Volume 11 (2012)

Case Report: Primary pituitary non-Hodgkin’s lymphoma developed following surgery and radiation of a pituitary macroadenoma

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Labrini Papanastasiou, Theodora Pappa, Aikaterini Dasou, Efi Kyrodimou, George Kontogeorgos, Christianna Samara, Panagiotis Bacaracos, Athanasios Galanopoulos, George Piaditis

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OBJECTIVE: Primary central nervous system (CNS) non-Hodgkin’s lymphoma is a rarely encountered clinical entity. Here we present a case of a primary CNS diffuse large B-cell non-Hodgkin’s lymphoma developed on a previously operated and irradiated pituitary macroadenoma. DESIGN-RESULTS: A 60-year-old woman presented with muscle weakness …

Non tumoral hyperserotoninaemia responsive to octreotide due to dual polymorphism in UGT1A1 and UGT1A6

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Anna Maladaki, Maria P. Yavropoulou, Kalliopi Kotsa, Theoni Tranga, Stelios Ventis, John G. Yovos

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Gilbert’s syndrome is a common inherited metabolic disorder, caused by genetic aberration in the enzyme UDP-glucuronosyl-transferase 1A1 that leads to reduced glucuronidation of bilirubin. Recent advances in molecular genetics have frequently reported the concurrence of dual genetic …

Parathyroid carcinoma as a challenging diagnosis: Report of three cases

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Alfredo Campennì, Rosaria Maddalena Ruggeri, Alessandro Sindoni, Salvatore Giovinazzo, Letterio Calbo, Antonio Ieni, Maurizio Monaco, Giovanni Tuccari, Salvatore Benvenga, Sergio Baldari

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Parathyroid carcinoma (PC) is a rare malignancy with an indolent but progressive course. This rare tumour is often difficult to diagnose preoperatively, thus limiting the efficacy of surgery. As long-term survival is largely dependent on the extent of the primary surgical resection …

Macrosomia and ambiguous genitalia: a long overdue answer to the citizens of Frusino

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Vasiliki Vasileiou, Anastasia K. Armeni, Apostolos L. Pierris, Neoklis A. Georgopoulos

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In the literature of the Roman Era, a case of macrosomia and genital ambiguity in a newborn is described. Textual evidence concerning this case of androgynism and its symbolism is provided in the present study. Medical interpretation of such cases covers the entire spectrum …

Case Report: Teriparatide treatment in a case of severe pregnancy -and lactation- associated osteoporosis

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Kalliopi Lampropoulou-Adamidou, George Trovas, Ioannis P. Stathopoulos, Nikolaos A. Papaioannou

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OBJECTIVE: Pregnancy- and lactation-associated osteoporosis (PLO) is an uncommon disease. The majority of cases are seen in the third trimester or early post-partum in primagravid women and the prominent clinical feature of PLO is severe and prolonged back pain and height loss. The prevalence and aetiology of this disorder …

Aretaeus of Cappadocia and the first description of diabetes

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Konstantinos Laios, Marianna Karamanou, Zenia Saridaki, George Androutsos

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The name Aretaeus of Cappadocia has been linked with diabetes more than that of any other physician of antiquity, his texts forming a sophisticated synthesis of the previous knowledge on this disease copiously supplemented by his own observations …

A novel finding in MNGIE (Mitochondrial Neurogastrointestinal Encephalomyopathy): hypergonadotropic hypogonadism

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İsmail Hakki Kalkan, Öykü Tayfur, Erkin Öztaş, Yavuz Beyazit, Hakan Yildiz, Bilge Tunç

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Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive multisystem disorder caused by mutations in the gene encoding thymidine phosphorylase (endothelial cell growth factor 1) (ECGF1) …

Use of the FRAX calculator with and without bone mineral density in Greek women

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Ioannis Ilias, Filio Spanoudi, Eftychia Koukkou, Stamatina C. Nikopoulou

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The creators of the FRAX fracture risk calculator for countries with no national reference values (such as Greece) suggest the use of FRAX from a neighboring country. For Greeks (considered to run a high risk for osteoporotic fractures) …

45,X/46,XY mosaicism: a cause of short stature in males

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Alexandra Efthymiadou, Eunice G. Stefanou, Dionisios Chrysis

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45,X/46,XY mosaicism is associated with a broad spectrum of phenotypes ranging from apparently normal male development to individuals with incomplete sexual differentiation and clinical signs of Turner syndrome in both males and females. The most common presentation among individuals …

More on the management of lateral neck ectopic thyroid tissue

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Rafael Denadai, Luίs Ricardo Martinhão Souto

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We read with interest the review article by Ibrahim and Fadeyibi and have the following comments regarding the evaluation of lesions in ectopic thyroid. Although the authors point out that fine needle aspiration cytology (FNAC) is important when malignancy is suspected …