Congenital nephrogenic diabetes insipidus in the Corpus Hippocraticum: The first description

Gregory Tsoucalas, Marianna Karamanou

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Dear Editor, In congenital nephrogenic diabetes insipidus (cNDI), polyuria and polydipsia are present from birth, as the kidney is unable to concentrate urine despite elevated concentrations of the antidiuretic hormone arginine-vasopressin. In ancient Greek medicine, physiology was, needless, to say, an as yet fairly undeveloped specialty among medico-philosophers …