A novel, non-functional, COL1A1 polymorphism is not associated with lumbar disk disease in young male Greek subjects unlike that of the Sp1 site

Thalia Bei, Constantinos Tilkeridis, Stavros Garantziotis, Sosipatros A. Boikos, Konstantinos Kazakos, Constantinos Simopoulos, Constantine A. Stratakis

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OBJECTIVE: We recently reported the association of the Sp1 site polymorphism of the COL1A1 gene with lumbar disk disease (LDD). In the present study we searched for a different polymorphism of the COL1A1 gene (which is usually not in linkage disequilibrium with the Sp1 site) in subjects with LDD…