therapy in adults with GH deficiency

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Mara Boschetti, Massimo Casu, Sara Moretti, Claudia Teti, Valeria Albanese, Manuela Albertelli, Giovanni Murialdo, Francesco Minuto, Diego Ferone

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OBJECTIVE: This prospective study aimed to evaluate the impact of growth hormone deficiency (GHD) on cardiac autonomic tone and on cardiovascular risk and the changes after 12 months of GH replacement therapy (GHRT). GHD is associated with increased cardiovascular morbidity and mortality …

High TSH and low T4 as prognostic markers in older patients

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Evelin Mingote, Tomás Meroño, Rocío Rujelman, Alejandra Marquez, Pia Fossati, Mirta Gurfinkiel, Marta Schnitman, Fernando Brites, Cristina Faingold, Gabriela Brenta

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OBJECTIVE: To examine the association between thyroid profile and morbidity/mortality (MM) in hospitalized older patients. DESIGN: This is a retrospective study of patients over the age of 60yr admitted to the Dr. Cesar Milstein Hospital between 2009 and 2010 and who had thyroid function tests …

Microvessel density and VEGF expression in pituitaries of pregnant women

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Fabio Rotondo, Angelo Rotondo, Mark Jentoft, Bernd W. Scheithauer, Luis V. Syro, Jorge H. Donado, James E. Tarara, Kalman Kovacs

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OBJECTIVE: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprolactinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor …

Pulmonary arterial sampling was useful for localizing ectopic ACTH production in a patient with bronchial carcinoid causing Cushing syndrome

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Ikki Sakuma, Jun Saito, Yoko Matsuzawa, Masao Omura, Seiji Matsui, Takamitsu Maehara, Naoki Hasegawa, Tetsuo Nishikawa

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OBJECTIVE: We report a 44-year old man with ectopic adrenocorticotropic hormone (ACTH) syndrome caused by bronchial carcinoid that developed Cushing syndrome. METHODS: We performed several imaging studies, including chest and abdominal CT, for exploration of nodules and selective pulmonary …

Diagnostic features and outcome of surgical therapy of acromegalic patients: Experience of the last three decades

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Elisa Sala, Emanuele Ferrante, Marco Locatelli, Paolo Rampini, Giovanna Mantovani, Claudia Giavoli, Marcello Filopanti, Elisa Verrua, Elena Malchiodi, Giorgio Carrabba, Maura Arosio, Paolo Beck-Peccoz, Anna Spada, Andrea Gerardo Lania

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OBJECTIVE: Transsphenoidal (TNS) surgery remains the primary therapeutic option for GH-secreting pituitary adenomas. The aims of this study were to verify the impact of TNS surgery on treatment of acromegaly before and after identification by a dedicated neurosurgical team and to enumerate diagnostic features …