Glucocorticoid hypersensitivity – HORMONES (Archive)

Dysfunction of the Hypothalamic-Pituitary-Adrenal axis in HIV infection and disease

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Evangelia Zapanti, Konstantinos Terzidis, George Chrousos

Abnormalities of the Hypothalamic-Pituitary-Adrenal (HPA) axis have been documented in HIV patients in the early as well as late stages of the infection and range from subtle subclinical disturbances to frank adrenal insufficiency. Potential etiologies of these disorders include opportunistic infections, neoplasms …

Novel insights into the molecular mechanisms underlying generalized glucocorticoid resistance and hypersensitivity syndromes

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Nicolas C. Nicolaides, Evangelia Charmandari

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Glucocorticoids play a fundamental role in many physiologic functions and contribute substantially to the achievement of homeostasis. These pleiotropic glucocorticoid actions are mediated by a ubiquitously expressed transcription factor, the human glucocorticoid receptor (hGR), which may influence the transcription …