Christos M. Hatzis, Christopher Papandreou, Evridiki Patelarou, Constantine I. Vardavas, Eleni Kimioni, Dimitra Sifaki-Pistolla, Anna Vergetaki, Anthony G. Kafatos
OBJECTIVE: To identify the cardiovascular disease (CVD) risk-factor status and dietary habits of the surviving elderly participants of the initial Seven Countries Study (SCS) cohort and newly recruited middle-aged men from the same villages …
Eleni P. Kotanidou, Maria G. Grammatikopoulou, Bessie E. Spiliotis, Christina Kanaka-Gantenbein, Maria Tsigga, Assimina Galli-Tsinopoulou
OBJECTIVE: While the US today has the highest rates worldwide of obesity, Europe, and particularly Southern Europe, is catching up fast. The aim of this study was to report the prevalence of obesity in Greek children, aged 1-12 years. DESIGN: A systematic review—including all studies published in English and Greek …
Grigorios Rombopoulos, Magdalini Hatzikou, Dimitra Latsou, John Yfantopoulos
OBJECTIVE: To estimate the impact of hypoglycemia on the Quality of Life (QoL) and its prevalence in patients with type 2 diabetes mellitus (T2DM) in Greece. DESIGN: A cross-sectional epidemiological study was conducted in 6631 patients with T2DM …
Massimo Rizzo, Alessandro Sindoni, Raffaele Talamo Rossi, Orsola Bonaffini, Stefania Panetta, Claudio Scisca, Giuseppe Altavilla, Lucia Denaro, Antonio Rosanò, Giovanna Saraceno, Francesco Trimarchi, Salvatore Benvenga
Vassiliki Pelekanou, George Notas, Efstathios N. Stathopoulos, Elias Castanas, Marilena Kampa
Prostate cancer is one of the most common malignancies and causes of death among men in western societies. It has thus attracted the interest of the scientific community, which has resulted in great improvements in survival rates in recent years. As early as the 1940s, Huggins and Hodges first demonstrated that prostate cancer is androgen dependent …
Dimitrios Anyfantakis, Emmanouil K. Symvoulakis, Demosthenes B. Panagiotakos, Dimitrios Tsetis, Elias Castanas, Sue Shea, Maria Venihaki, Christos Lionis
OBJECTIVE: This study aimed at exploring to what extent psychosocial factors, such as religiosity/spirituality and sense of coherence, mediate the negative effects of stress on a variety of cardiometabolic indicators, i.e., hypertension, diabetes, cardiovascular and cerebrovascular disease, and atherosclerotic bio-clinical markers …
Konstantinos A. Paschos, Efterpi Chouridou, Maria Koureta, Maria Lambropoulou, George Kolios, Ekaterini Chatzaki
The corticotropin-releasing factor (CRF) system plays a crucial regulatory role in the adaptation to exogenous and endogenous stress stimuli, as well as homeostasis. Apart from the central nervous system (CNS), the members of this neuropeptide family extend their actions in the periphery …
Dimitra Metheniti, Sophia Sakka, Maria Dracopoulou, Alexandra Margeli, Ioannis Papassotiriou, Christina Kanaka-Gantenbein, George P. Chrousos, Panagiota Pervanidou
OBJECTIVE: Hypovitaminosis D has been associated with adult as well as childhood obesity. Retinol-binding-protein-4 (RBP-4) and Neutrophil Gelatinase-associated Lipocalin (NGAL) are altered in obese individuals. The aim of this study was to examine circulating 25-(OH) Vitamin D (25-(OH) D) concentrations …
Vittoria Rufini, Giorgio Treglia, Germano Perotti, Alessandro Giordano
Ekaterini Koiou, Konstantinos Tziomalos, Ilias Katsikis, Dimitrios Delkos, Elena A. Tsourdi, Dimitrios Panidis
OBJECTIVE: Polycystic ovary syndrome (PCOS) is characterized by obesity and insulin resistance (IR), which result in elevated plasminogen activator inhibitor-1 (PAI-1) levels. We aimed to assess the changes in PAI-1 levels in PCOS during treatment with metformin and during weight loss …
Marilena Kampa, Vassiliki Pelekanou, George Notas, Efstathios N. Stathopoulos, Elias Castanas
Alexandra Bargiota, Maria Delizona, Andreas Tsitouras, Georgios N. Koukoulis
OBJECTIVE: To establish factors that affect food choices among adolescents living in rural areas and to identify their food choices. DESIGN: A random sample of adolescents living in a Greek rural area (n=382) aged 12-18 years were individually interviewed …
Stergios A. Polyzos, Jannis Kountouras, Agathocles Tsatsoulis, Efthimia Zafeiriadou, Evangelia Katsiki, Kalliopi Patsiaoura, Christos Zavos, Vasiliki V. Anastasiadou, Aristidis Slavakis
OBJECTIVE: The evaluation of serum sex steroids and sex hormone-binding globulin (SHBG) levels in postmenopausal women with nonalcoholic fatty liver disease (NAFLD) and their association to the disease severity. DESIGN: Twenty-two postmenopausal women with biopsy-proven NAFLD …
Allison Pitts, Grace Ih, Meng Wei, Deepti Dhall, Nicholas N. Nissen, Alan Waxman, Run Yu
