Eftekhar H. Al Ojaimi
Although Cushing’s syndrome has been described in association with various neuroendocrine tumors producing ectopic adrenocorticotropin (ACTH), primary ovarian carcinoma rarely causes this syndrome. We hereby report the case of a 61-year-old woman presented with abdominal distension, facial swelling and skin pigmentation …
Mehmet Uludag, Gurkan Yetkin, Bulent Citgez, Adnan Isgor, Tulay Basak
The malignancy risk is low in hot thyroid nodules verified by scintigraphy. We present a rare case of papillary carcinoma, initially treated as an autonomous hot nodule. Case report. A 36-year old male patient with a hot thyroid nodule and subclinical hyperthyroidism was treated with 10mCi 131I.
Zac C. Etheridge, Christopher Schofield, Peter J.J. Prinsloo, Nigel D.C. Sturrock
Hypocalcaemia due to hypoparathyroidism following thyroidectomy is a relatively common occurrence. Standard treatment is with oral calcium and vitamin D replacement therapy; lack of response to oral therapy is rare. Herein we describe a case of hypoparathyroidism following thyroidectomy unresponsive to oral therapy …
Basil Leoutsakos, Agnes Leoutsakos
Dragana Miljic, Predrag Miljic, Mirjana Doknic, Sandra Pekic, Marko Stojanovic, Milan Petakov, Vera Popovic
Adipsic diabetes insipidus (ADI) is a rare disorder. It can occur after transcranial surgery for craniopharyngeoma, suprasellar pituitary adenoma and anterior communicating artery aneurysm but also with head injury, toluene exposure and developmental disorders. It is often associated with significant hypothalamic dysfunction …
John Doupis, Charalambos Stavrianos, Katerina Saltiki, Emily Mantzou, Antonios Mastrokostopoulos, George Philippou, Maria Alevizaki
Albania is an in-transition country in the Balkan area and among those with the lowest per capita income in Europe. The Health System of Albania, as the Albanian society itself, is now taking its first steps in adopting the Western financial model. Globalization in modern Western society, even at the level of dietary practices …
Valeria Alcantara-Aragon, Silvia Martinez-Couselo, Diana Tundidor-Rengel, Susan M. Webb, Gemma Carreras, Juan J. Espinos, Ana Chico, Francisco Blanco-Vaca, Rosa Corcoy
Non-classical congenital adrenal hyperplasia (NCCAH) due to 21-hydroxylase deficiency is one of the most frequent autosomal recessive diseases, with an estimated prevalence of 1 in 1000. It may manifest at different stages in life. In late childhood, it may present with advanced skeletal maturation …
Sripathy Gopalakrishnan, Sourav Sen, Jawahar Singh Adhikari, Pradeep Kumar Chugh, Tarun Sekhri, Sankar Rajan
OBJECTIVE: Autoimmune Thyroid Disease (AITD) results from an interaction of exogenous and endogenous factors in a genetically predisposed individual. AITD is being increasingly reported among the Indian population. Lymphocyte subsets and levels of interleukin-5 (IL- 5) were studied in the peripheral blood of patients with AITD …
Peter D. Papapetrou
According to a previously published theory, Socrates was afflicted with temporal lobe epilepsy since his childhood. Plato, Xenophon, and Aristoxenus described Socrates as having exophthalmos, probably diplopia, and some symptoms compatible with hyperthyroidism …
Alma Prieto-Tenreiro, Patricia Diaz-Guardiola
Central Hypothyroidism (Central H) is mainly due to acquired lesions, either in the pituitary, the hypothalamus or both, and in such cases it is usually associated with deficient secretion of other pituitary hormones. Isolated central hypothyroidism (I Central H) remains a very rare disease. By the use of the serum Thyroid Stimulating Hormone …
Sorina Martin, Anca Sirbu, Minodora Betivoiu, Suzana Florea, Carmen Barbu, Simona Fica
OBJECTIVE: Thyroid hormones influence the GH/IGF1 axis, but previous studies have reported discrepant results regarding serum IGF1 levels in hyperthyroidism. We have therefore investigated, at diagnosis, the relationship between serum IGF1 levels and the main characteristics of Graves’ disease (GD) …
László G. Józsa
Pathologies depicted in sacral works of western civilisation are widely known. However, in this regard, the very rich and important Byzantine art, and particularly sacral art, has been largely ignored. Research carried out on 500 artworks has disclosed 119 pictures revealing 36 different physiological conditions (gravidity, labour) or pathological conditions …
Eva Lau, Davide Carvalho, Joana Oliveira, Susana Fernandes, Paula Freitas
Familial partial lipodystrophy is an autosomal dominant genetic disorder characterized by lipoatrophy of the extremities and gluteal region and lipohypertrophy of the face, neck and/or trunk. It is associated with insulin resistance, hypertriglyceridemia and increased risk of recurrent episodes of pancreatitis …
Andreas Kiriakopoulos, Dimitrios Papaioannou, Dimitrios Linos
