Ikki Sakuma, Jun Saito, Yoko Matsuzawa, Masao Omura, Seiji Matsui, Takamitsu Maehara, Naoki Hasegawa, Tetsuo Nishikawa
OBJECTIVE: We report a 44-year old man with ectopic adrenocorticotropic hormone (ACTH) syndrome caused by bronchial carcinoid that developed Cushing syndrome. METHODS: We performed several imaging studies, including chest and abdominal CT, for exploration of nodules and selective pulmonary …
Elisa Sala, Emanuele Ferrante, Marco Locatelli, Paolo Rampini, Giovanna Mantovani, Claudia Giavoli, Marcello Filopanti, Elisa Verrua, Elena Malchiodi, Giorgio Carrabba, Maura Arosio, Paolo Beck-Peccoz, Anna Spada, Andrea Gerardo Lania
OBJECTIVE: Transsphenoidal (TNS) surgery remains the primary therapeutic option for GH-secreting pituitary adenomas. The aims of this study were to verify the impact of TNS surgery on treatment of acromegaly before and after identification by a dedicated neurosurgical team and to enumerate diagnostic features …
Françoise Paris, Nicolas Kalfa, Pascal Philibert, Claire Jeandel, Laura Gaspari, Charles Sultan
Premature pubarche (PP) in girls is considered to be a benign phenomenon and is the clinical expression of premature adrenarche. Since it does not usually increase the risk of either abnormalities in pubertal development or a reduced final adult height, a non-interventional approach …
Gonzalo Díaz-Soto, Maria J. Vaquerizo, Ciro García-Alvarez, Aurelia Villar-Bonet
A 45-year-old woman, with a history of asymmetric facial flushing, was presented to the Endocrinology Unit after pituitary macroadenoma removal. After other pathological entities had been ruled out, she was diagnosed with harlequin syndrome following a lesion of the postganglionic …
Amela Lolic, Νenad Prodanovic
Objective: A survey related to iodine deficiency in the Republic of Srpska was first conducted in 1999 and resulted in the adoption of regulations concerning the quality of salt for human consumption. In order to reassess iodine status, we conducted the Republic of Srpska Iodine Deficiency Survey in 2006 …
V. Leoutsakos
Goiter is very common in many parts of the world and was recognized long before the thyroid gland itself. Since prehistoric times, the visible outgrowths in the front of the neck have been objects of curiosity and study. Their nature, appearance, cause and treatment have long been the subject of thousands of reports …
Ahmet Anık, Gönül Çatlı, Ayhan Abacı, Handan Güleryüz, Çağdaş Güdücü, Adile Öniz, Şule Can, Bumin Dündar, Ece Böber
OBJECTIVE: Kallmann syndrome (KS) is a genetic disorder with the distinctive features of hyposmia or anosmia and hypogonadotropic hypogonadism. Though hyposmia/anosmia can be evaluated by both objective and subjective smell tests, there is no study comparing these two methods in KS …
Goran Cvijovic, Dragan Micic, Aleksandra Kendereski, Svetlana Zoric, Mirjana Sumarac-Dumanovic, Svetislav Tatic, Aleksandar Trivic, Danica Pejkovic-Stamenkovic, Danka Jeremic
OBJECTIVE: Serum calcitonin (CT) is a sensitive but not specific marker for medullary thyroid carcinoma (MTC). There are a large number of conditions that may elevate CT levels. CASE REPORT: Herein we present the case of a 47-year old woman with Hashimoto thyroiditis …
Amir H. Sam, Tricia Tan, Karim Meeran
Patients with acromegaly have characteristic clinical features caused by soft tissue overgrowth. The most common cause of acromegaly is a growth hormone-secreting adenoma of the anterior pituitary. Both somatic and metabolic features of acromegaly are due to excess growth hormone (GH) secretion and high serum concentrations …
Marina Kita, Maria Sakalidou, Athanasios Saratzis, Sarris Ioannis, Avraam Avramides
Cushing’s syndrome (CS) during pregnancy is a rare nosology with only a few cases reported in the literature. Misdiagnosis is common, as the syndrome may be easily confused with preeclampsia or gestational diabetes. CS during pregnancy is usually associated with severe maternal and fetal complications..
