admin – Page 28 – HORMONES (Archive)

Progesterone pretreatment increases the stress response to social isolation in ewes

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Aline Freitas-de-Melo, Juan Pablo Damián, Maria José Hötzel, Georgget Banchero, Rodolfo Ungerfeld

OBJECTIVE: In rodents, progesterone (P4) pretreatment increases anxiety and response to stressors. Social isolation is a stressor that generates physiological and behavioural stress responses in sheep. The aim of the study was to compare the stress response of anoestrous ewes previously treated or not with P4 to the social isolation test. DESIGN: Ten ewes received P4 treatment during 13 d (group P4-W) and another 10 remained untreated as controls (group Con) …

Pasireotide for malignant insulinoma

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Amit Tirosh, Salomon M. Stemmer, Evgeny Solomonov, Eldad Elnekave, Wolfgang Saeger, Yelena Ravkin, Kobi Nir, Yeela Talmor, Ilan Shimon

Malignant insulinoma usually has a poor prognosis, as no efficient medical treatment is available. The somatostatin analogs octreotide and lanreotide have limited ability to control the hypoglycemic events. Pasireotide is a multi-receptor targeted somatostatin-analog with improved affinity for SSTR5. There is to date no reported treatment experience with this drug in such tumors …

Delayed diagnosis of disorder of sex development (DSD) due to P450 oxidoreductase (POR) deficiency

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Vasiliki Koika, Anastasia K. Armeni, Neoklis A. Georgopoulos

CASE PRESENTATION: A 36-year old man, operated on for cryptorchidism at the age of 8 years, was referred to the Outpatient Clinic of Reproductive Endocrinology for investigation of infertility. Clinical examination revealed ambiguous genitalia: penis 4-5 cm, testicular volume 2-3 ml, hypospadias, hypertrophic foreskin and scrotum bifida. Mild hypertension was confirmed. No skeletal malformations were detected …

Cyclopes and Giants: From Homer’s Odyssey to contemporary genetic diagnosis

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Georgios K. Markantes, Anastasia Theodoropoulou, Anastasia K. Armeni, Vasiliki Vasileiou, Constantine A. Stratakis, Neoklis A. Georgopoulos

Giant is a term used to describe a legendary humanlike being of great stature and strength. In Greek mythology, the giants Cyclopes rebelled against the Olympian Gods in a battle that ended in their final defeat, this resulting in Olympian sovereignty on earth …

Iodine-131 administration and risk of cancer: “Appearances can be deceptive”

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Massimo Salvatori, Giorgio Treglia, Germano Perotti, Luca Giovanella

Radioactive iodine (¹³¹I) is a radiopharmaceutical widely used in diagnosis and therapy of benign and malignant thyroid diseases. The possible risk of cancer induced by ¹³¹I administration is a topic widely debated in the literature …

Diagnostic value of the water deprivation test in the polyuria-polydipsia syndrome

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Penelope Trimpou, Daniel S. Olsson, Olof Ehn, Oskar Ragnarsson

OBJECTIVE: Diabetes insipidus (DI) and primary polydipsia (PP) are characterised by polyuria and polydipsia. It is crucial to differentiate between these two disorders since the treatment is different. The aim of this study was to evaluate the diagnostic value of the short and an extended variant of the water deprivation test (WDT) and of measuring urinary vasopressin (AVP) in patients with polyuria and polydipsia.
DESIGN: A retrospective, single-centre study based on WDTs performed …

X-linked adrenoleukodystrophy: are signs of hypogonadism always due to testicular failure?

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Olga Karapanou, Barbara Vlassopoulou, Marinella Tzanela, Dimitrios Papadopoulos, Panagiotis Angelidakis, Helen Michelakakis, George Ioannidis, Markos Mihalatos, Smaragda Kamakari, Stylianos Tsagarakis

We present the clinical and hormonal findings of a young male with X-linked adrenoleukodystrophy (X-ALD), with special emphasis on the biochemical and clinical pattern of hypogonadism. A patient, with primary adrenal insufficiency since the age of 5 years, developed progressive neurological symptoms at the age of 29 …

Sheehan’s syndrome in Xinjiang: Clinical characteristics and laboratory evaluation of 97 patients

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Guo-li Du, Zhong-hua Liu, Min Chen, Rui Ma, Sheng Jiang, Miriguli Shayiti, Jun Zhu, Aibibai Yusufu