OBJECTIVE: To examine the clinical utility of 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) for diagnosing whether an adrenal mass is malignant, in contemporary clinical practice. DESIGN: Retrospective medical record review of patients from 2 databases at a large hospital …
Silvano Bertelloni, Giampiero I. Baroncelli, Eleonora Dati, Silvia Ghione, Fulvia Baldinotti, Benedetta Toschi, Paolo Simi
BACKGROUND: Short stature represents one of the main features of children with Noonan syndrome. The reason for impaired growth remains largely unknown. OBJECTIVE: To assess GH and IGF1 secretion in children with Noonan syndrome …
Kostas I. Lampropoulos, George Samonis, Panagiotis Nomikos
OBJECTIVE: Evaluation of factors influencing the outcome of microsurgical transsphenoidal surgery in patients harbouring pituitary adenomas as well as of the efficacy and safety of this procedure. DESIGN: A total of 184 consecutive patients with pituitary adenomas …
Rita Banach, Beate Bartès, Kate Farnell, Harald Rimmele, Joan Shey, Susanne Singer, Frederik A. Verburg, Markus Luster, for the Thyroid Cancer Alliance
OBJECTIVE: To comprehensively assess the experience of a large, diverse cohort and identify potential care improvements, the Thyroid Cancer Alliance, an international patient/survivor group coalition, surveyed thyroid cancer patients/survivors worldwide …
Wei Wang, Xiaobo Yang, Jianbo Liang, Ming Liao, Haiying Zhang, Xue Qin, Linjian Mo, Wenxin Lv, Zengnan Mo
Previous studies have suggested that testosterone levels are linked to a variety of diseases, such as cardiovascular disease, type-2 diabetes, the metabolic syndrome, erectile dysfunction, depression, stroke and osteoporosis. Since cigarette smoking is a major health problem and highly prevalent among men …
Lisanne Smans, Eef Lentjes, Ad Hermus, Pierre Zelissen
OBJECTIVE: Patients with Addison’s disease require lifelong treatment with glucocorticoids. At present, no glucocorticoid replacement therapy (GRT) can exactly mimic normal physiology. As a consequence, under- and especially overtreatment can occur. Suboptimal GRT may lead to various side effects …
Maria Hassapidou, Sousana K. Papadopoulou, George Vlahavas, Efthymios Kapantais, Daphne Kaklamanou, Ioannis Pagkalos, Myrto Kaklamanou, Themistoklis Tzotzas
OBJECTIVE: To investigate the association between physical activity (PA) and sedentary lifestyle (SL) patterns with overweight (OW), obesity (OB), abdominal obesity (AO) and cardiometabolic comorbidities in Greek adults based on data from the National Epidemiological Survey for the prevalence of obesity …
Antonio Picarelli, Marco Di Tola, Fabio Tabacco, Mariacatia Marino, Raffaele Borghini, Tania D’Amico, Carla Lubrano, Patrizia Gargiulo
OBJECTIVE: The management of obesity, apart from exercise, mainly involves a calorie restriction regimen. A pharmaceutical treatment is often used to improve patient compliance and diet effectiveness, although several side-effects have previously been described …
Nikolaos D. Roupas, Irene Mamali, Spyros Maragkos, Lydia Leonidou, Anastasia K. Armeni, George K. Markantes, Athanasios Tsekouras, George C. Sakellaropoulos, Kostas B. Markou, Neoklis A. Georgopoulos
OBJECTIVE: To evaluate the effect of prolonged intensive aerobic exercise and acute energy deficit (180 km ultra-marathon race) on serum leptin, adiponectin, resistin and visfatin levels and their association and interaction with serum cortisol and insulin levels in highly trained ultra-endurance runners …
Snezana Polovina, Vera Popovic, Leonidas Duntas, Natasa Milic, Dragan Micic
OBJECTIVE: The aim of our study was to evaluate the relationship between the elevated TSH and fracture risk in postmenopausal women with subclinical hypothyroidism for evaluation of individuals with a high risk for osteoporotic fractures. DESIGN: FRAX score calculation (10-year estimated risk for bone fracture) …
Shizhang Liu, Zhi Yi, Ming Ling, Jiyuan Shi
OBJECTIVE: Osteoporosis is a serious and common health issue of considerable complexity among postmenopausal women. The osteoprotegerin gene (OPG) is considered to play an important role in the pathogenesis of osteoporosis. The objective of this study was to detect single nucleotide polymorphisms …
Atieh Amouzegar, Fereidoun Azizi
Objective: To assess variations of urinary iodine concentration (UIC) during a 4-week period among pregnant and non-pregnant women in an iodine-replete area. Design: Pregnant (in their first trimester of pregnancy) and non-pregnant women referred to two maternity hospitals in Tehran were consecutively recruited from September 2005 to March 2006 …