Vana Spoulou, Christina Kanaka-Gantenbein, Irini Bathrellou, Stefano Mora, Glyceria Mostrou, Lambros Sidossis, George Chrousos, Maria Theodoridou
OBJECTIVE: Few studies have thus far assessed body composition by dual energy X-ray absorptrometry (DXA) in children with HIV, primarily because reference data for normally growing children and adolescents are not available. Our study aimed at evaluating body composition in children with HIV and their relatiοn to serum lipids and glucose homeostasis …
Edavan P. Praveen, Bindu Kulshreshtha, Madan L. Khurana, Jayaprakash Sahoo, Nandita Gupta, Guresh Kumar, Ariachery C. Ammini, Rajech Knadgawat
Objective: Offspring of type 2 diabetics have an increased risk of dyslipidemia, glucose intolerance and obesity. The aim of this study was to assess the lipid levels in the offspring of diabetics with normal glucose tolerance and normal body weight. Design: Normal weight offspring of patients with type 2 diabetes mellitus (DM) who had normal glucose tolerance …
Maria I. Kalliora, Andriani Vazeou, Dimitrios Delis, Evangelos Bozas, Ioanna Thymelli, Christos S. Bartsocas
OBJECTIVE: The aim of the study was to investigate the seasonal variation of type 1 diabetes mellitus (T1DM) diagnosis in Greek children. DESIGN: The study group consisted of 1148 patients (604 males and 544 females) who were diagnosed with T1DM during the period 1978-2008. The mean age at diagnosis was 8.32±5.01 years …
Laszlo G. Jozsa
Photos and/or copies of one hundred Upper Paleolithic (45,000-40,000 to 10,000 BP) statues were studied, the photos having been taken from the frontal, lateral and back view. Among the 97 female idols studied, 24 were skinny (mainly young women), 15 were of normal weight, while more than half of them (51) represented overweight or very obese females whose breasts were also extremely large …
Amir H. Sam, Tricia Tan, Karim Meeran
Patients with acromegaly have characteristic clinical features caused by soft tissue overgrowth. The most common cause of acromegaly is a growth hormone-secreting adenoma of the anterior pituitary. Both somatic and metabolic features of acromegaly are due to excess growth hormone (GH) secretion and high serum concentrations …
Antonis Polymeris, Peter D. Papapetrou, Fotini Papandroulaki, Stavroula Thanou
OBJECTIVE: Previous studies showed that insulin stimulated directly calcitonin (Ct) secretion in the pig thyroid, while dexamethasone stimulated the production of Ct and Ct mRNA in medullary thyroid carcinoma (MTC) cell lines. The objective of this study was to investigate if hyperinsulinemia during the oral glucose tolerance test …
Chrisanthi Zouli, Christos Tsametis, Ioannis Papadimas, Dimitrios G. Goulis
The clinical and laboratory features as well as the diagnostic and therapeutic approach of men with XYY syndrome have not been fully described. A 41-year-old infertile man was diagnosed as having a 47,XYY karyotype and a micro-prolactinoma. His 32-year-old wife had a history of five spontaneous pregnancies, all resulting in first trimester miscarriages …
Olga Moshkin, Luis V. Syro, Bernd W. Scheithauer, Leon D. Ortiz, Camilo E. Fadul, Humberto Uribe, Ricardo Gonzalez, Michael Cusimano, Eva Horvath, Fabio Rotondo, Kalman Kovacs
Temozolomide (TMZ) has recently been recommended as a novel approach in the management of aggressive pituitary tumors. Herein, we present the case of a 43-year-old man with a 20-year history of silent subtype 2 pituitary corticotroph adenoma. Nine surgical resections and radiotherapy had failed to provide a cure. Morphological evaluation of the tumor revealed …
Stelios Tigas, Petros Papachilleos, Nikolaos Ligkros, Maria Andrikoula, Agathocles Tsatsoulis
Glucocorticoids are commonly used in the treatment of patients with thyroid disorders, in particular Graves’ ophthalmopathy. Thyrotoxic hypokalemic periodic paralysis (TPP) is an infrequent but potentially serious condition characterised by recurrent episodes of weakness associated with hypokalemia …
Andreas Kiriakopoulos, Dimitrios Papaioannou, Dimitrios Linos
Objective: Adrenal tumors present with clinical features and signs unique to their specific hormonal hypersecretion. However, there have been cases in which the clinical expression has been in conflict with the histologic features of the tumor. In this communication we report an unusual clinical presentation of an adrenal cortical tumor with histologic features …
Kerstin Hagemann, Maura Zanolari Calderari, Aurel Perren, Ian Cree, Primus E. Mullis, Christa E. Flück
Adrenocortical tumors are rare in children and present with variable signs depending on the type of hormone excess. We herein describe the unusual presentation of a child with adrenocortical tumor and introduce the concept of in vitro chemosensitivity testing. CASE REPORT: A 10.5-year-old girl presented with hypertrichosis/hirsutism and weight loss …
Ilias-Dimitrios Kafetzis, Antonis Diamantopoulos, Ioannis Christakis, Basileios Leoutsakos
Greep in 1963 as well as Pang and Epple in 1980 advanced the view that the parathyroids originally appeared 100 million years ago, in the context of the evolutionary development of amphibians. This coincided with the transition of life from the calcium-rich marine environment to the terrestrial or the aquatic environments …
Carlos del Pozo, Luis García-Pascual, Montserrat Balsells, María-José Barahona, Enrique Veloso, Clarisa González, Jordi Anglada-Barceló
Parathyroid carcinoma is an infrequent cause of primary hyperparathyroidism. Although hyperparathyroidism in multiple endocrine neoplasia 1 (MEN1) syndrome is the most common manifestation, parathyroid carcinoma is rare. We report a male patient who was diagnosed at 44 years of age with parathyroid carcinoma in the context of MEN1 syndrome coincident …