Anticancer effects of metformin on neuroendocrine tumor cells in vitro

George Vlotides, Ayse Tanyeri, Matilde Spampatti, Kathrin Zitzmann, Michael Chourdakis, Gerald Spöttl, Julian Maurer, Svenja Nölting, Burkhard Göke, Christoph J. Auernhammer

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Metformin is a widely used oral antidiabetic drug with good tolerability. Recent studies suggest that it also possesses adjuvant potent anticancer properties in a variety of tumors. Neuroendocrine tumors (NETs) of the gastro-entero-pancreatic system (GEP) comprise a heterogeneous group of tumors with increasing incidence …