Athanasios Christoforidis, Eirini Kazantzidou, Ioanna Tsatra, Haido Tsantali, George Koliakos, Emmanouil Hatzipantelis, George Katzos, Miranda Athanassiou-Metaxa
OBJECTIVE: Osteopenia/osteoporosis of multi-factorial pathogenetic mechanism is reported to be a significant cause of morbidity in adult patients with β-thalassaemia major. Even in young patients, decreased Bone Mineral Density (BMD) values are a consistent finding in the literature. This study was performed in order to assess BMD …
George Kontogeorgos, Eleni Thodou
OBJECTIVE: The term “null cell” adenoma was first proposed in 1980 to designate pituitary adenomas lacking clinical, biochemical and morphological markers to disclose their cell origin. DESIGN: The aim of this study was to investigate the presence of α- and β-gonadotropin subunits in clinically nonfunctioning pituitary tumors …
Costas Koufaris, Angelos Alexandrou, Carolina Sismani, Nicos Skordis
Familial neurohypophyseal diabetes insipidus (FNDI) is a disorder characterized by excess excretion of diluted urine (polyuria) and increased uptake of fluids (polydipsia). The disorder is caused by mutations affecting the AVP-NPII gene, resulting in absent or deficient secretion of the antidiuretic hormone arginine vasopressin …
Antonis Polymeris, Peter D. Papapetrou, Fotini Papandroulaki, Stavroula Thanou
OBJECTIVE: Previous studies showed that insulin stimulated directly calcitonin (Ct) secretion in the pig thyroid, while dexamethasone stimulated the production of Ct and Ct mRNA in medullary thyroid carcinoma (MTC) cell lines. The objective of this study was to investigate if hyperinsulinemia during the oral glucose tolerance test …
Adina Ghemigian, Mircea Ghemigian, Irina Popescu, Lavinia Vija, Eugenia Petrova, Nicoleta Dumitru, Dumitru Ioachim
Primary hyperparathyroidism is a common endocrine disorder that is mostly caused by solitary tumors within the parathyroid glands. Characterized by early debut and higher frequency of multiple parathyroid masses, familial forms of primary hyperparathyroidism are caused by the already known mutations …
Elias E. Mazokopakis, Christos M. Karefilakis, Ioannis K. Starakis
Several conditions and drugs induce subclinical hypothyroidism. We report a case of asymptomatic and reversible subclinical hypothyroidism in a 48-year old woman with minor depressive disorder receiving therapy with escitalopram 20 mg daily for six months …
Laszlo G. Jozsa
Photos and/or copies of one hundred Upper Paleolithic (45,000-40,000 to 10,000 BP) statues were studied, the photos having been taken from the frontal, lateral and back view. Among the 97 female idols studied, 24 were skinny (mainly young women), 15 were of normal weight, while more than half of them (51) represented overweight or very obese females whose breasts were also extremely large …
Sadashiv, Sunita Tiwari, Bhola Nath Paul, Sandeep Kumar, Abhijit Chandra, S. Dhananjai, Mahendra Pal Singh Negi
OBJECTIVE: The present study evaluates adiponectin mRNA in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and also evaluates its association with metabolic risk factors in postmenopausal obese women. DESIGN: A case control study was carried out on postmenopausal women …
Efstathia Papageorgiou, Anastassios Philippou, Athanasios Armakolas, Panagiotis F. Christopoulos, Andreas Dimakakos, Michael Koutsilieris
OBJECTIVE: Preferential IGF-1Ec expression has been firmly associated with skeletal muscle repair mechanisms, post-infarction remodeling of the myocardium, the pathophysiology of endometriosis and prostate cancer biology. Therefore, we have studied the possible biological significance of synthetic Ec peptide, a putative cleavage product of IGF-1Ec in PC-3 cells and C2C12 myoblasts …
Mehmet Kirnap, Hulusi Atmaca, Fatih Tanriverdi, Osman Ozsoy, Kursad Unluhizarci, Fahrettin Kelestimur
OBJECTIVE: To investigate the hypothalamic-pituitary-adrenal (HPA) axis via the insulin-tolerance test (ITT), standard-dose (250 μg) ACTH test (SDT) and low-dose (1 μg) ACTH test (LDT) in patients with ankylosing spondylitis (AS). DESIGN: The study group included 13 male patients with AS who were diagnosed according to the Modified New York criteria …
Ines Zendah, Hafaoua Daghfous, Sonia Ben Mrad, Fatma Tritar
Thyroid tuberculosis is a rare disease even in countries in which tuberculosis (TB) constitutes an endemic disorder. The diagnosis is often difficult as the clinical presentation has no distinct characteristics. We report a 47-year-old woman who presented with a painful nodular swelling of the neck, confirmed by physical examination and sweating…
A. Mortoglou, H. Candiloros
In order to examine the significance of differences in the triiodothyronine/thyroxine (T3/T4) ratio in the achievement of euthyroidism and in different thyroidal diseases, we studied 1050 subjects: 233 were euthyroid (Eu), 239 hypothyroid (Hypo) with initial TSH levels >15 mU/L, 273 hypothyroid on substitution therapy with L-thyroxine alone and TSH values of 0.35-3.5 mU/L, (hypoRx), 236 hyperthyroid (hyper) and 69 …
Serkan Yener, Abdurrahman Comlekci, Baris Akinci, Pinar Akan, Tevfik Demir, Firat Bayraktar, Sena Yesil
OBJECTIVE: a)To determine serum Transforming Growth Factor-beta 1 (TGF-β1) levels in patients with type 2 diabetes who do not have diabetes related complications and in healthy controls, b) to evaluate the effects of metformin and rosiglitazone on TGF-β1 levels …
Gianluca Tamagno, Donal O’Shea
The diagnosis of insulinoma is based on universally defined clinical and laboratory parameters (Whipple triad and fasting test). Pre-operative tumor localization is the main challenge in the diagnostic management of insulinomas. The pre-operative and/or intra-operative localization …
Maria Hassapidou, Efstratia Daskalou, Fotini Tsofliou, Konstantinos Tziomalos, Anastasia Paschaleri, Ioannis Pagkalos, Themistoklis Tzotzas
OBJECTIVE: Data on obesity in preschoolers are scarce in Greece, a country particularly affected by the obesity epidemic. The present study aimed to assess overweight and obesity prevalence of preschoolers in Thessaloniki, Greece, by using three different standards for defining childhood overweight and obesity …