Nicholas J Sarlis, Loukas Gourgiotis
Thyroid cancer (TC) is the commonest endocrine malignancy. In the overwhelming majority of cases, thyroid carcinomas are well-differentiated malignancies that respond favorably to treatment; however, this outcome cannot be absolutely guaranteed. The absence of large prospective randomized clinical trials in TC—due to its low incidence and protracted clinical course in cases with persistent/recurrent metastatic disease—results in considerable debates regarding the optimal treatment and follow-up regimens in this malignancy…