Shizhang Liu, Zhi Yi, Ming Ling, Jiyuan Shi
OBJECTIVE: Osteoporosis is a serious and common health issue of considerable complexity among postmenopausal women. The osteoprotegerin gene (OPG) is considered to play an important role in the pathogenesis of osteoporosis. The objective of this study was to detect single nucleotide polymorphisms …
Fabio Rotondo, Angelo Rotondo, Mark Jentoft, Bernd W. Scheithauer, Luis V. Syro, Jorge H. Donado, James E. Tarara, Kalman Kovacs
OBJECTIVE: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprolactinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor …
Ikki Sakuma, Jun Saito, Yoko Matsuzawa, Masao Omura, Seiji Matsui, Takamitsu Maehara, Naoki Hasegawa, Tetsuo Nishikawa
OBJECTIVE: We report a 44-year old man with ectopic adrenocorticotropic hormone (ACTH) syndrome caused by bronchial carcinoid that developed Cushing syndrome. METHODS: We performed several imaging studies, including chest and abdominal CT, for exploration of nodules and selective pulmonary …
Sadashiv, Sunita Tiwari, Bhola Nath Paul, Sandeep Kumar, Abhijit Chandra, S. Dhananjai, Mahendra Pal Singh Negi
OBJECTIVE: The present study evaluates adiponectin mRNA in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and also evaluates its association with metabolic risk factors in postmenopausal obese women. DESIGN: A case control study was carried out on postmenopausal women …
Eugen Melcescu, William B. Horton, Karen T. Pitman, Vani Vijayakumar, Christian A. Koch
Euthyroid Graves’ orbitopathy (GO) combined with incidental papillary thyroid microcarcinoma has rarely been reported. CASE REPORT: A 61-year-old Caucasian woman initially presented with progressive fatigue, exophthalmos, and thyroid function tests within normal limits …
Adina Ghemigian, Mircea Ghemigian, Irina Popescu, Lavinia Vija, Eugenia Petrova, Nicoleta Dumitru, Dumitru Ioachim
Primary hyperparathyroidism is a common endocrine disorder that is mostly caused by solitary tumors within the parathyroid glands. Characterized by early debut and higher frequency of multiple parathyroid masses, familial forms of primary hyperparathyroidism are caused by the already known mutations …
Goran Cvijovic, Dragan Micic, Aleksandra Kendereski, Svetlana Zoric, Mirjana Sumarac-Dumanovic, Svetislav Tatic, Aleksandar Trivic, Danica Pejkovic-Stamenkovic, Danka Jeremic
OBJECTIVE: Serum calcitonin (CT) is a sensitive but not specific marker for medullary thyroid carcinoma (MTC). There are a large number of conditions that may elevate CT levels. CASE REPORT: Herein we present the case of a 47-year old woman with Hashimoto thyroiditis …
Jong Wook Kim, Eun Sook Kim, Woojun Kim, Young Do Kim, Eun Young Mo, Sung Dae Moon, Je Ho Han
A diagnosis of central hypothyroidism (CH) can be missed easily or delayed without a high index of suspicion due to normal or slightly altered thyroid stimulating hormone (TSH) levels during the initial screening test for thyroid dysfunction …
Maria Andrikoula, Amalia Sertedaki, Sofia Andrikoula, Catherine Dacou-Voutetakis, Agathocles Tsatsoulis
PROP-1 gene mutations have been reported as a cause of combined pituitary hormone deficiency. Physical and hormonal phenotypes of affected individuals are variable. We report a 63-year-old female who presented with osteoporosis
Noel P. Somasundaram, Chaminda Garusinghe, Dan Berney, Ashley B. Grossman
Cushings’s syndrome due to ectopic adrenocorticotrophin (ACTH) secretion was first described nearly a century ago by Hurst Brown. Bronchial carcinomas, usually bronchial carcinoids, were the first to be described and continue to be the leading cause of the ectopic ACTH syndrome …
Kalliopi Lampropoulou-Adamidou, Symeon Tournis, Alexia Balanika, Ioulia Antoniou, Ioannis P. Stathopoulos, Christos Baltas, Ioannis K. Triantafillopoulos, Nikolaos A. Papaioannou
