Polyzois Makras, Georgios Toloumis, Dimitrios Papadogias, Gregory A. Kaltsas, Michael Besser
Cushing’s syndrome (CS) is a physically and psychologically disabling disease associated with high morbidity resulting from inappropriate elevation of circulating free cortisol levels. The main features of CS are disturbance of the normal circadian rhythm of cortisol secretion, impairment of the normal feedback of the hypothalamo-pituitary-adrenal (HPA)-axis …
Ariachery C. Ammini, Saptarshi Bhattacharya, Jaya Praksh Sahoo, Jim Philip, Nikhil Tandon, Ravinder Goswami, Viveka P. Jyotsna, Rajesh Khadgawat, Sunil Chumber, Aashu Seth, Asis K. Karak, Bhawani S. Sharma, Poodipedi Sarat Chandra, Ashish Suri, Manish S. Sharma, Shashank S. Kale, Manmohan Singh
OBJECTIVE: To analyze the therapeutic results of intervention and the factors affecting the outcome of patients with Cushing’s disease (CD) cared for at the All Indian Institute of Medical Science (AIIMS), New Delhi. DESIGN. Patients with Cushing’s disease treated at a teritiary care centre from January 2000 to December 2009 were prospectively studied …
Marco Mendola, Alessia Dolci, Lanfranco Piscopello, Giustino Tomei, Dario Bauer, Sabrina Corbetta, Bruno Ambrosi
We describe a patient affected by Cushing’s disease due to the presence of double pituitary adenomas, one located within the anterior pituitary and the other in the infundibulum associated with a remnant of Rakthe’s pouch. Cure was achieved only after the infundibulum lesion was surgically removed …
Afif Nakhleh, Leonard Saiegh, Maria Reut, Mohammad Sheikh Ahmad, Irit Wirsansky Pearl, Carmela Shechner
OBJECTIVE: Cushing`s disease during pregnancy is associated with an increased risk for maternal and fetal complications. In recurrent Cushing`s disease following transsphenoidal surgery, and when re-operation is not feasible, medical treatment is usually considered. Cabergoline was found to be effective in reducing hypercortisolism in Cushing’s disease …