Objective: Adrenal tumors present with clinical features and signs unique to their specific hormonal hypersecretion. However, there have been cases in which the clinical expression has been in conflict with the histologic features of the tumor. In this communication we report an unusual clinical presentation of an adrenal cortical tumor with histologic features …
Georgios K. Markantes, Efthimios Deligeoroglou, Anastasia K. Armeni, Vasiliki Vasileiou, Christina Damoulari, Angelina Mandrapilia, Fotini Kosmopoulou, Varvara Keramisanou, Danai Georgakopoulou, George Creatsas, Neoklis A. Georgopoulos
Diodorus Siculus (Diodoros Sikeliotes) was a Greek historian and writer who lived in the 1st century B.C. He is renowned for his universal history, “Bibliotheca Historica” (Historical Library), in which cases of sexual reassignment occurring around his time were included …
Helen Thomopoulou
Fuller Albright (F.A.) was born on January 12th 1900 in Buffalo N.Y. into a very wealty family. His father donated the Albright Memorial Library Building in Scranton Pennsylvania and the Albright Museum in Buffalo and was a benefactor to many other institutions…
Kerstin Hagemann, Maura Zanolari Calderari, Aurel Perren, Ian Cree, Primus E. Mullis, Christa E. Flück
Adrenocortical tumors are rare in children and present with variable signs depending on the type of hormone excess. We herein describe the unusual presentation of a child with adrenocortical tumor and introduce the concept of in vitro chemosensitivity testing. CASE REPORT: A 10.5-year-old girl presented with hypertrichosis/hirsutism and weight loss …
Aline Freitas-de-Melo, Juan Pablo Damián, Maria José Hötzel, Georgget Banchero, Rodolfo Ungerfeld
OBJECTIVE: In rodents, progesterone (P4) pretreatment increases anxiety and response to stressors. Social isolation is a stressor that generates physiological and behavioural stress responses in sheep. The aim of the study was to compare the stress response of anoestrous ewes previously treated or not with P4 to the social isolation test. DESIGN: Ten ewes received P4 treatment during 13 d (group P4-W) and another 10 remained untreated as controls (group Con) …
Christos S. Bartsocas
Among the several causes of short stature is pycnodysostosis, also known as “Toulouse-Lautrec’s disease”. Robert Weismann-Netter is credited with the first description of the disorder which later became known as pycnodysostosis. Only a few, however, know that pycnodysostosis was also possibly Aesop’s disease …
Konstantinos Laios, Marianna Karamanou, Zenia Saridaki, George Androutsos
The name Aretaeus of Cappadocia has been linked with diabetes more than that of any other physician of antiquity, his texts forming a sophisticated synthesis of the previous knowledge on this disease copiously supplemented by his own observations …
Amit Tirosh, Salomon M. Stemmer, Evgeny Solomonov, Eldad Elnekave, Wolfgang Saeger, Yelena Ravkin, Kobi Nir, Yeela Talmor, Ilan Shimon
Malignant insulinoma usually has a poor prognosis, as no efficient medical treatment is available. The somatostatin analogs octreotide and lanreotide have limited ability to control the hypoglycemic events. Pasireotide is a multi-receptor targeted somatostatin-analog with improved affinity for SSTR5. There is to date no reported treatment experience with this drug in such tumors …
Dimitra Zianni, Marinella Tzanela, Serafim Klimopoulos, N.C. Thalassinos
A 61-year old female presented with paroxysmal hypertension and a 4.5cm left adrenal mass on CT scan. Repeated measurements of 24-hour urinary fractionated metanephrines, total catecholamines and vanillylmandelic acid (VMA) were within normal range. A further scintigraphic study …
Vasiliki Vasileiou, Anastasia K. Armeni, Apostolos L. Pierris, Neoklis A. Georgopoulos
In the literature of the Roman Era, a case of macrosomia and genital ambiguity in a newborn is described. Textual evidence concerning this case of androgynism and its symbolism is provided in the present study. Medical interpretation of such cases covers the entire spectrum …
Afif Nakhleh, Leonard Saiegh, Maria Reut, Mohammad Sheikh Ahmad, Irit Wirsansky Pearl, Carmela Shechner
OBJECTIVE: Cushing`s disease during pregnancy is associated with an increased risk for maternal and fetal complications. In recurrent Cushing`s disease following transsphenoidal surgery, and when re-operation is not feasible, medical treatment is usually considered. Cabergoline was found to be effective in reducing hypercortisolism in Cushing’s disease …
Jean-Pierre Tricot
A brief biographical note about the most honoured living scientist in Belgium, the physician, biochemist and Nobel Prize winner Christian de Duve, his research in the field of diabetes mellitus and how his revelation led to the discovery of lysosomes and to the prestigious Nobel Prize of 1974 in Physiology and Medicine is herein presented…