Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling

Derek V. Henley, Kenneth S. Korach

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A large number of natural and synthetic chemicals have been identified that are reported to disrupt the normal functioning of the endocrine system and produce untoward effects in hormone-responsive target tissues and organs in both humans and animals. These chemicals are broadly referred to as endocrine disrupting chemicals (EDCs) and consist of numerous physically …