The Pathophysiology of Miscarriage in Women with Polycystic Ovary Syndrome. Review and Proposed Hypothesis of Mechanisms Involved

Paulina A. Essah, Kai I. Cheang, John E. Nestler

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The polycystic ovary syndrome (PCOS) is characterized by chronic anovulation and hyperandrogenism, and is the most common cause of anovulatory infertility in developed countries1,2. Affected women suffer not only from infertility, but also from a high rate of early pregnancy loss, defined as miscarriage during the first trimester …

Hormonal causes of recurrent pregnancy loss (RPL)

Nicola Pluchino, Panagiotis Drakopoulos, Jean Marie Wenger, Patrick Petignat, Isabelle Streuli, Andrea Riccardo Genazzani

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Endocrine disorders play a major role in approximately 8% to 12% of recurrent pregnancy loss (RPL). Indeed, the local hormonal milieu is crucial in both embryo attachment and early pregnancy. Endocrine abnormalities, including thyroid disorders, luteal phase defects, polycystic ovary syndrome …