Panayota Kolypetri, Natasha A. Noel, Karen A. Carayanniotis, George Carayanniotis
OBJECTIVE: In NOD.H2h4 mice, high dietary iodine intake has been known to cause Iodine-accelerated Spontaneous Autoimmune Thyroiditis (ISAT) via an unknown mechanism. The aim of the study was to examine whether the NOD.h4 genetic background predisposes to enhanced iodine organification in thyroglobulin …
David S. Cooper
An overview of long-term clinical consequences of TSH suppressive therapy provides evidence that serum TSH levels should be maintained at levels <0.1 mU/l in high-risk (stage III and IV) patients, whereas lower-risk patients should be allowed to have their TSH levels rise into the normal range after residual disease has been ruled out …
Rosaria M. Ruggeri, Giovanni Smedile, Francesca Granata, Marcello Longo, Salvatore Cannaíò, Nicholas J. Sarlis, Francesco Trimarchi, Salvatore Benvenga
OBJECTIVE. Hypopituitarism is a recognized complication of Traumatic Brain Injury (TBI). Resolution of established anterior pituitary hormones deficiency is rare. CASE REPORT. A woman was initially presented at the age of 22 years with amenorrhoea. Two years earlier she had been involved in a car accident with consequent TBI …
Sibel Ertek, Arrigo FG Cicero, Oya Caglar, Gurbuz Erdogan
OBJECTIVE: Zinc is essential for many biochemical processes and also for cell proliferation. Thyroid hormones influence zinc metabolism by affecting zinc absorption and excretion. Additionally, zinc deficiency affects thyroid function. The aim of the present study was to evaluate a possible association of zinc levels with thyroid volume …
Masao Jinno, Kenichi Kondou, Koji Teruya
OBJECTIVE: Insulin resistance is associated with aging and stress, both common among patients repeatedly failing to conceive with in vitro fertilization (IVF repeaters). In the present study we examined whether low-dose metformin could improve the outcome in IVF repeaters without polycystic ovary syndrome (PCOS) …
Roland Gärtner, Petra Rank, Birgit Ander
OBJECTIVE: As we previously demonstrated, the inhibitory effect of iodine on thyroid cell growth is mediated by iodolactones, especially 6-iodo-5-hydroxy-eicosatrienoic acid (δ-iodolactone). In this communication we compare the effect of iodide, molecular iodine and δ-iodolactone on growth inhibition and apoptosis on three human thyroid carcinoma cell lines …
Salvatore Maria Corsello, Rosa Maria Paragliola, Pietro Locantore, Francesca Ingraudo, Maria Pia Ricciato, Carlo Antonio Rota, Paola Senes, Alfredo Pontecorvi
Zoledronic acid is a newly FDA-approved bisphosphonate for the treatment of hypercalcemia of malignancy. Although the safety and efficacy of this drug in treating hypercalcemia associated with hyperparathyroidism have not yet been established in clinically controlled trials, its off-label use is not uncommon …
Nikiforos Ballian, Ioannis I. Androulakis, Klio Chatzistefanou, Christianna Samara, Konstantinos Tsiveriotis, Gregory A. Kaltsas
Radiation-induced optic neuropathy is a rare adverse effect of radiotherapy applied for the treatment of pituitary adenomas. We report a patient with a recurrent adrenocorticotrophin secreting pituitary adenoma who received external beam irradiation after failing surgical and medical therapy …
Eirini Bathrellou, Mary Yannakoulia, Katerina Papanikolaou, Artemios Pehlivanidis, Panagiota Pervanidou, Christina Kanaka-Gantenbein, Ioanna Tokou, John Tsiantis, George P. Chrousos, Labros S. Sidossis
OBJECTIVE: To evaluate the effectiveness of active parental involvement in a lifestyle intervention for the management of childhood obesity. DESIGN: Forty-two overweight children (32 girls and 10 boys), aged 9.2±0.2 years and with percent overweight 39.8±2.7%, were randomly allocated either to a child-and-parent group …
Georgia Kostopanagiotou, Konstantinos Kalimeris, Kalliopi Christodoulaki, Constantinos Nastos, Nikolaos Papoutsidakis, Cleanthi Dima, Charalampos Chrelias, Ageliki Pandazi, Iordanis Mourouzis, Constantinos Pantos
OBJECTIVE: To compare the effects of various anaesthetics on stress response in the presence and absence of surgical stimulation. DESIGN: Twenty-nine pigs scheduled to undergo surgical central vein catheter placement were randomly allocated to receive only sedation with ketamine-midazolam (group SHAM, n=5) or general anaesthesia …
Maria P. Yavropoulou, Kalliopi Kotsa, Anna Gotzamani Psarrakou, Αlexandra Papazisi, Τheoni Tranga, Stelios Ventis, John G. Yovos
X-linked dominant hypophosphatemic rickets (XLH) is the most prevalent genetic form of hypophosphatemic rickets. Standard treatment of XLH patients includes long-term administration of phosphate and calcitriol. Treated patients usually respond well to the conventional therapy and demonstrate amelioration of rachitic symptoms and improved growth …
Alma Prieto-Tenreiro, Patricia Diaz-Guardiola
Central Hypothyroidism (Central H) is mainly due to acquired lesions, either in the pituitary, the hypothalamus or both, and in such cases it is usually associated with deficient secretion of other pituitary hormones. Isolated central hypothyroidism (I Central H) remains a very rare disease. By the use of the serum Thyroid Stimulating Hormone …
Sripathy Gopalakrishnan, Sourav Sen, Jawahar Singh Adhikari, Pradeep Kumar Chugh, Tarun Sekhri, Sankar Rajan
OBJECTIVE: Autoimmune Thyroid Disease (AITD) results from an interaction of exogenous and endogenous factors in a genetically predisposed individual. AITD is being increasingly reported among the Indian population. Lymphocyte subsets and levels of interleukin-5 (IL- 5) were studied in the peripheral blood of patients with AITD …
László G. Józsa
Pathologies depicted in sacral works of western civilisation are widely known. However, in this regard, the very rich and important Byzantine art, and particularly sacral art, has been largely ignored. Research carried out on 500 artworks has disclosed 119 pictures revealing 36 different physiological conditions (gravidity, labour) or pathological conditions …
Shabana Valiji Bharmal, Veronica Moyes, Sahid Ahmed, Ashley Grossman
Drugs are the commonest cause of hypoglycaemia in patients without diabetes mellitus. However, in spite of this, a recent review highlighted the poor quality of evidence available supporting the association between numerous drugs and hypoglycaemia …
Theodora Pappa, Labrini Papanastasiou, Athina Markou, Ioannis Androulakis, George Kontogeorgos, Andreas Seretis, George Piaditis
Simona Grozinsky-Glasberg, Susana Fichman, Ilan Shimon
Metastatic Neuroendocrine Tumor (NET) to the pineal gland is a unique manifestation previously unreported in the literature. We describe an unusual case of metastatic bronchial NET to the pineal gland in a 71-year-old male patient. His primary NET had been resected six years previously and there was no indication of the presence of disseminated metastatic disease at that time …