The role of Notch and Hedgehog signaling pathways in pituitary development and pathogenesis of pituitary adenomas

Maria P. Yavropoulou, Anna Maladaki, John G. Yovos

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Pituitary adenomas are usually benign tumors that cause symptoms by compression of surrounding structures or impaired hormone secretion. Treatment, whether surgical or medical depends, on the tumor subtype and degree of compression; however, a significant proportion of patients do not achieve optimal control …

The role of notch signaling in bone development and disease

Maria P. Yavropoulou, John G. Yovos

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During the last decade a considerable amount of data have been accumulated regarding the role of intracellular signaling pathways in the pathogenesis of human diseases. One of these, Notch signaling, well known for its significance in cellular development and tissue morphogenesis, has been increasingly recognized as a crucial participant …