OBJECTIVE: To evaluate the clinical and hormonal characteristics of patients with Sheehan’s syndrome in Xinjiang, China. METHODS: 97 cases diagnosed as Sheehan’s syndrome in our hospital from 1999 to 2013 were retrospectively reviewed …

A novel mutation of the calcium-sensing receptor gene in a Greek family from Nisyros

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Evaggelia Zapanti, Aikaterini Polonifi, Michalis Kokkinos, George Boutzios, Georgia Kassi, Narjes Nasiri Ansari, Eva Kassi, Aris Polyzos

PURPOSE: Inactivating mutations of the calcium-sensing receptor (CASR) gene cause familial hypocalciuric hypercalcaemia (FHH). Here we report three siblings with FHH caused by a novel mutation in the CASR. METHODS: The case subject was a 60-year-old patient referred because of mild hypercalcaemia …

Reversal of dilated cardiomyopathy after glucagonoma excision

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Ozan M. Demir, Stavroula A. Paschou, Huw Christopher Ellis, Michael Fitzpatrick, Andreas S Kalogeropoulos, Andrew Davies, Jeremy Thompson, Simon W. Davies, Julia Grapsa

The following case presents a new insight into the relationship of glucagonomas with dilated cardiomyopathy which endocrinologists should be aware of. A 64-year old Caucasian man, born and raised in Zimbabwe, was admitted with acute pulmonary edema …

Brain and optic chiasmal herniation following cabergoline treatment for a giant prolactinoma: wait or intervene?

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Labrini Papanastasiou, Stelios Fountoulakis, Theodora Pappa, Konstantinos Liberopoulos, Dimosthenis Malliopoulos, Athina Markou, George Piaditis

OBJECTIVE: Dopamine agonists (DA) are the treatment of choice in patients with macroprolactinomas. Brain and optic chiasm herniation are unusual complications following treatment with DA. REPORT: We present a case of a giant prolactinoma complicated by visual deterioration following cabergoline treatment …

Insights into the coexistence of two mutations in the same LHCGR gene locus causing severe Leydig cell hypoplasia

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Anastasia P. Athanasoulia, Günter K. Stalla, Matthias K. Auer

BACKGROUND: Leydig cell hypoplasia is a rare autosomal recessive condition that interferes with the normal development of male external genitalia in 46,XY individuals. It is mediated by mutations in the lutropin/choriogonadotropin receptor gene, resulting in the impairment of either the binding of hormone or signal transduction …

Adrenal malignant melanoma masquerading as a pheochromocytoma in a patient with a history of a multifocal papillary and medullary thyroid carcinoma

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Maria E. Barmpari, Christos Savvidis, Anastasia D. Dede, Haridimos Markogiannakis, Christina Dikoglou, Paraskevi Xekouki, Constantine A. Stratakis, Andreas Manouras, Sofia Malaktari-Skarantavou

Objective: Adrenal masses usually represent benign and nonfunctional adrenal adenomas; however, primary or metastatic malignancy should also be considered. Discovery of an adrenal mass needs further evaluation in order to exclude malignancy and hormonal secretion. We present a rare case of a possibly primary adrenal malignant melanoma with imaging and biochemical features of a pheochromocytoma. Case report: A 61-year-old male farmer was referred for evaluation …

Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: a randomized, placebo-controlled, double-blind, crossover pilot study

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Ioannis Kyrou, Aimilia Christou, Demosthenes Panagiotakos, Charikleia Stefanaki, Katerina Skenderi, Konstantina Katsana, Constantine Tsigos

OBJECTIVE: The Humulus lupulus L. plant (hops) is used as a herbal medicinal product for anxiety/mood disorders. Our aim was to study the effects of a hops dry extract on self-reported depression, anxiety and stress levels in young adults. DESIGN: Apparently healthy young adults from our university completed the Depression Anxiety Stress Scale-21 (DASS-21) and those reporting at least mild depression …

Hypertensive crisis during adrenalectomy in a patient with pheochromocytoma and a HOCM with SAM

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Allard Dijkhuizen, Leonie Theresia van Hulsteijn, Bert Bonsing, Eleonora P.M. Corssmit, Sharita R Ramautar, Leon P.H.J. Aarts, Jaap Vuyk

Adrenalectomy for pheochromocytoma (PCC) is generally performed after preparation with α- and β-sympathicolytic agents to blunt the effects of the elevated catecholamine output. In patients also known to have hypertrophic cardiomyopathy, this preoperative workup …

