Biological activity of the e domain of the IGF-1Ec as addressed by synthetic peptides

George Vassilakos, Anastassios Philippou, Panagiotis Tsakiroglou, Michael Koutsilieris

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Insulin-like growth factor-1 (IGF-1) is a multipotent growth factor involved in the growth, development and regulation of homeostasis in a tissue-specific manner. Alternative splicing, multiple transcription initiation sites and different polyadelynation signals give rise to diverse mRNA isoforms …