OBJECTIVE: Despite the existence of numerous case series, no evidenced-based medical management for atypical fractures associated with bisphosphonate (BP) treatment has been established. DESIGN: We report the outcome of teriparatide (TRP) administration followed …
Cristina Colom, Josep Oriola, Silvia Martínez, Francisco Blanco-Vaca, Roser Casamitjana, Rosa Corcoy
Always granting that de novo mutations are possible, family history and biological characteristics are nonetheless crucial for the diagnosis of monogenic diabetes. We report here the case of two patients with monogenic diabetes in which the initial family history misled the diagnostic work-up and did not support the diagnosis …
Mehmet Kirnap, Mustafa Calis, Cumali Gokce, Selim Kurtoglu, Mustafa Ozturk, Fahrettin Kelestimur
An 18-year-old man was admitted to the clinic complaining of deterioration in the function of his hands and feet. The clinical examination revealed that his movements were clumsy and that he had disproportionally short limbs. In addition, he also had facial abnormalities of frontal bossing …
Elisa Verrua, Giovanna Mantovani, Emanuele Ferrante, Andrea Noto, Elisa Sala, Elena Malchiodi, Gaetano Iapichino, Paolo Beck-Peccoz, Anna Spada
Most of the clinical data on the safety profile of desmopressin (DDAVP), which is an effective treatment for both polyuric conditions and bleeding disorders, originate from studies on the tailoring of drug treatment, whereas few reports exist describing severe side effects secondary to drug-drug interaction …
Claudia Battista, Raffaella Viti, Salvatore Minisola, Iacopo Chiodini, Vincenzo Frusciante, Alfredo Scillitani, Vincenzo Carnevale
OBJECTIVE: To describe the biochemical effects of an over-supplementation of vitamin D3 in two patients with primary hyperparathyroidism (PHPT). DESIGN: Two patients (A and B) with PHPT took erroneously 2,400,000U …
Damiano Gullo, Rossella Gelsomino, Ilenia Marturano, Domenico Restivo, Maria Luisa Arpi, Daniela Leonardi, Giuseppina Parrinello, Sebastiano Squatrito
Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-OH CAH) is treated with both glucocorticoids (to suppress pituitary ACTH and adrenal androgen production) and mineralocorticoids (to reduce angiotensin II concentrations) …
Massimo Salvatori, Giorgio Treglia, Germano Perotti, Luca Giovanella
Radioactive iodine (131I) is a radiopharmaceutical widely used in diagnosis and therapy of benign and malignant thyroid diseases. The possible risk of cancer induced by 131I administration is a topic widely debated in the literature …
Peter D. Papapetrou
Evidence is presented that the Roman emperor Maximinus Daia had Graves’ disease and died of severe thyrotoxicosis. The information about this emperor’s terminal illness is drawn from the writings of the 4th century writers Eusebius and Lactantius. An existing statue indicates that the emperor had bilateral Graves’ ophthalmopathy …
Emmanouela Papadaki
In a recent article, three case reports of familiar isolated primary hyperparathyroidism due to HRPT 2 mutation are presented. For the detection the authors used laboratory tests, u/s and nuclear medicine imaging techniques …
Allard Dijkhuizen, Leonie Theresia van Hulsteijn, Bert Bonsing, Eleonora P.M. Corssmit, Sharita R Ramautar, Leon P.H.J. Aarts, Jaap Vuyk
Adrenalectomy for pheochromocytoma (PCC) is generally performed after preparation with α- and β-sympathicolytic agents to blunt the effects of the elevated catecholamine output. In patients also known to have hypertrophic cardiomyopathy, this preoperative workup …
Konstantinos Ziambaras
In response to the very interesting article that was published in Hormones 2012, 11(2): 147-150 “Acute transient thyroid swelling following needle biopsy: An update”, I would like to share our experiences regarding this phenomenon …