Use of the FRAX calculator with and without bone mineral density in Greek women

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Ioannis Ilias, Filio Spanoudi, Eftychia Koukkou, Stamatina C. Nikopoulou

The creators of the FRAX fracture risk calculator for countries with no national reference values (such as Greece) suggest the use of FRAX from a neighboring country. For Greeks (considered to run a high risk for osteoporotic fractures) …

Comment on A. Ghemigian, et al Familial isolated primary hyperparathyroidism due to HRPT2 mutation

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Emmanouela Papadaki

In a recent article, three case reports of familiar isolated primary hyperparathyroidism due to HRPT 2 mutation are presented. For the detection the authors used laboratory tests, u/s and nuclear medicine imaging techniques …

More on the management of lateral neck ectopic thyroid tissue

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Rafael Denadai, Luίs Ricardo Martinhão Souto

We read with interest the review article by Ibrahim and Fadeyibi and have the following comments regarding the evaluation of lesions in ectopic thyroid. Although the authors point out that fine needle aspiration cytology (FNAC) is important when malignancy is suspected …

Letter to the Editor

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Andres A. Roma

It was with great interest that we read the paper titled Adrenal cortical oncocytoma mimicking pheochromocytoma by Kiriakopoulos A. et al published in the first issue of 2011 of the Journal. A few months later, we were puzzled by a very similar case …

Parathyroid carcinoma in multiple endocrine neoplasia type 1. Case report and review of the literature

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Carlos del Pozo, Luis García-Pascual, Montserrat Balsells, María-José Barahona, Enrique Veloso, Clarisa González, Jordi Anglada-Barceló

Parathyroid carcinoma is an infrequent cause of primary hyperparathyroidism. Although hyperparathyroidism in multiple endocrine neoplasia 1 (MEN1) syndrome is the most common manifestation, parathyroid carcinoma is rare. We report a male patient who was diagnosed at 44 years of age with parathyroid carcinoma in the context of MEN1 syndrome coincident …

Prevalence and determinants of type 2 diabetes mellitus in a Greek adult population

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Sofia Tsirona, Fotis Katsaros, Alexandra Bargiota, Stergios A. Polyzos, George Arapoglou, George N. Koukoulis

The prevalence of diabetes mellitus (DM) is increasing worldwide reaching epidemic proportions. The aim of the present study was to estimate the prevalence of DM in Thessaly, a large region of Central Greece, and to extrapolate our results to the population of the entire country. A random sample of 805 adults (421 females and 384 men) living in Thessaly, aged 18-80 years, was surveyed. After completing a questionnaire about health status and a thorough physical examination …

Thyrotoxic hypokalemic periodic paralysis in a Turkish patient presenting with a U wave on ECG

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Emre Gezer, Banu Şarer Yurekli, Gokçen Unal Kocabas

Hypokalemic periodic paralysis (HPP) is a rare neuromuscular disorder caused by dysfunction of the ion channels in red muscle cells and which is characterized by painless episodes of muscle weakness generally after strenuous exertion or a high-carbohydrate meal …

45,X/46,XY mosaicism: a cause of short stature in males

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Alexandra Efthymiadou, Eunice G. Stefanou, Dionisios Chrysis

45,X/46,XY mosaicism is associated with a broad spectrum of phenotypes ranging from apparently normal male development to individuals with incomplete sexual differentiation and clinical signs of Turner syndrome in both males and females. The most common presentation among individuals …

Rosiglitazone-induced anasarca without heart failure: capillary leakage?

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Selcuk Dagdelen, Mevlut Kurt, Kadriye Aydιn, Miyase Bayraktar

Severity of thiazolidinedione (Rosiglitazone)-induced fluid retention is linked almost exclusively to cardiac decompensation. We here report a 68-year old female with type 2 diabetes mellitus, in whom a life-threatening (anasarca type) acute pulmonary edema, induced by rosiglitazone plus insulin therapy …

Ectopic Cushing’s syndrome due to CRH secreting liver metastasis in a patient with medullary thyroid carcinoma

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Alexandra Chrisoulidou, Kalliopi Pazaitou-Panayiotou, Eleni Georgiou, Maria Boudina, George Kontogeorgos, Ioannis Iakovou, Ioannis Efstratiou, Frideriki Patakiouta, Iraklis Vainas

Ectopic production of CRH by a medullary thyroid carcinoma or its metastases is a rare cause of ectopic Cushing’s syndrome (ECS). We report a 45-year old male with medullary thyroid carcinoma (MTC), who, 24 years following the initial diagnosis …